USDA VS KOREA typical or atypical BSe

South Korea Lifts Canadian Beef Ban

2012-01-20T19:44:00.000-08:00

South Korea Lifts Canadian Beef Ban

First Posted: 1/20/12 01:17 PM ET Updated: 1/20/12 10:06 PM ET

South Korea's markets are once again open to Canadian beef imports after an eight-year ban, Agriculture Minister Gerry Ritz announced Friday.

Ritz and International Trade Minister Ed Fast said the government, working closely with the beef industry, finally convinced South Korea that Canadian beef is safe.

"Ultimately we were able to overcome the last few science-based issues. We were able to satisfy them that in fact Canadian beef is in fact safe, it is the highest quality beef in the world, and the Korean market should be open to it," said Fast.

He and Ritz made the announcement at a farm in Spruce Grove, Alta., and described the reopening of South Korea's market as a "significant breakthrough" and "a big step forward."

South Korea stopped buying Canadian beef after bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, hit in Canada in 2003.

Effective immediately, South Korea will allow Canadian beef under 30 months to be imported.

"We appreciate South Korea taking this important step," said Ritz.

The ministers and their departments had tried for years to impress upon the Koreans that there was no scientific basis for the ban on beef and when that failed, they turned to the World Trade Organization to review the trade restriction.

Last June, Ottawa and Seoul agreed on a process to restore access by the end of 2011, prompting Canada to formally request a suspension of the WTO proceedings.

But Fast said despite that progress, full access to the market was far from certain and he urged his Korean counterpart at a meeting in December to reach a negotiated settlement and to recognize "the scientific facts that confirm the high quality and safe nature of Canadian beef."

"The Korean government heard our message and their decision to restore access is the direct result of our government's actions," he said.

South Korea was the last major Asian market to maintain the ban on Canadian beef.

Canada Beef Inc., the marketing division of the Canadian Cattlemen's Association, had said reopening the market could be worth $30 million to Canadian producers by 2015.

Travis Toews from the Canadian Cattlemen's Association thanked the government for its work on the file.

Toews said his industry was "decimated" by the BSE episode and that the lack of trade in one of Asia's key markets is one reason why the size of Canada's cattle herd has shrunk since 2003.

Reopening South Korea's market to beef under 30 months is a step towards finally closing the book on BSE, but the battle for full access to all beef products isn't over yet, said Toews.

"We haven't experienced closure yet. There's still a number of key markets where we need expanded access in order to return to pre-2003 market access levels," he said, noting full access to Korea hasn't been gained, and there are still barriers in other markets such as Japan and Mexico.

Toews said he is confident Canada can regain its share of the market.

http://www.huffingtonpost.ca/2012/01/20/south-korea-canada-beef-ban_n_1219470.html

that's all it has ever been about is trade. human and animal health does not matter. with c-BSE, h-BSE, and l-BSE all in North America, probably more strains along with that. i see most of the media outlets are still using outdated science. science now shows that atypical BSE and atypical scrapie (both of which are in North America), are now linked to some cases of sporadic CJD. but, the officials will not tell that to the media, and the media does not print it. and CWD, scientist are very concerned about the zoonotic potential of CWD in deer and elk. but they don't advertise that much either. oh, that's right, Canada already imported mad deer disease to South Korea.

http://www.cfsph.iastate.edu/Factsheets/pdfs/chronic_wasting_disease.pdf

the USDA, MAFF, CFIA, and the OIE are responsible for this mess, and they are only digging the graves deeper.

stupid is, as stupid does, and some times you can't fix stupid $$$

EFSA Journal 2011 The European Response to BSE: A Success Story

This is an interesting editorial about the Mad Cow Disease debacle, and it's ramifications that will continue to play out for decades to come ;

Monday, October 10, 2011

EFSA Journal 2011 The European Response to BSE: A Success Story

snip...

EFSA and the European Centre for Disease Prevention and Control (ECDC) recently delivered a scientific opinion on any possible epidemiological or molecular association between TSEs in animals and humans (EFSA Panel on Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical BSE prions as the only TSE agents demonstrated to be zoonotic so far but the possibility that a small proportion of human cases so far classified as "sporadic" CJD are of zoonotic origin could not be excluded. Moreover, transmission experiments to non-human primates suggest that some TSE agents in addition to Classical BSE prions in cattle (namely L-type Atypical BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic wasting disease (CWD) agents) might have zoonotic potential.

snip...

http://www.efsa.europa.eu/en/efsajournal/pub/e991.htm?emt=1

http://www.efsa.europa.eu/en/efsajournal/doc/e991.pdf

see follow-up here about North America BSE Mad Cow TSE prion risk factors, and the ever emerging strains of Transmissible Spongiform Encephalopathy in many species here in the USA, including humans ;

http://transmissiblespongiformencephalopathy.blogspot.com/2011/10/efsa-journal-2011-european-response-to.html

Thursday, August 12, 2010

Seven main threats for the future linked to prions

First threat

The TSE road map defining the evolution of European policy for protection against prion diseases is based on a certain numbers of hypotheses some of which may turn out to be erroneous. In particular, a form of BSE (called atypical Bovine Spongiform Encephalopathy), recently identified by systematic testing in aged cattle without clinical signs, may be the origin of classical BSE and thus potentially constitute a reservoir, which may be impossible to eradicate if a sporadic origin is confirmed.

***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.

Second threat

snip...

http://www.neuroprion.org/en/np-neuroprion.html

Friday, December 30, 2011; ;

Feds back Quebec R+D for SRM removal equipment Canada

http://transmissiblespongiformencephalopathy.blogspot.com/2011/12/feds-back-quebec-rd-for-srm-removal.html

Friday, January 6, 2012

OIE 2012 Training Manual on Wildlife Diseases and Surveillance and TSE Prion disease

http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/oie-2012-training-manual-on-wildlife.html

Monday, January 2, 2012

EFSA Minutes of the 6th Meeting of the EFSA Scientific Network on BSE-TSE Brussels, 29-30 November 2011

http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/efsa-minutes-of-6th-meeting-of-efsa.html

Friday, March 4, 2011

Alberta dairy cow found with mad cow disease

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/alberta-dairy-cow-found-with-mad-cow.html

Wednesday, August 11, 2010

REPORT ON THE INVESTIGATION OF THE SIXTEENTH CASE OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN CANADA

http://bse-atypical.blogspot.com/2010/08/report-on-investigation-of-sixteenth.html

Thursday, August 19, 2010

REPORT ON THE INVESTIGATION OF THE SEVENTEENTH CASE OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN CANADA

http://bseusa.blogspot.com/2010/08/report-on-investigation-of-seventeenth.html

Thursday, February 10, 2011

TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY REPORT UPDATE CANADA FEBRUARY 2011 and how to hide mad cow disease in Canada Current as of: 2011-01-31

http://madcowtesting.blogspot.com/2011/02/transmissible-spongiform-encephalopathy.html

BSE YOUNGEST AGE STATISTICS UNDER 30 MONTHS

http://bseyoungestage.blogspot.com/

Increased Atypical Scrapie Detections

Press reports indicate that increased surveillance is catching what otherwise would have been unreported findings of atypical scrapie in sheep. In 2009, five new cases have been reported in Quebec, Ontario, Alberta, and Saskatchewan. With the exception of Quebec, all cases have been diagnosed as being the atypical form found in older animals. Canada encourages producers to join its voluntary surveillance program in order to gain scrapie-free status. The World Animal Health will not classify Canada as scrapie-free until no new cases are reported for seven years. The Canadian Sheep Federation is calling on the government to fund a wider surveillance program in order to establish the level of prevalence prior to setting an eradication date. Besides long-term testing, industry is calling for a compensation program for farmers who report unusual deaths in their flocks.

http://gain.fas.usda.gov/Recent%20GAIN%20Publications/This%20Week%20in%20Canadian%20Agriculture%20%20%20%20%20Issue%2028_Ottawa_Canada_11-6-2009.pdf

Thursday, December 22, 2011

Chronic Wasting Disease discovered on game farm Saskatchewan Wednesday Dec. 21, 2011

http://chronic-wasting-disease.blogspot.com/2011/12/chronic-wasting-disease-discovered-on.html

PRIONET CANADA Canada’s prion research network Annual Report 2010 / 2011

http://www.prionetcanada.ca/files/PrioNet_AR2011_ONLINE_ENG_100dpi_max.pdf596.pdf

USA

J Vet Diagn Invest 21:454-463 (2009)

Nor98 scrapie identified in the United States

Christie M. Loiacono,' Bruce V. Thomsen, S. Mark Hall, Matti Kiupe!, Diane Sutton, Katherine O'Rourke, Bradd Barr, Lucy Anthenill, Deiwyn Keane

Abstract.

A distinct strain of scrapic identified in sheep of Norway in 1998 has since been identified in numerous countries throughout Europe. The disease is known as Nor98 or Not-98-like scrapic. among other names. Distinctions between classic scrapie and Nor98 scrapie are made based on histopathologv and immunodiagnostic results. There are also differences in the epidemiology, typical signalment, and likelihood of clinical signs being observed. In addition, sheep that have genotypes associated with resistance to classic scrapie are not spared from Nor98 disease. The various differences between classic and Nor98 scrapie have been consistently reported in the vast majority of cases described across Europe. The current study describes in detail the patholo gic changes and diagnostic results of the first 6 cases of' Nor98 scrapic disease diagnosed in sheep of the United States.

Key words: Hisiopathology: Nor98: PrP imniunolabeling; scrapie: sheep.

snip...

Results

Case I

The first case identified as consistent with Nor98 scrapie had nonclassic PrP distribution in brain tissue, no PrPSC in lymph tissue, and nonclassic migration of protein bands on a Western blot test. The animal was an aged, mottled-faced ewe that was traced back to a commercial flock in Wyoming. ...

