Friday, December 7, 2012

S. Korea confirms first death caused by Creutzfeldt-Jakob disease ?

S. Korea confirms first death caused by Creutzfeldt-Jakob disease

Publish By David K. Barger Updated 06/12/2012 8:41 pm in Health&Lifestyle / no comments

SEOUL, Nov. 29 – The first death in South Korea caused by neurodegenerative Creutzfeldt-Jakob disease was confirmed by health authorities on Tuesday.

The Center for Disorder Control (KCDC) announced that a 54-year- old woman was diagnosed with iatrogenic Creutzfeldt-Jakob disease (iCJD) after she died in July this year.

She is believed to have been infected during her brain surgery 23 years ago when she had dead brain tissue replaced with a graft of a dura mater product named Lyodura. The victim did not show symptoms until the occurrence of paralysis in her face and toe in June last year.

The KCDC said the transplanted dura mater originated from the body of a CJD patient. The center said it will track down potential patients who received similar transplants with Lyoduras around 1987.

Some 400 cases of iCDJ have been reported in 20 countries, 200 of which were caused after dura mater transplant operations. KCDC, meanwhile, stressed that there is no correlation between this case and the Variant Creutzfeldt-Jakob disease, which is often referred to as human mad cow disease.

> S. Korea confirms first death caused by Creutzfeldt-Jakob disease



Thursday, December 8, 2011

S. Korea confirms second case of iatrogenic Creutzfeldt-Jakob disease 48-year-old man 2011/12/08 11:08 KST

Wednesday, November 30, 2011

First iCJD Death Confirmed in Korea

Development of Policy and Strategy for the Control of Creutzfeldt-Jakob Disease in Korea

Choi SI, Jeong BH, Kim YS.

Korean J Epidemiol

2005 Jun 27(1):81-89. Korean.

Total References:16 Cited Korean References:2 Times Cited:0

PURPOSE: Through the understanding of the current status of transmissible spongiform encephalopathy(TSE), this study was conducted to contribute to the development of policy and strategy for the control of TSE in Korea in order to keep Korea as a bovine spongiform encephalopathy(BSE)- and variant Creutzfeldt-Jakob disease(vCJD)-free country. BSE and vCJD cases have not been found in Korea.

During 2001-2004, the number of patients who have been diagnosed as a definite or probable CJD was 121, which are consisted of 62 male and 59 female(average age: 63 years old). The occurrence of the patients was 5-59 people per year until 2003 and has been gradually increasing due to the recent increase in the diagnostic rate rather than the increase of the incidence.

In 2004, the annual occurrence of sporadic CJD(sCJD) in Korea was 1 people per million, which is similar to the average occurrence rate of the world. Two cases of chronic wasting disease(CWD) in deer were found in Chungcheongbuk-do, one in August 2001 and one in October 2001. After that, 4 more CWD-affected deer have been reported in Kyungsangnam-do area in November 2004.

We have also examined the possibility that Korean CJD occurred as a result of dietary exposure to BSE. Fortunately, all of Korean CJD patients were not vCJD cases. However, if BSE occurs in Korea, there is a great potential for most of the Korean population to be easily infected with BSE due to their highly susceptible genotype to BSE infection as well as their traditional food habit. In 2003, the total number of people who left Korea was almost identical with the total number of people who entered Korea. However, we could not analyze the number of people who visited or stayed in the UK and Europe during 1980s~1990s, in which BSE was prevalent in Europe, because there was no statistical data available.


Ilsong Institute of Life Science, Hallym University, Anyang. Department of Microbiology, Hallym University College of Medicine, Chunchon.

J Korean Med Sci. 2010 July; 25(7): 1097–1100.

Published online 2010 June 16. doi: 10.3346/jkms.2010.25.7.1097

PMCID: PMC2890893 Familial Creutzfeldt-Jakob Disease with V180I Mutation

fCJD due to the V180I, as our patient's, is extremely rare, with all reported cases have come from Japan with one from France (11, 12), and two in the United states in a non-Asian (Geschwind et al. unpublished results) (13). To our knowledge this is the first reported case in South Korea.

Korean Med Sci. 1998 Jun;13(3):234-240. Published online 2009 June 22. Copyright © 1998 The Korean Academy of Medical Sciences

Molecular analysis of prion protein gene (PRNP) in Korean patients with Creutzfeldt-Jakob disease

B H Jeong, W K Ju, K Huh, E A Lee, I S Choi, J H Im, E K Choi and Y S Kim Institute of Environment & Life Science and Department of Microbiology, College of Medicine, Hallym University, Chunchon, Korea. This


Creutzfeldt-Jakob disease (CJD), a relatively uncommon human dementia, is caused by an unconventional slow infectious agent. Several cases of CJD, clinically or histopathologically diagnosed, have been reported in Korea. In order to confirm the diagnosis of CJD and also differential diagnosis of sporadic and familial types of CJD in Korea, we studied two patients who had symptoms of CJD. The histopathological and immunohistochemical studies showed spongiform neurodegeneration and expression of abnormal isoform of prion protein (PrPSc) in astrocytes. Thus, these two patients were diagnosed CJD. To investigate whether these patients were sporadic or familial type of CJD, the molecular analyses of the prion protein gene (PRNP) were done by restriction fragment length polymorphism (RFLP) and DNA sequencing. In the cases of a healthy Korean and two CJD patients, no point mutation was detected in the known hot spots (178, 180, 200, 210, and 232) and they exhibited wild type PRNP sequences. We concluded that both patients have a sporadic type of CJD, but not familial type.