Case 2

The second case was a clinically normal 8-year-old Suffolk ewe that had been in a quarantined flock for 5 years at a USDA facility in Iowa.

Case 3

A 16-year-old, white-faced, cross-bred wether was born to a black-faced ewe. He lived his entire life as a pet on a farm in California.

Case 4

The fourth case of Nor98 scrapie was identified in an approximately 8-year-old Dorset ewe that was born into a flock of approximately 20 ewes in Indiana.

Case 5

The fifth case was a clinically normal, approximately 3-year-old, white-faced, cross-bred ewe from an approximately 400 head commercial flock in Minnesota.

Case 6

The sixth case of Nor98 scrapie was identified in a 4-year-old, white-faced ewe that was purchased and added to a commercial flock in Pennsylvania

snip...

see full text ;

http://ddr.nal.usda.gov/bitstream/10113/33943/1/IND44241920.pdf

Scrapie Nor-98 like case in California FY 2011 AS of December 31, 2010.

Scrapie cases in goats FY 2002 - 2011 AS of December 31, 2010 Total goat cases = 21 Scrapie cases, 0 Nor-98 like Scrapie cases (21 field cases, 0 RSSS cases)

Last herd with infected goats disignated in FY 2008 Michigan 8 cases

http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps

UPDATE PLEASE NOTE ;

AS of June 30, 2011,

snip...

INCLUDING 10 POSITIVE GOATS FROM THE SAME HERD (FIGURE 7).

snip...

see updated APHIS scrapie report ;

http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps

Tuesday, February 01, 2011

Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie

Research article

snip...

Date: Tuesday, February 01, 2011 5:03 PM

To: Mr Terry Singeltary

Subject: Your comment on BMC Veterinary Research 2011, 7:7

Dear Mr Singeltary

Thank you for contributing to the discussion of BMC Veterinary Research 2011, 7:7 .

Your comment will be posted within 2 working days, as long as it contributes to the topic under discussion and does not breach patients' confidentiality or libel anyone. You will receive a further notification by email when the posting appears on the site or if it is rejected by the moderator.

Your posting will read:

Mr Terry Singeltary, retired Scrapie cases Goats from same herd USA Michigan

Comment: " In spite of the poorly defined effects of PRNP genetics, scrapie strain, dose, route and source of infection, the caprine placenta may represent a source of infection to progeny and herd mates as well as a source of persistent environmental contamination. "

Could this route of infection be the cause of the many cases of Goat scrapie from the same herd in Michigan USA ?

Has this been investigated ?

(Figure 6) including five goat cases in FY 2008 that originated from the same herd in Michigan. This is highly unusual for goats, and I strenuously urge that there should be an independent investigation into finding the common denominator for these 5 goats in the same herd in Michigan with Scrapie. ...

Kind Regards, Terry

In FY 2010, 72 cases of classical Scrapie and 5 cases of Nor-98 like Scrapie were confirmed...

http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/yearly_report.ppsx

Scrapie Nor-98 like case in California FY 2011 AS of December 31, 2010.

Scrapie cases in goats FY 2002 - 2011 AS of December 31, 2010 Total goat cases = 21 Scrapie cases, 0 Nor-98 like Scrapie cases (21 field cases, 0 RSSS cases)

Last herd with infected goats disignated in FY 2008 Michigan 8 cases

http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps

Thursday, January 07, 2010

Scrapie and Nor-98 Scrapie November 2009 Monthly Report Fiscal Year 2010 and FISCAL YEAR 2008

http://scrapie-usa.blogspot.com/2010/01/scrapie-and-nor-98-scrapie-november.html

Wednesday, January 18, 2012

Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural Scrapie Isolates Similar to CH1641 Experimental Scrapie

Journal of Neuropathology & Experimental Neurology:

February 2012 - Volume 71 - Issue 2 - p 140–147

http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/selection-of-distinct-strain-phenotypes.html

Wednesday, January 11, 2012

Bucks for brains on offer to cattle and sheep producers Queensland TSE PRION TESTING

http://usdameatexport.blogspot.com/2012/01/bucks-for-brains-on-offer-to-cattle-and.html

Wednesday, February 16, 2011

IN CONFIDENCE

SCRAPIE TRANSMISSION TO CHIMPANZEES

IN CONFIDENCE

http://scrapie-usa.blogspot.com/2011/02/in-confidence-scrapie-transmission-to.html

Sunday, April 18, 2010

SCRAPIE AND ATYPICAL SCRAPIE TRANSMISSION STUDIES A REVIEW 2010

http://scrapie-usa.blogspot.com/2010/04/scrapie-and-atypical-scrapie.html

Monday, April 25, 2011

Experimental Oral Transmission of Atypical Scrapie to Sheep

Volume 17, Number 5-May 2011

http://nor-98.blogspot.com/2011/04/experimental-oral-transmission-of.html

Sunday, March 28, 2010

Nor-98 atypical Scrapie, atypical BSE, spontaneous TSE, trade policy, sound science ?

http://nor-98.blogspot.com/2010/03/nor-98-atypical-scrapie-atypical-bse.html

Monday, November 30, 2009

USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE

http://nor-98.blogspot.com/2009/11/usda-and-oie-collaborate-to-exclude.html

I strenuously urge the USDA and the OIE et al to revoke the exemption of the legal global trading of atypical Nor-98 scrapie TSE. ...TSS

Friday, February 11, 2011

Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues

http://nor-98.blogspot.com/2011/02/atypicalnor98-scrapie-infectivity-in.html

Wednesday, January 18, 2012

BSE IN GOATS CAN BE MISTAKEN FOR SCRAPIE

February 1, 2012

http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/bse-in-goats-can-be-mistaken-for.html

Wednesday, January 18, 2012

Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural Scrapie Isolates Similar to CH1641 Experimental Scrapie

Journal of Neuropathology & Experimental Neurology:

February 2012 - Volume 71 - Issue 2 - p 140–147

http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/selection-of-distinct-strain-phenotypes.html

atypical scrapie just MAY be contagious, and MAY, IN FACT, NOT be a spontaneous degenerative condition of older sheep, AND with science transmission studies to date, there is more evidence that typical scrapie MAY transmit to man. and to imagine that the USDA and the OIE now base their scientific human and animal risk factors on MAY FACTORS, is really unbelieveable, unacceptable, and shows just how corrupt this global TSE livestock food system is, thanks to the OIE and the USDA. ...TSS

P03.141

Aspects of the Cerebellar Neuropathology in Nor98

Gavier-Widén, D1; Benestad, SL2; Ottander, L1; Westergren, E1 1National Veterinary Insitute, Sweden; 2National Veterinary Institute,

Norway Nor98 is a prion disease of old sheep and goats. This atypical form of scrapie was first described in Norway in 1998. Several features of Nor98 were shown to be different from classical scrapie including the distribution of disease associated prion protein (PrPd) accumulation in the brain. The cerebellum is generally the most affected brain area in Nor98. The study here presented aimed at adding information on the neuropathology in the cerebellum of Nor98 naturally affected sheep of various genotypes in Sweden and Norway. A panel of histochemical and immunohistochemical (IHC) stainings such as IHC for PrPd, synaptophysin, glial fibrillary acidic protein, amyloid, and cell markers for phagocytic cells were conducted. The type of histological lesions and tissue reactions were evaluated. The types of PrPd deposition were characterized. The cerebellar cortex was regularly affected, even though there was a variation in the severity of the lesions from case to case. Neuropil vacuolation was more marked in the molecular layer, but affected also the granular cell layer. There was a loss of granule cells. Punctate deposition of PrPd was characteristic. It was morphologically and in distribution identical with that of synaptophysin, suggesting that PrPd accumulates in the synaptic structures. PrPd was also observed in the granule cell layer and in the white matter. The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.

***The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.

http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf

PR-26

NOR98 SHOWS MOLECULAR FEATURES REMINISCENT OF GSS

R. Nonno1, E. Esposito1, G. Vaccari1, E. Bandino2, M. Conte1, B. Chiappini1, S. Marcon1, M. Di Bari1, S.L. Benestad3, U. Agrimi1 1 Istituto Superiore di Sanità, Department of Food Safety and Veterinary Public Health, Rome, Italy (romolo.nonno@iss.it); 2 Istituto Zooprofilattico della Sardegna, Sassari, Italy; 3 National Veterinary Institute, Department of Pathology, Oslo, Norway

Molecular variants of PrPSc are being increasingly investigated in sheep scrapie and are generally referred to as "atypical" scrapie, as opposed to "classical scrapie". Among the atypical group, Nor98 seems to be the best identified. We studied the molecular properties of Italian and Norwegian Nor98 samples by WB analysis of brain homogenates, either untreated, digested with different concentrations of proteinase K, or subjected to enzymatic deglycosylation. The identity of PrP fragments was inferred by means of antibodies spanning the full PrP sequence. We found that undigested brain homogenates contain a Nor98-specific PrP fragment migrating at 11 kDa (PrP11), truncated at both the C-terminus and the N-terminus, and not N-glycosylated. After mild PK digestion, Nor98 displayed full-length PrP (FL-PrP) and N-glycosylated C-terminal fragments (CTF), along with increased levels of PrP11. Proteinase K digestion curves (0,006-6,4 mg/ml) showed that FL-PrP and CTF are mainly digested above 0,01 mg/ml, while PrP11 is not entirely digested even at the highest concentrations, similarly to PrP27-30 associated with classical scrapie. Above 0,2 mg/ml PK, most Nor98 samples showed only PrP11 and a fragment of 17 kDa with the same properties of PrP11, that was tentatively identified as a dimer of PrP11. Detergent solubility studies showed that PrP11 is insoluble in 2% sodium laurylsorcosine and is mainly produced from detergentsoluble, full-length PrPSc. Furthermore, among Italian scrapie isolates, we found that a sample with molecular and pathological properties consistent with Nor98 showed plaque-like deposits of PrPSc in the thalamus when the brain was analysed by PrPSc immunohistochemistry. Taken together, our results show that the distinctive pathological feature of Nor98 is a PrP fragment spanning amino acids ~ 90-155. This fragment is produced by successive N-terminal and C-terminal cleavages from a full-length and largely detergent-soluble PrPSc, is produced in vivo and is extremely resistant to PK digestion.

*** Intriguingly, these conclusions suggest that some pathological features of Nor98 are reminiscent of Gerstmann-Sträussler-Scheinker disease.

119

http://www.neuroprion.com/pdf_docs/conferences/prion2006/abstract_book.pdf

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes

Annick Le Dur*,?, Vincent Béringue*,?, Olivier Andréoletti?, Fabienne Reine*, Thanh Lan Laï*, Thierry Baron§, Bjørn Bratberg¶, Jean-Luc Vilotte?, Pierre Sarradin**, Sylvie L. Benestad¶, and Hubert Laude*,? +Author Affiliations

*Virologie Immunologie Moléculaires and ?Génétique Biochimique et Cytogénétique, Institut National de la Recherche Agronomique, 78350 Jouy-en-Josas, France; ?Unité Mixte de Recherche, Institut National de la Recherche Agronomique-Ecole Nationale Vétérinaire de Toulouse, Interactions Hôte Agent Pathogène, 31066 Toulouse, France; §Agence Française de Sécurité Sanitaire des Aliments, Unité Agents Transmissibles Non Conventionnels, 69364 Lyon, France; **Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France; and ¶Department of Pathology, National Veterinary Institute, 0033 Oslo, Norway

***Edited by Stanley B. Prusiner, University of California, San Francisco, CA (received for review March 21, 2005)

Abstract Scrapie in small ruminants belongs to transmissible spongiform encephalopathies (TSEs), or prion diseases, a family of fatal neurodegenerative disorders that affect humans and animals and can transmit within and between species by ingestion or inoculation. Conversion of the host-encoded prion protein (PrP), normal cellular PrP (PrPc), into a misfolded form, abnormal PrP (PrPSc), plays a key role in TSE transmission and pathogenesis. The intensified surveillance of scrapie in the European Union, together with the improvement of PrPSc detection techniques, has led to the discovery of a growing number of so-called atypical scrapie cases. These include clinical Nor98 cases first identified in Norwegian sheep on the basis of unusual pathological and PrPSc molecular features and "cases" that produced discordant responses in the rapid tests currently applied to the large-scale random screening of slaughtered or fallen animals. Worryingly, a substantial proportion of such cases involved sheep with PrP genotypes known until now to confer natural resistance to conventional scrapie. Here we report that both Nor98 and discordant cases, including three sheep homozygous for the resistant PrPARR allele (A136R154R171), efficiently transmitted the disease to transgenic mice expressing ovine PrP, and that they shared unique biological and biochemical features upon propagation in mice. *** These observations support the view that a truly infectious TSE agent, unrecognized until recently, infects sheep and goat flocks and may have important implications in terms of scrapie control and public health.

http://www.pnas.org/content/102/44/16031.abstract

Monday, December 1, 2008

When Atypical Scrapie cross species barriers

Authors

Andreoletti O., Herva M. H., Cassard H., Espinosa J. C., Lacroux C., Simon S., Padilla D., Benestad S. L., Lantier F., Schelcher F., Grassi J., Torres, J. M., UMR INRA ENVT 1225, Ecole Nationale Veterinaire de Toulouse.France; ICISA-INlA, Madrid, Spain; CEA, IBiTec-5, DSV, CEA/Saclay, Gif sur Yvette cedex, France; National Veterinary Institute, Postboks 750 Sentrum, 0106 Oslo, Norway, INRA IASP, Centre INRA de Tours, 3738O Nouzilly, France.

Content

Atypical scrapie is a TSE occurring in small ruminants and harbouring peculiar clinical, epidemiological and biochemical properties. Currently this form of disease is identified in a large number of countries. In this study we report the transmission of an atypical scrapie isolate through different species barriers as modeled by transgenic mice (Tg) expressing different species PRP sequence.

The donor isolate was collected in 1995 in a French commercial sheep flock. inoculation into AHQ/AHQ sheep induced a disease which had all neuro-pathological and biochemical characteristics of atypical scrapie. Transmitted into Transgenic mice expressing either ovine or PrPc, the isolate retained all the described characteristics of atypical scrapie.

Surprisingly the TSE agent characteristics were dramatically different v/hen passaged into Tg bovine mice. The recovered TSE agent had biological and biochemical characteristics similar to those of atypical BSE L in the same mouse model. Moreover, whereas no other TSE agent than BSE were shown to transmit into Tg porcine mice, atypical scrapie was able to develop into this model, albeit with low attack rate on first passage.

Furthermore, after adaptation in the porcine mouse model this prion showed similar biological and biochemical characteristics than BSE adapted to this porcine mouse model. Altogether these data indicate.

(i) the unsuspected potential abilities of atypical scrapie to cross species barriers

(ii) the possible capacity of this agent to acquire new characteristics when crossing species barrier

These findings raise some interrogation on the concept of TSE strain and on the origin of the diversity of the TSE agents and could have consequences on field TSE control measures.

http://www.neuroprion.org/resources/pdf_docs/conferences/prion2008/abstract-book-prion2008.pdf

http://nor-98.blogspot.com/

why do we not want to do TSE transmission studies on chimpanzees $

snip...

5. A positive result from a chimpanzee challenged severly would likely create alarm in some circles even if the result could not be interpreted for man. I have a view that all these agents could be transmitted provided a large enough dose by appropriate routes was given and the animals kept long enough. Until the mechanisms of the species barrier are more clearly understood it might be best to retain that hypothesis.

snip...

R. BRADLEY

http://collections.europarchive.org/tna/20080102222950/http://www.bseinquiry.gov.uk/files/yb/1990/09/23001001.pdf

1992

IN CONFIDENCE

BSE - ATYPICAL LESION DISTRIBUTION (RBSE 92-21367)

http://tna.europarchive.org/20080609145105/http://www.bseinquiry.gov.uk/files/yb/1993/03/14001001.pdf

1992

NEW BRAIN DISORDER

3. WHAT ABOUT REPORTS OF NEW FORM OF BSE ?

THE VETERINARY RECORD HAS PUBLISHED AN ARTICLE ON A NEW BRAIN DISORDER OF CATTLE DISCOVERED THROUGH OUR CONTROL MEASURES FOR BSE. ALTHOUGH IT PRESENTS SIMILAR CLINICAL SIGNS TO BSE THERE ARE MAJOR DIFFERENCES IN HISTOPATHOLOGY AND INCUBATION PERIODS BETWEEN THE TWO. MUST EMPHASISE THAT THIS IS _NOT_ BSE.

4. IS THIS NEW BRAIN DISORDER A THREAT ?

WE DO NOT EVEN KNOW WHETHER THE AGENT OF THIS DISEASE IS TRANSMISSIBLE. IN ANY CASE, CASES SO FAR IDENTIFIED HAD SHOWN SIMILAR SYMPTOMS TO THOSE OF BSE, AND THEREFORE HAVE BEEN SLAUGHTERED AND INCINERATED, SO THAT IF A TRANSMISSIBLE AGENT WERE INVOLVED IT WOULD HAVE BEEN ELIMINATED. ...

http://collections.europarchive.org/tna/20090114131343/http://www.bseinquiry.gov.uk/files/yb/1992/10/26001001.pdf

Tuesday, November 17, 2009

SEAC NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS (IBNC) FROM THE VETERINARY LABORATORIES AGENCY (VLA) SEAC 103/1

http://bse-atypical.blogspot.com/2009/11/seac-new-results-on-idiopathic.html

NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS

"All of the 15 cattle tested showed that the brains had abnormally accumulated PrP"

2009

http://bse-atypical.blogspot.com/2009/02/new-results-on-idiopathic-brainstem.html

''THE LINE TO TAKE'' ON IBNC $$$ 1995 $$$

1995

page 9 of 14 ;

30. The Committee noted that the results were unusual. the questioned whether there could be coincidental BSE infection or contamination with scrapie. Dr. Tyrell noted that the feeling of the committee was that this did not represent a new agent but it was important to be prepared to say something publicly about these findings. A suggested line to take was that these were scientifically unpublishable results but in line with the policy of openness they would be made publicly available and further work done to test their validity. Since the BSE precautions were applied to IBNC cases, human health was protected. Further investigations should be carried out on isolations from brains of IBNC cases with removal of the brain and subsequent handling under strict conditions to avoid the risk of any contamination.