J Korean Med Sci. 1991 Sep;6(3):273-278. Published online 2009 May 26. Copyright © 1991 The Korean Academy of Medical Sciences

A case of Creutzfeldt-Jakob disease

Jae Kwan Cha, Myung Ho Kim, Suck Jun Oh and Eun Kyung Hong Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea. Abstract

Creutzfeldt-Jakob disease (CJD) is presumably caused by a slow infectious pathogen or prion. The principal clinical features of Creutzfeldt-Jakob disease are dementia, pyramidal and extrapyramidal symptoms and signs, cerebellar dysfunction, and myoclonus. The patient rapidly deteriorates, declines to a vegetative state, becomes comatous, and is ultimately dead within several months. The authors present a case of Creutzfeldt-Jakob disease, proved by clinical findings, typical serial EEG, and pathologic features.

Keywords: Creutzfeldt-Jakob disease.

SEE OTHER iCJD cases recently ;

6 December 2012

HONG KONG CHP closely monitors a probable case of sporadic Creutzfeldt-Jakob Disease

The Centre for Health Protection (CHP) of the Department of Health today (December 6) received a report from the health authority of Macao concerning a probable case of sporadic Creutzfeldt-Jakob Disease (CJD) affecting a 51-year-old female Macao resident who had undergone a brain operation in a private hospital in Hong Kong.

According to the health authority of Macao, the woman who developed progressive dementia with limbs spasm, unstable gait, muscle twitching and visual disturbance suggestive of CJD, has been admitted to a hospital in Macao on October 30. Her clinical diagnosis was sporadic CJD and the patient is now in severe condition.

Investigation by the Macao health authority revealed that the woman had received a brain surgery in a private hospital in Hong Kong on September 19.

Upon receipt of the report, the CHP acted in accordance with the international practice and advised the hospital to contact the patients who had undergone procedures using the same set of instruments as the patient since September 19.

According to the current understanding, the transmission risk is extremely low. The contact tracing is a precautionary measure.

A CHP spokesman said, "CJD is a rare disease that affects the brain and is thought to be caused by the build-up of an abnormal, transmissible protein called 'prion' in the brain."

The spokesman said surgical instruments used on the patient should have been sterilised but may not be enough to eradicate the prions which are the causing agents of the disease. Contact tracing conducted by the hospital is under way.

The clinical feature of CJD is characterised by dementia and difficulties in walking. Early symptoms include memory loss, unsteady gait and loss of co-ordination of limbs. These dementia-like symptoms will worsen and twitching of limbs and trunk will occur. Besides, visual disturbance, abnormal behaviour and seizures can occur. Most patients die within one to two years after onset of symptoms.

Since CJD is not transmitted through casual contact, isolation of patients is not necessary. To prevent the disease from spreading, tissue or organ transplant from any CJD patients or re-use of potentially contaminated surgical instruments should be avoided.

Ends/Thursday, December 6, 2012

Scientific Committee on Emerging and Zoonotic Diseases

Epidemiology of Creutzfeldt-Jakob Disease in Hong Kong

Tuesday, July 31, 2012

11 patients may have been exposed to fatal disease Creutzfeldt-Jakob Disease CJD Greenville Memorial Hospital

Thursday, August 02, 2012

CJD case in Saint John prompts letter to patients Canada

CJD case in Saint John prompts letter to patients

Friday, August 24, 2012

Iatrogenic prion diseases in humans: an update

Friday, November 23, 2012

sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA, AND CANADA

Sunday, December 2, 2012

CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE BLEW IT’

Thursday, December 06, 2012

Hong Kong CHP closely monitors a probable case of sporadic Creutzfeldt-Jakob Disease

Sunday, June 17, 2012

MBC’s PD Notebook infamous mad cow program victorious in final lawsuits South Korea

Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted USA Beef

By Terry S. Singeltary Sr.

May 15, 2008

Straight to the Source

Tuesday, May 13, 2008

Concerned Americans against Mad Cow Disease STATEMENT OF SOLIDARITY with Koreans May 13, 2008

Wednesday, February 10, 2010

The Honorable Ms. Kim Min-sun Anti-US Beef Actress Prevails in Court

Saturday, April 10, 2010


Tuesday, November 08, 2011

Can Mortality Data Provide Reliable Indicators for Creutzfeldt-Jakob Disease Surveillance? A Study in France from 2000 to 2008

Vol. 37, No. 3-4, 2011 Original Paper Conclusions:These findings raise doubt about the possibility of a reliable CJD surveillance only based on mortality data.

Terry S. Singeltary Sr. on the Creutzfeldt-Jakob Disease Public Health Crisis

full text with source references ;

Friday, November 23, 2012

sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA, AND CANADA


Saturday, October 6, 2012


Tuesday, November 6, 2012

Transmission of New Bovine Prion to Mice, Atypical Scrapie, BSE, and Sporadic CJD, November-December 2012 update

Sunday, December 2, 2012

CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE BLEW IT’