31. Mr. Bradley informed the Committee that the CVO had informed the CMO about the IBNC results and the transmission from retina and he, like the Committee was satisfied that the controls already in place or proposed were adequate. ...

snip... see full text

http://collections.europarchive.org/tna/20080102204938/http://www.bseinquiry.gov.uk/files/yb/1995/06/21005001.pdf

http://web.archive.org/web/20030327015011/http://www.bseinquiry.gov.uk/files/yb/1995/06/21005001.pdf

Wednesday, July 28, 2010

Atypical prion proteins and IBNC in cattle DEFRA project code SE1796 FOIA Final report

http://bse-atypical.blogspot.com/2010/07/atypical-prion-proteins-and-ibnc-in.html

IN CONFIDENCE

BSE ATYPICAL LESION DISTRIBUTION

http://web.archive.org/web/20041226015813/http://www.bseinquiry.gov.uk/files/yb/1993/03/14001001.pdf

Tuesday, November 02, 2010

BSE - ATYPICAL LESION DISTRIBUTION (RBSE 92-21367) statutory (obex only) diagnostic criteria CVL 1992

http://bse-atypical.blogspot.com/2010/11/bse-atypical-lesion-distribution-rbse.html

Thursday, June 23, 2011

Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/experimental-h-type-bovine-spongiform.html

Saturday, June 25, 2011

Transmissibility of BSE-L and Cattle-Adapted TME Prion Strain to Cynomolgus Macaque

"BSE-L in North America may have existed for decades"

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/transmissibility-of-bse-l-and-cattle.html

Sunday, June 26, 2011

Risk Analysis of Low-Dose Prion Exposures in Cynomolgus Macaque

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/risk-analysis-of-low-dose-prion.html

Friday, December 23, 2011

Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

Volume 18, Number 1—January 2012 Dispatch

http://transmissiblespongiformencephalopathy.blogspot.com/2011/12/oral-transmission-of-l-type-bovine.html

Saturday, November 19, 2011

Novel Prion Protein in BSE-affected Cattle, Switzerland

http://transmissiblespongiformencephalopathy.blogspot.com/2011/11/novel-prion-protein-in-bse-affected.html

Owens, Julie

From: Terry S. Singeltary Sr. [flounder9@verizon.net]

Sent: Monday, July 24, 2006 1:09 PM

To: FSIS RegulationsComments

Subject: [Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine Spongiform Encephalopathy (BSE)

Page 1 of 98

http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf

FSIS RFEPLY TO TSS ;

Harvard Risk Assessment of Bovine Spongiform Encephalopathy Update, October 31, 2005 INTRODUCTION The United States Department of Agriculture’s Food Safety and Inspection Service (FSIS) held a public meeting on July 25, 2006 in Washington, D.C. to present findings from the Harvard Risk Assessment of Bovine Spongiform Encephalopathy Update, October 31, 2005 (report and model located on the FSIS website:

http://www.fsis.usda.gov/Science/Risk_Assessments/index.asp).

Comments on technical aspects of the risk assessment were then submitted to FSIS. Comments were received from Food and Water Watch, Food Animal Concerns Trust (FACT), Farm Sanctuary, R-CALF USA, Linda A Detwiler, and Terry S. Singeltary. This document provides itemized replies to the public comments received on the 2005 updated Harvard BSE risk assessment. Please bear the following points in mind:

http://www.fsis.usda.gov/PDF/BSE_Risk_Assess_Response_Public_Comments.pdf

Saturday, June 19, 2010

U.S. DENIED UPGRADED BSE STATUS FROM OIE

http://usdameatexport.blogspot.com/2010/06/us-denied-upgraded-bse-status-from-oie.html

Friday, August 20, 2010

USDA: Animal Disease Traceability August 2010

http://naiscoolyes.blogspot.com/2010/08/usda-animal-disease-traceability-august.html

Friday, November 18, 2011

country-of-origin labeling law (COOL) violates U.S. obligations under WTO rules WT/DS384/R WT/DS386/R

http://naiscoolyes.blogspot.com/2011/11/country-of-origin-labeling-law-cool.html

http://naiscoolyes.blogspot.com/

Saturday, July 23, 2011

CATTLE HEADS WITH TONSILS, BEEF TONGUES, SPINAL CORD, SPECIFIED RISK MATERIALS (SRM's) AND PRIONS, AKA MAD COW DISEASE

http://transmissiblespongiformencephalopathy.blogspot.com/2011/07/cattle-heads-with-tonsils-beef-tongues.html

Saturday, November 6, 2010

TAFS1 Position Paper on Position Paper on Relaxation of the Feed Ban in the EU

Berne, 2010 TAFS INTERNATIONAL FORUM FOR TRANSMISSIBLE ANIMAL DISEASES AND FOOD SAFETY a non-profit Swiss Foundation

http://madcowfeed.blogspot.com/2010/11/tafs1-position-paper-on-position-paper.html

Archive Number 20101206.4364 Published Date 06-DEC-2010 Subject PRO/AH/EDR>

Prion disease update 2010 (11) PRION DISEASE UPDATE 2010 (11)

http://www.promedmail.org/direct.php?id=20101206.4364

Monday, January 16, 2012

9 GAME FARMS IN WISCONSIN TEST POSITIVE FOR CWD

http://chronic-wasting-disease.blogspot.com/2012/01/9-game-farms-in-wisconsin-test-positive.html

Tuesday, December 20, 2011

CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011

http://dnr.wi.gov/org/nrboard/2011/december/12-11-2b2.pdf

CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011

Form 1100-001

(R 2/11)

NATURAL RESOURCES BOARD AGENDA ITEM

SUBJECT: Inf01mation Item: Almond Deer Fatm Update

FOR: DECEIVIBER 2011 BOARD MEETING

SNIP...

These laboratory results show that 60 of the 76 animals tested positive for chronic wasting disease. The 76 deer constituted the breeding herd on Hall’s farm. He also operated a hunting preserve on the property until 2005. Four deer, two does and two fawns, the only deer remaining in the former preserve, were killed and tested as well. CWD was not detected in those animals. The total number of deer to test positive from this farm from the initial discovery to final depopulation is 82. The CWD infection rate was nearly 80%, the highest ever in a North American captive herd.

SNIP...

Despite the five year premise plan and site decontamination, The WI DNR has concerns over the bioavailability of infectious prions at this site to wild white-tail deer should these fences be removed. Current research indicates that prions can persist in soil for a minimum of 3 years. However, Georgsson et al. (2006) concluded that prions that produced scrapie disease in sheep remained bioavailable and infectious for at least 16 years in natural Icelandic environments, most likely in contaminated soil. Additionally, the authors reported that from 1978-2004, scrapie recurred on 33 sheep farms, of which 9 recurrences occurred 14-21 years after initial culling and subsequent restocking efforts; these findings further emphasize the effect of environmental contamination on sustaining TSE infectivity and that long-term persistence of prions in soils may be substantially greater than previously thought. Evidence of environmental transmission also was documented in a Colorado research facility where mule deer became infected with CWD in two of three paddocks where infected deer carcasses had decomposed on site 1.8 years earlier, and in one of three paddocks where infected deer had last resided 2.2 years earlier (Miller et al. 2004).

SNIP...

http://dnr.wi.gov/org/nrboard/2011/december/12-11-2b2.pdf

FULL TEXT AND MORE HERE ;

http://chronic-wasting-disease.blogspot.com/2011/12/chronic-wasting-disease-cwd-wisconsin.html

*** Spraker suggested an interesting explanation for the occurrence of CWD. The deer pens at the Foot Hills Campus were built some 30-40 years ago by a Dr. Bob Davis. At or abut that time, allegedly, some scrapie work was conducted at this site. When deer were introduced to the pens they occupied ground that had previously been occupied by sheep.

(PLEASE NOTE SOME OF THESE OLD UK GOVERNMENT FILE URLS ARE SLOW TO OPEN, AND SOMETIMES YOU MAY HAVE TO CLICK ON MULTIPLE TIMES, PLEASE BE PATIENT, ANY PROBLEMS PLEASE WRITE ME PRIVATELY, AND I WILL TRY AND FIX OR SEND YOU OLD PDF FILE...TSS)

http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf

http://chronic-wasting-disease.blogspot.com/

Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted USA Beef

By Terry S. Singeltary Sr.

May 15, 2008

Straight to the Source

http://www.grassrootsnetroots.org/articles/article_12387.cfm

Tuesday, May 13, 2008

Concerned Americans against Mad Cow Disease STATEMENT OF SOLIDARITY with Koreans May 13, 2008

http://usdavskorea.blogspot.com/2008/05/concerned-americans-against-mad-cow.html

Wednesday, February 10, 2010

The Honorable Ms. Kim Min-sun Anti-US Beef Actress Prevails in Court

http://usdavskorea.blogspot.com/2010/02/honorable-ms-kim-min-sun-anti-us-beef.html

Saturday, April 10, 2010

TOYOTA VS MAD COW DISEASE USA OIE BSE MRR IMPORT AND EXPORT TRADE WARS

http://usdameatexport.blogspot.com/2010/04/toyota-vs-mad-cow-disease-usa-oie-bse.html

http://usdavskorea.blogspot.com/

Tuesday, November 08, 2011

Can Mortality Data Provide Reliable Indicators for Creutzfeldt-Jakob Disease Surveillance? A Study in France from 2000 to 2008

Vol. 37, No. 3-4, 2011 Original Paper Conclusions:These findings raise doubt about the possibility of a reliable CJD surveillance only based on mortality data.

http://creutzfeldt-jakob-disease.blogspot.com/2011/11/can-mortality-data-provide-reliable.html

Terry S. Singeltary Sr. on the Creutzfeldt-Jakob Disease Public Health Crisis

http://www.youtube.com/watch?v=zf3lfz9NrT4

http://www.youtube.com/watch?v=c0tWkNvhO4g

http://www.youtube.com/watch?v=zf3lfz9NrT4&feature=results_main&playnext=1&list=PL780BE2AF0B62A944

full text with source references ;

http://transmissiblespongiformencephalopathy.blogspot.com/2011/08/terry-singeltary-sr-on-creutzfeldt.html

Monday, September 26, 2011

L-BSE BASE prion and atypical sporadic CJD

http://bse-atypical.blogspot.com/2011/09/l-bse-base-prion-and-atypical-sporadic.html

Saturday, March 5, 2011

MAD COW ATYPICAL CJD PRION TSE CASES WITH CLASSIFICATIONS PENDING ON THE RISE IN NORTH AMERICA

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/mad-cow-atypical-cjd-prion-tse-cases.html

CANADA CJD UPDATE 2011

CJD Deaths Reported by CJDSS1, 1994-20112 As of January 31, 2011

3. Final classification of 49 cases from 2009, 2010, 2011 is pending.

snip...

http://www.phac-aspc.gc.ca/hcai-iamss/cjd-mcj/cjdss-ssmcj/pdf/stats_0111-eng.pdf

USA 2011

USA

National Prion Disease Pathology Surveillance Center

Cases Examined1

(November 1, 2010)

Year Total Referrals2 Prion Disease Sporadic Familial Iatrogenic vCJD

1996 & earlier 51 33 28 5 0 0

1997 114 68 59 9 0 0

1998 87 51 43 7 1 0

1999 121 73 65 8 0 0

2000 146 103 89 14 0 0

2001 209 119 109 10 0 0

2002 248 149 125 22 2 0

2003 274 176 137 39 0 0

2004 325 186 164 21 0 13

2005 344 194 157 36 1 0

2006 383 197 166 29 0 24

2007 377 214 187 27 0 0

2008 394 231 205 25 0 0

2009 425 258 215 43 0 0

2010 333 213 158 33 0 0

TOTAL 38315 22656 1907 328 4 3

1 Listed based on the year of death or, if not available, on year of referral;

2 Cases with suspected prion disease for which brain tissue and/or blood (in familial cases) were submitted;

3 Disease acquired in the United Kingdom;

4 Disease was acquired in the United Kingdom in one case and in Saudi Arabia in the other case;

5 Includes 18 cases in which the diagnosis is pending, and 18 inconclusive cases;

6 Includes 23 (22 from 2010) cases with type determination pending in which the diagnosis of vCJD has been excluded.

http://www.cjdsurveillance.com/pdf/case-table.pdf

Please notice where sporadic CJD cases in 1996 went from 28 cases, to 215 cases in 2009, the highest recorded year to date. sporadic CJD is on a steady rise, and has been since 1996.

I also urge you to again notice these disturbing factors in lines 5 and 6 ;

5 Includes 18 cases in which the diagnosis is pending, and 18 inconclusive cases;

6 Includes 23 (22 from 2010) cases with type determination pending in which the diagnosis of vCJD has been excluded.

========end=====tss=====2011

Monday, August 9, 2010

National Prion Disease Pathology Surveillance Center Cases Examined (July 31, 2010)

(please watch and listen to the video and the scientist speaking about atypical BSE and sporadic CJD and listen to Professor Aguzzi)

http://prionunitusaupdate2008.blogspot.com/2010/08/national-prion-disease-pathology.html

THE steady rise of sporadic CJD cases in Canada AND USA, with many unusual cases of ''PENDING CLASSIFICATIONS" which have been pending now FOR 3 YEARS. HOW long can this cover-up continue $$$

The most recent assessments (and reassessments) were published in June 2005 (Table I; 18), and included the categorisation of Canada, the USA, and Mexico as GBR III. Although only Canada and the USA have reported cases, the historically open system of trade in North America suggests that it is likely that BSE is present also in Mexico.

http://www.oie.int/boutique/extrait/06heim937950.pdf

SEE FULL TEXT AND MORE HERE ;

Envt.15:

Prediction for Potential Risk Factors Through the Association Study Between Epidemiological Data and SNPs of Prion Protein Gene in the Korean Population and Suspected CJD Patients

Suyeon Kim,† Sol Moe Lee, Jae Wook Hyeon, Bo-Yeong Choi, Chi-Kyeong Kim, Jun Sun Park and Young Ran Ju

National Institute of Health, Korea CDC; Cheongwongun, Chungcheongbukdo, Korea;†Presenting author; Email: tenksy@nih.go.kr

Cases of the suspected CJD patients and reports of probable CJD have been increased due to a social uneasiness for import permission of beef from western countries reported BSE outbreak since 2008 in Korea CDC. It has been hard to definite diagnosis them due to Korean funeral culture though reports of probable sporadic CJD and genetic CJD have been increased in Korea. First of all, we need to clear the characteristics of PRNP gene in Korean population and to analyze the association between the endemic environmental factors and SNPs of the gene to predict the underlying cause.

We sequenced up to 5kb of the genomic region including the promoter region, exon I and exon II to analyze the correlation between SNPs of 185 suspected patients and diagnostic factors, and between SNPs of PRNP gene of 296 normal population and 60 epidemiologic factors like medical and familial history and diet. General statistical analyses were carried out by using SPSS statistic 18 (SPSS Inc., NY). Their significance levels were determined by the chi-square test (Fisher’s exact test).

We identified 19 SNPs in normal group and 15 SNPs gene in suspected patients’ group in their promoter and exon II regions. Our statistic analyses demonstrated that between rs1799990 (+385A>G; 129MV), rs28933385 (+598A>G; 200EK) and patient factors in suspected patients’ group showed significantly. In normal population group, between rs2756271 (-14605A>G), rs73612131 (-13537A>T), -14409 (C>T), rs1800014 (+655A>G; 219EK), +695(T>G; 232MR) and +591 (C>T; 197NN) SNPs and several demographic and dietary factors like an intake frequency of beef or ham were significantly associated.

In this study, we could predict the potential risk factors through the association study between SNPs of PRNP gene and several epidemiological factors. Especially, significance level of some dietary habits might show higher than other factors. However, we cannot entirely decide them risk factors of genetic markers in prion disease without identification of environmental or other causes of definite CJD patients though we found de novo SNP and significant result of PRNP. We expect to elucidate clearly their association through the combination of our results with other clinical information including additional clues.

PRION 2011

http://www.prion2011.ca/files/PRION_2011_Timetable-ENG_(May_5-11).pdf

landesbioscience.com

Wednesday, November 30, 2011

First iCJD Death Confirmed in Korea

http://creutzfeldt-jakob-disease.blogspot.com/2011/11/first-icjd-death-confirmed-in-korea.html

Monday, December 12, 2011

Second iatrogenic CJD case confirmed Korea

http://creutzfeldt-jakob-disease.blogspot.com/2011/12/second-iatrogenic-cjd-case-confirmed.html

Saturday, January 21, 2012

Quick facts about mad cow disease

http://transmissiblespongiformencephalopathy.blogspot.com/2012/01/quick-facts-about-mad-cow-disease.html

layperson

Terry S. Singeltary Sr.

P.O. Box 42

Bacliff, Texas USA 77518

flounder9@verizon.net

S. Korea confirms second case of iatrogenic Creutzfeldt-Jakob disease 48-year-old man

2011-12-08T11:25:00.000-08:00

2011/12/08 11:08 KST

S. Korea confirms second case of Creutzfeldt-Jakob disease

SEOUL, Dec. 8 (Yonhap) -- South Korea's health authorities on Thursday confirmed the country's second case of Creutzfeldt-Jakob disease (CJD), a degenerative neurological disorder.

A 48-year-old man was diagnosed with iatrogenic CJD (iCJD) on Wednesday, according to the Center for Disease Control. The person's identity was withheld for privacy reasons.

The report of the country's second-ever iCJD case comes after a 54-year-old woman was found last month to have died from the same disease that is often transmitted by the use of defective prion proteins found in surgical tissue graft products.

The woman had received brain surgery using Lyodura, a tissue graft product, some 23 years ago. The KCDC said the man in the latest case had also received Lyodura during brain surgery in 1988.

This form of CJD has an incubation period of more than 20 years but once symptoms occur, death usually takes place within a year.

CJD is the most common of so-called human prion diseases with one person in every 1 million diagnosed each year worldwide. It is an invariably fatal illness with death occurring after the onset of dementia, hallucinations, coordination dysfunction and seizures.

The animal form of the disease is called bovine spongiform encephalopathy (BSE) which is commonly called mad cow disease. BSE also leaves holes in the brain that resemble a sponge.

bdk@yna.co.kr

(END)

http://english.yonhapnews.co.kr/business/2011/12/08/51/0502000000AEN20111208002700320F.HTML

Envt.15:

Prediction for Potential Risk Factors Through the Association Study Between Epidemiological Data and SNPs of Prion Protein Gene in the Korean Population and Suspected CJD Patients

Suyeon Kim,† Sol Moe Lee, Jae Wook Hyeon, Bo-Yeong Choi, Chi-Kyeong Kim, Jun Sun Park and Young Ran Ju

National Institute of Health, Korea CDC; Cheongwongun, Chungcheongbukdo, Korea;†Presenting author; Email: tenksy@nih.go.kr

Cases of the suspected CJD patients and reports of probable CJD have been increased due to a social uneasiness for import permission of beef from western countries reported BSE outbreak since 2008 in Korea CDC. It has been hard to definite diagnosis them due to Korean funeral culture though reports of probable sporadic CJD and genetic CJD have been increased in Korea. First of all, we need to clear the characteristics of PRNP gene in Korean population and to analyze the association between the endemic environmental factors and SNPs of the gene to predict the underlying cause.

We sequenced up to 5kb of the genomic region including the promoter region, exon I and exon II to analyze the correlation between SNPs of 185 suspected patients and diagnostic factors, and between SNPs of PRNP gene of 296 normal population and 60 epidemiologic factors like medical and familial history and diet. General statistical analyses were carried out by using SPSS statistic 18 (SPSS Inc., NY). Their significance levels were determined by the chi-square test (Fisher’s exact test).

We identified 19 SNPs in normal group and 15 SNPs gene in suspected patients’ group in their promoter and exon II regions. Our statistic analyses demonstrated that between rs1799990 (+385A>G; 129MV), rs28933385 (+598A>G; 200EK) and patient factors in suspected patients’ group showed significantly. In normal population group, between rs2756271 (-14605A>G), rs73612131 (-13537A>T), -14409 (C>T), rs1800014 (+655A>G; 219EK), +695(T>G; 232MR) and +591 (C>T; 197NN) SNPs and several demographic and dietary factors like an intake frequency of beef or ham were significantly associated.

In this study, we could predict the potential risk factors through the association study between SNPs of PRNP gene and several epidemiological factors. Especially, significance level of some dietary habits might show higher than other factors. However, we cannot entirely decide them risk factors of genetic markers in prion disease without identification of environmental or other causes of definite CJD patients though we found de novo SNP and significant result of PRNP. We expect to elucidate clearly their association through the combination of our results with other clinical information including additional clues.

PRION 2011

http://www.prion2011.ca/files/PRION_2011_Timetable-ENG_(May_5-11).pdf

landesbioscience.com

Wednesday, November 30, 2011

First iCJD Death Confirmed in Korea

http://creutzfeldt-jakob-disease.blogspot.com/2011/11/first-icjd-death-confirmed-in-korea.html

tss

Supreme Court clears ‘PD Notebook’ of distortion over USA MAD COW CONTROVERSY

2011-09-02T09:40:00.000-07:00

Supreme Court clears ‘PD Notebook’ of distortion over USA MAD COW CONTROVERSY

Supreme Court clears ‘PD Notebook’ of distortion

2011-09-02 20:52

The Supreme Court on Friday cleared the directors of nationwide broadcaster MBC’s investigative program, “PD Notebook,” of charges that they had distorted some content regarding mad cow disease in the U.S.

The court upheld the Seoul High Court’s decision ruling them not guilty of defaming former Minister of Food, Agriculture, Forestry and Fisheries, Chung Woon-chun, through the program.

The producers on April 29, 2008 suggested in its program that people who consume U.S. beef could contract the human form of “mad cow disease” and showed a video clip of “downer” cows at U.S. farms. They also said that the Korean government was either ignorant of this or had intentionally turned a blind eye to it to proceed with the import resumption.

The news inspired nearly 2 million people to rally against the Lee Myung-bak administration’s decision to resume U.S. beef imports, and caused Lee’s approval rating to plummet.

A separate full panel of the Supreme Court on the same day remanded the Seoul High Court’s order that the program makers air apologetic and correctional content.

Through investigation, which involved the arrest of five directors, a raid into the office and seizure of the original films, the prosecutors claimed that several parts of the interview scenes were inaccurately translated, which could have misled the audience. MBC swiftly offered an apology.

A local court ordered the directors to air that “downer cows” do not necessary have bovine spongiform encephalopathy.

It also ruled that the contents alleging that Koreans are more susceptible to Creutzfeldt-Jakob Disease (human mad cow disease) and that the government has authorized the imports of five especially risky materials in regards to the CJD are false. A high court also ruled that MBC must air the government messages.

The court’s Friday rulings in favor of the PD Notebook could be referred as the judiciary’s guaranteeing the rights to express, observers said.

The prosecution’s rows of “excessive investigation” into the program ignited fierce disputes over the journalistic freedom and whether the government could interfere even if it contains errors.

In 2010, a local court rejected a collective lawsuit by nearly 2,500 people against the program for destabilizing the country through the “distorted reports.”

The Seoul Southern District Court said that the information may have been partially inaccurate, but its producers could not be responsible for the protests driven by the program.

By Bae Ji-sook (baejisook@heraldm.com)

http://www.koreaherald.com/national/Detail.jsp?newsMLId=20110902000758

seems the only distortion (lies), comes from the USDA et al. ...tss

Saturday, June 25, 2011

Transmissibility of BSE-L and Cattle-Adapted TME Prion Strain to Cynomolgus Macaque

Emmanuel Comoy,1,† Valérie Durand,1 Evelyne Correia,1 Sophie Freire,1 Jürgen Richt,2 Justin Greenlee,3 Juan-Maria Torres,4 Paul Brown,1 Bob Hills5 and Jean-Philippe Deslys1

1Atomic Energy Commission; Fontenay-aux-Roses, France; 2Kansas State University; Manhattan, KS USA; 3USDA; Ames, IA USA; 4INIA; Madrid, Spain; 5Health Canada; Ottawa, ON Canada†Presenting author; Email: emmanuel.comoy@cea.fr

The epidemiology of Transmissible mink encephalopathy (TME) indicates an alimentary origin. Several inter-species transmission experiments have not succeeded in establishing with certainty any natural reservoir of this prion strain, although both ovine and bovine sources have been suspected. Cattle exposed to TME develop a spongiform encephalopathy that is distinct from classical Bovine Spongiform Encephalopathy (c-BSE).

Inoculation of c-BSE to cynomolgus macaque provided early evidence of a possible risk to humans, and remains an important model to define the risk of both primary (oral transmission from cattle to primate) and secondary (intravenous intra-species transmission) exposures. We have also evaluated the transmissibility of other cattle prion strains to macaques, including L- and H- atypical forms of BSE, namely BSE-L and BSE-H, and cattle-adapted TME.

BSE-L induced a neurological disease distinct from c-BSE. Peripheral exposures demonstrate the transmissibility of BSE-L by oral, intravenous, and intra-cerebral routes, with incubation periods similar to c-BSE. Cattle-adapted TME also induced a rapid disease in cynomolgus macaque. The clinical features, lesion profile, and biochemical signature of the induced disease was similar to the features observed in animals exposed to BSE-L, suggesting a link between the two prion strains. Secondary transmissions to a common host (transgenic mouse overexpressing bovine PrP) of cattle-TME and BSE-L before or after passage in primates induced diseases with similar incubation periods: like the c-BSE strain, these cattle strains maintained their distinctive features regardless of the donor species and passages.

If the link between TME and BSE-L is confirmed, our results would suggest that BSE-L in North America may have existed for decades, and highlight a possible preferential transmission of animal prion strains to primates after passage in cattle.

=====================end...tss====================

Risk.16: Clinical Disease in Cattle Experimentally Inoculated with All Types of BSE

Catherine Graham,1,† Michel Levy,2 Ed Pajor,2 Garth McGregor,1 Rheana Flitton1 and Stefanie Czub1

1Canadian Food Inspection Agency; Lethbridge, AB Canada; 2Faculty of Veterinary Medicine; University of Calgary; Calgary, AB Canada†Presenting author; Email: catherine.graham@inspection.gc.ca

Background. Classical, or C-type, bovine spongiform encephalopathy (BSE) has been extensively described in the literature. Recently, two novel forms of BSE, termed atypical BSE, have been reported in a number of countries. These new forms show differences in the biochemical characteristics of the prion protein and, where reported, tend to occur in aged animals but descriptions of clinical presentation are incomplete or absent.

Materials and Methods. Female Hereford/Angus cross calves were intracranially challenged at approximately five months of age with 1 ml of a 10% brain homogenate originating from Canadian field cases of BSE which had been previously classified as C-, L-, or H- type.

The animals were monitored during incubation period, and clinical disease is described using a standardized examination protocol. Incubation period, description and progression of clinical signs was recorded and videotaped for objective evaluation.

Results. All L- and H- type atypical BSE challenged animals began to display signs of clinical disease at approximately 11 months post inoculation, and disease progression was slow but constant until animals were euthanized. Clinical signs in all atypical BSE inoculated animals included hesitation at doors and gates, spontaneous muscle fasciculations and sensitivity to touch. Teeth grinding and excessive salivation are occasionally noted. Animals with L-type BSE are very anxious and show high levels of sensitivity to hand movement. One H-type animal shows periods of somnolence. Both H-type inoculated animals go down during handling and have difficulty rising and show sensitivity to movement around their head and neck area, but to a lesser degree than the L-type BSE inoculated animals. Interestingly, no locomotor abnormalities have been observed in either group.

C-type challenged animals remain normal at approximately 18 months post inoculation. Clinical disease in C-type inoculated animals from a previous transmission study was typically slow and intermittently displayed during the initial stages and after a period of two to four months was more consistent and progressive. Clinical signs in C-type BSE were as previously reported in the literature.

Discussion. The spectrum of clinical signs for all three types of BSE examined is similar. Incubation period is shorter for H- and L-type BSE as compared with C-type. Once clinical signs begin, progression is slow but relentless in atypical BSE, and more insidious in classical BSE. A summary of clinical signs presented in the three different types of BSE will be presented, and video of clinical disease will be displayed.

link url not available, please see PRION 2011 ;

http://www.prion2011.ca/files/PRION_2011_-_Posters_(May_5-11).pdf

=========================end...tss================

PLEASE NOTE *

Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME.

snip...

The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...

http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf

snip...see full text ;

Saturday, June 25, 2011

Transmissibility of BSE-L and Cattle-Adapted TME Prion Strain to Cynomolgus Macaque

"BSE-L in North America may have existed for decades"

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/transmissibility-of-bse-l-and-cattle.html

Sunday, June 26, 2011

Risk Analysis of Low-Dose Prion Exposures in Cynomolgus Macaque

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/risk-analysis-of-low-dose-prion.html

Thursday, June 23, 2011

Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/experimental-h-type-bovine-spongiform.html

Wednesday, June 15, 2011

Galveston, Texas - Isle port moves through thousands of heifers headed to Russia, none from Texas, Alabama, or Washington, due to BSE risk factor

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/galveston-texas-isle-port-moves-through.html

Sunday, September 6, 2009

MAD COW USA 1997 SECRET VIDEO

http://madcowusda.blogspot.com/2009/09/mad-cow-usa-1997-video.html

Wednesday, February 10, 2010

The Honorable Ms. Kim Min-sun Anti-US Beef Actress Prevails in Court

http://usdavskorea.blogspot.com/2010/02/honorable-ms-kim-min-sun-anti-us-beef.html

Tuesday, June 17, 2008

Portsmouth woman did not die of mad cow-related condition, USDA says

UPDATE Updated Jun.17, 2008 08:34 KST

http://cjdmadcowbaseoct2007.blogspot.com/2008/06/portsmouth-woman-did-not-die-of-mad-cow.html

Aretha N. Vinson

Portsmouth woman did not die of mad cow-related condition, ___USDA___ says

By Nancy Young The Virginian-Pilot © May 7, 2008

http://nor-98.blogspot.com/2010/03/nor-98-atypical-scrapie-atypical-bse.html

Korea data on PD Notebook

http://usdavskorea.blogspot.com/2008/06/south-korea-bans-rallies-against-us.html

Saturday, August 22, 2009

FREE Kim Min-sun, she is correct about mad cow fears from USDA BEEF

http://usdavskorea.blogspot.com/2009/08/free-kim-min-sun-she-is-correct-about.html

Friday, May 9, 2008

USDA VS KOREA typical or atypical BSe

http://usdavskorea.blogspot.com/2008/05/usda-vs-korea-typical-or-atypical-bse.html

Tuesday, April 14, 2009

Tons of USA Beef Suspected of Mad Cow Disease Sold KOREA

http://usdavskorea.blogspot.com/2009/04/tons-of-usa-beef-suspected-of-mad-cow.html

June 11, 2008, 10:14PM

U.S. slams door on revising S. Korea beef

import pact Pressed at home, Seoul had wanted 30-month limit on age of the cattle

http://www.chron.com/disp/story.mpl/nation/5832282.html

http://usdavskorea.blogspot.com/2008/06/us-slams-door-on-revising-s-korea-beef.html

Friday, June 20, 2008

USDA TO KOREA AND THE WORLD, EAT THAT AND LIKE IT

http://usdavskorea.blogspot.com/2008/06/usda-to-korea-and-world-eat-that-and.html

Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted USA Beef

By Terry S. Singeltary Sr. May 15, 2008

Straight to the Source

Web Note: This is an important commentary by Terry S. Singeltary Sr., on a recent Business Week story on the controversy in South Korea over their government's lifting on the ban on conventional (non-organic) beef, despite the fact that the USDA is still allowing slaughterhouse waste and blood and manure to be fed to cows, and refusing to test all cows at slaughter. See the Mad Cow section of the OCA website for in-depth information. Terry is a regular blogger on the OCA website on Mad Cow issues.

Ronnie Cummins

One Korean official says the probability of a human being catching a mad cow disease by eating U.S. beef is like the one of a golf player scoring a hole-in-one and then being killed by lightning.

this is typical BSe. you here industry groups comment 'your more likely to get hit by a car than die from CJD'. well, maybe so, but my mother and many more did not die from getting hit by a car, they died from CJD, my mothers being the hvCJD (confirmed), and my neighbors mother died from CJD (confirmed). the UKBSEnvCJD _only_ theory is incorrect. there are more strains of mad cow than the UK BSE in beef to nvCJD in humans in the UK. The deception by the USDA, FDA, and the Bush administration about mad cow disease, CJD, and all Transmissible Spongiform Encephalopathy over the past 8 years have been outrageous, to a point of being criminal. I am vested in nothing, but the truth.

snip...see full text ;

http://www.grassrootsnetroots.org/articles/article_12387.cfm

Tuesday, May 13, 2008

Concerned Americans against Mad Cow Disease STATEMENT OF SOLIDARITY with Koreans May 13, 2008

http://usdavskorea.blogspot.com/2008/05/concerned-americans-against-mad-cow.html

Tuesday, May 13, 2008

Concerned Americans against Mad Cow Disease STATEMENT OF SOLIDARITY with Koreans May 13, 2008

snip...

Re..Korea vs USDA beef (the truth)

Greetings KIWA et al and all Koreans,

A kind greetings from Bacliff, Texas.

I submit this data with great concern, sincerity, and in peace.

President Lee Myung-bak states ;

Greetings KIWA et al and all Koreans,

A kind greetings from Bacliff, Texas.

I submit this data with great concern, sincerity, and in peace.

President Lee Myung-bak states ;

"halt imports if another case of bovine spongiform encephalopathy turned up in the United States." now that is funny. a mad cow with BSE would have to drop from the sky onto the white house lawn and run around jerking, trembling, stumbling and staggering uncontrollably for months before anyone would every confirm a mad cow case with BSE, and then it would take an act of congress to confirm it, and President Lee Myung-bak knows this. it's all about commodities and futures $$$

Monday, May 5, 2008

STATEMENT OF DR. RICHARD RAYMOND USDA UNDERSECRETARY FOR FOOD SAFETY Regarding the Safety of the U.S. Food Supply please see full text with some additional information the good Dr. Raymond seems to have forgotten about ;

http://usdameatexport.blogspot.com/2008/05/statement-of-dr-richard-raymond-usda.html

snip... full text ;

http://usdavskorea.blogspot.com/2008_12_01_archive.html

Kim Min-sun is correct about mad cow fears from USDA BEEF

Kim Min-sun, who allegedly "misled the public to boycott U.S. beef consumption", did NOT mislead anyone. the fact of the matter is, the Korean Government, and it's people, are being mislead by the USA government i.e. USDA. the proof is here, you only need to watch this video and you will see whom has mislead whom... SEE THE DAMNING VIDEO NOW AT THE BOTTOM OF THE BLOG BELOW ;

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

SOME FACTS AND UPDATED SCIENCE ON ALL STRAINS OF BSE TSE...TSS

Atypical BSE in Cattle

BSE has been linked to the human disease variant Creutzfeldt Jakob Disease (vCJD). The known exposure pathways for humans contracting vCJD are through the consumption of beef and beef products contaminated by the BSE agent and through blood transfusions. However, recent scientific evidence suggests that the BSE agent may play a role in the development of other forms of human prion diseases as well. These studies suggest that classical type of BSE may cause type 2 sporadic CJD and that H-type atypical BSE is connected with a familial form of CJD.

To date the OIE/WAHO assumes that the human and animal health standards set out in the BSE chapter for classical BSE (C-Type) applies to all forms of BSE which include the H-type and L-type atypical forms. This assumption is scientifically not completely justified and accumulating evidence suggests that this may in fact not be the case. Molecular characterization and the spatial distribution pattern of histopathologic lesions and immunohistochemistry (IHC) signals are used to identify and characterize atypical BSE. Both the L-type and H-type atypical cases display significant differences in the conformation and spatial accumulation of the disease associated prion protein (PrPSc) in brains of afflicted cattle. Transmission studies in bovine transgenic and wild type mouse models support that the atypical BSE types might be unique strains because they have different incubation times and lesion profiles when compared to C-type BSE. When L-type BSE was inoculated into ovine transgenic mice and Syrian hamster the resulting molecular fingerprint had changed, either in the first or a subsequent passage, from L-type into C-type BSE. In addition, non-human primates are specifically susceptible for atypical BSE as demonstrated by an approximately 50% shortened incubation time for L-type BSE as compared to C-type. Considering the current scientific information available, it cannot be assumed that these different BSE types pose the same human health risks as C-type BSE or that these risks are mitigated by the same protective measures.

snip...see full text ;

http://www.prionetcanada.ca/detail.aspx?menu=5&dt=293380&app=93&cat1=387&tp=20&lk=no&cat2

Thursday, August 12, 2010

Seven main threats for the future linked to prions

First threat

The TSE road map defining the evolution of European policy for protection against prion diseases is based on a certain numbers of hypotheses some of which may turn out to be erroneous. In particular, a form of BSE (called atypical Bovine Spongiform Encephalopathy), recently identified by systematic testing in aged cattle without clinical signs, may be the origin of classical BSE and thus potentially constitute a reservoir, which may be impossible to eradicate if a sporadic origin is confirmed.

***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.

Second threat

snip...

http://www.neuroprion.org/en/np-neuroprion.html

http://prionpathy.blogspot.com/2010/08/seven-main-threats-for-future-linked-to.html

http://prionpathy.blogspot.com/

Rural and Regional Affairs and Transport References Committee

The possible impacts and consequences for public health, trade and agriculture of the Government's decision to relax import restrictions on beef Final report June 2010

2.65 At its hearing on 14 May 2010, the committee heard evidence from Dr Alan Fahey who has recently submitted a thesis on the clinical neuropsychiatric, epidemiological and diagnostic features of Creutzfeldt-Jakob disease.48 Dr Fahey told the committee of his concerns regarding the lengthy incubation period for transmissible spongiform encephalopathies, the inadequacy of current tests and the limited nature of our current understanding of this group of diseases.49

2.66 Dr Fahey also told the committee that in the last two years a link has been established between forms of atypical CJD and atypical BSE. Dr Fahey said that: They now believe that those atypical BSEs overseas are in fact causing sporadic Creutzfeldt-Jakob disease. They were not sure if it was due to mad sheep disease or a different form. If you look in the textbooks it looks like this is just arising by itself. But in my research I have a summary of a document which states that there has never been any proof that sporadic Creutzfeldt-Jakob disease has arisen de novo-has arisen of itself. There is no proof of that. The recent research is that in fact it is due to atypical forms of mad cow disease which have been found across Europe, have been found in America and have been found in Asia. These atypical forms of mad cow disease typically have even longer incubation periods than the classical mad cow disease.50

http://www.aph.gov.au/senate/committee/rrat_ctte/mad_cows/report/report.pdf

The conclusions state that, at present, the only TSE agent demonstrated to be zoonotic is the classical BSE agent. Active screening has allowed the identification of 3 new forms of animal TSEs (H-type atypical BSE, L-type atypical BSE, and atypical scrapie), but the information obtained has major limitations due to the unknown sensitivity of the current monitoring system for these TSEs. There is no epidemiological evidence to suggest that classical scrapie is zoonotic. The epidemiological data are too limited to conclude whether the atypical scrapie agent has a zoonotic potential. Transmission experiments to human PrP transgenic mice or primates suggest that some TSE agents other than the classical BSE agent in cattle (namely L-type atypical BSE, classical BSE in sheep, TME, CWD agents) might have zoonotic potential and indicate that that of the L-type atypical BSE agent appears similar or even higher than that of the classical BSE agent. A single study reported efficient transmission of a natural sheep classical scrapie isolate to primates.

Commentary ---------- Following to a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) and the European Centre for Disease Prevention and Control (ECDC) were asked to deliver a scientific opinion on any possible epidemiological or molecular association between transmissible spongiform encephalopathies (TSEs) in animals and humans. The opinion reviews and discusses the existing scientific evidence that links animal and human TSEs currently known.

The opinion first considers the definition of zoonoses and the principles for the identification of zoonotic diseases, which can be based on evidence gathered from both epidemiological and laboratory studies. The opinion describes the challenges involved in identifying TSEs as zoonoses, due to the specific characteristics of TSE infections/diseases, such as the nature of TSE agents, the occurrence of animal and human TSEs, and the type of monitoring applied, the long incubation period of TSEs etc. The example of the process that led to establishing a link between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) is reviewed. The epidemiological and laboratory criteria that can be used to investigate such a link are described in detail, since those criteria might be useful for the identification of links between other animal and human TSEs.

The opinion discusses the strain diversity of the TSE agents described in sheep, goats, cattle, cervids, and humans, based on the current knowledge, which highlights that multiple TSE agents exist in each species. The factors influencing the capacity of TSE agents to cross the species transmission barrier are then considered in detail, including the variability in host and donor PrP gene and protein, the TSE strain type involved and its interaction with the host PrP, and the route of infection.

The opinion critically assesses the tools and methodologies currently available to study and evaluate the possible association between animal and human TSEs. The use of epidemiology is discussed for TSEs in both animals and humans, and the possibility to compare the 2 sources of information is presented as a possible method to study the possible links.

Both in vivo and in vitro laboratory methods are considered and discussed, including neuropathology, transmission experiments involving different animal models (wild type and transgenic mice, primates and other species), biochemical methods, cell-free conversion assays, protein misfolding cyclic amplification (PMCA), and cell culture assays. Characteristics, advantages, and disadvantages of the different methods are reviewed, including the opportunity to collate data from different types of experiments for the study of potential associations between animal and human TSEs.

The opinion then reviews the scientific evidence currently available for the different animal and human TSEs, including classical BSE, atypical BSE (H-type and L-type), classical scrapie, atypical scrapie, chronic wasting disease (CWD), transmissible mink encephalopathy (TME), and human TSEs. In particular, the following aspects are systematically discussed for each TSE agent: epidemiology, pathogenesis, and in vivo and in vitro transmission experiments.

The opinion concludes that, at present, the only TSE agent demonstrated to be zoonotic is the classical BSE agent. With regard to human TSEs, detected cases of sporadic CJD are randomly distributed in time and geographical location. These observations have been interpreted as a supportive argument that sporadic CJD is not environmentally acquired. However, the epidemiological evidence in relation to sporadic CJD cannot be regarded as definitive, and the possibility that a small proportion of cases are zoonotic cannot be excluded.

It also concludes that a series of uncertainties in relation to the epidemiological patterns of animal and human TSEs indicate that even a rough comparison of the present epidemiological patterns of human and animal TSEs other than classical BSE is unlikely to be informative. Because of these uncertainties, it is an imperative to continue to carry out systematic surveillance of human TSE diseases, and to continue and improve the surveillance of animal TSE diseases.

The opinion highlights that the active screening has allowed the identification of 3 new forms of animal TSEs (L-type atypical BSE, H-type atypical BSE, and atypical scrapie), but that the information obtained has major limitations due to the unknown sensitivity of the current monitoring system for these TSEs.

There is no epidemiological evidence to suggest that classical scrapie is zoonotic. The epidemiological data are too limited to conclude whether the atypical scrapie agent has a zoonotic potential.

Transmission experiments to human PrP transgenic mice suggest that some TSE agents other than the classical BSE agent in cattle (namely L-type atypical BSE and classical BSE in sheep agents) might have zoonotic potential, whereas for other agents there is no evidence provided of a zoonotic potential (H-type atypical BSE and CWD), or no published studies are available (classical and atypical scrapie). In addition, transmission experiments to primates suggest that some TSE agents other than the classical BSE agent in cattle (namely L-type atypical BSE, classical BSE in sheep, TME, CWD agents) might have zoonotic potential. In particular, primates are highly permissive to L-type atypical BSE, even by the oral route.

The opinion emphasizes that laboratory transmission experiments indicate that the L-type atypical BSE agent has a significant zoonotic potential, which appears similar or even higher than that of the classical BSE agent. While transmission data for evaluating the zoonotic potential of classical scrapie in primates and human PrP transgenic mice are extremely limited or not yet available, a single study reported efficient transmission of a natural sheep classical scrapie isolate to primates.

The opinion concludes that human PrP transgenic mice and primates are currently the most relevant models for investigating the human transmission barrier, but the extent to which such models are informative for measuring the zoonotic potential of an animal TSE under field exposure conditions is unknown. It is unpredictable whether a TSE agent will transmit to a new host, and if the transmission principally occurs, what the transmission rate will be.

Based on the results obtained with in vitro conversion assays, the opinion concludes that there is probably no absolute molecular barrier to transmission of TSE agents between mammalian species. Results also suggest that these assays may be developed as a tool for quantifying the transmission barriers between species for different TSE agent strains; however, there is no means at the moment to transpose in vitro results into the likelihood of in vivo interspecies transmission.

-- Communicated by: Terry S Singeltary Sr

[ProMED-mail thanks Terry S Singeltary Sr for drawing attention to this comprehensive document which provides a current evaluation of experimental work designed to explore the zoonotic potential of the various recently recognised TSEs of domestic and other animals.

It is concluded that at present the only TSE agent demonstrated to be zoonotic is the classical BSE agent. Nor can it be entirely excluded at the present time that a small proportion of cases of sporadic CJD may be environmentally acquired. - Mod.CP]

******

http://www.promedmail.org/pls/apex/f?p=2400:1202:888892554804923::NO::F2400_P1202_CHECK_DISPLAY,F2400_P1202_PUB_MAIL_ID:X,88784

[Terry S. Singeltary Sr. has added the following comment:

"According to the World Health Organisation, the future public health threat of vCJD in the UK and Europe and potentially the rest of the world is of concern and currently unquantifiable. However, the possibility of a significant and geographically diverse vCJD epidemic occurring over the next few decades cannot be dismissed

http://whqlibdoc.who.int/publications/2003/9241545887.pdf

http://www.promedmail.org/pls/apex/f?p=2400:1001:568933508083034::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,82101

14th ICID International Scientific Exchange Brochure -

Final Abstract Number: ISE.114

Session: International Scientific Exchange

Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009

T. Singeltary

Bacliff, TX, USA

Background:

An update on atypical BSE and other TSE in North America. Please remember, the typical U.K. c-BSE, the atypical l-BSE (BASE), and h-BSE have all been documented in North America, along with the typical scrapie's, and atypical Nor-98 Scrapie, and to date, 2 different strains of CWD, and also TME. All these TSE in different species have been rendered and fed to food producing animals for humans and animals in North America (TSE in cats and dogs ?), and that the trading of these TSEs via animals and products via the USA and Canada has been immense over the years, decades.

Methods:

12 years independent research of available data

Results:

I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2009. With all the science to date refuting it, to continue to validate this old myth, will only spread this TSE agent through a multitude of potential routes and sources i.e. consumption, medical i.e., surgical, blood, dental, endoscopy, optical, nutritional supplements, cosmetics etc.

Conclusion:

I would like to submit a review of past CJD surveillance in the USA, and the urgent need to make all human TSE in the USA a reportable disease, in every state, of every age group, and to make this mandatory immediately without further delay. The ramifications of not doing so will only allow this agent to spread further in the medical, dental, surgical arena's. Restricting the reporting of CJD and or any human TSE is NOT scientific. Iatrogenic CJD knows NO age group, TSE knows no boundaries. I propose as with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE Transmissible Spongiform Encephalopathy is far from an exact science, but there is enough proven science to date that this myth should be put to rest once and for all, and that we move forward with a new classification for human and animal TSE that would properly identify the infected species, the source species, and then the route.

page 114 ;

http://ww2.isid.org/Downloads/14th_ICID_ISE_Abstracts.pdf

Saturday, July 23, 2011

CATTLE HEADS WITH TONSILS, BEEF TONGUES, SPINAL CORD, SPECIFIED RISK MATERIALS (SRM's) AND PRIONS, AKA MAD COW DISEASE

http://transmissiblespongiformencephalopathy.blogspot.com/2011/07/cattle-heads-with-tonsils-beef-tongues.html

Saturday, November 6, 2010

TAFS1 Position Paper on Position Paper on Relaxation of the Feed Ban in the EU Berne, 2010 TAFS

INTERNATIONAL FORUM FOR TRANSMISSIBLE ANIMAL DISEASES AND FOOD SAFETY a non-profit Swiss Foundation

http://madcowfeed.blogspot.com/2010/11/tafs1-position-paper-on-position-paper.html

Archive Number 20101206.4364 Published Date 06-DEC-2010 Subject PRO/AH/EDR> Prion disease update 2010 (11)

PRION DISEASE UPDATE 2010 (11)

http://www.promedmail.org/pls/apex/f?p=2400:1001:5492868805159684::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,86129

Saturday, March 5, 2011

MAD COW ATYPICAL CJD PRION TSE CASES WITH CLASSIFICATIONS PENDING ON THE RISE IN NORTH AMERICA

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/mad-cow-atypical-cjd-prion-tse-cases.html

Sunday, August 21, 2011

The British disease, or a disease gone global, The TSE Prion Disease

snip...

CANADA CJD UPDATE 2011

CJD Deaths Reported by CJDSS1, 1994-20112 As of January 31, 2011

3. Final classification of 49 cases from 2009, 2010, 2011 is pending.

snip...

http://www.phac-aspc.gc.ca/hcai-iamss/cjd-mcj/cjdss-ssmcj/pdf/stats_0111-eng.pdf

USA 2011

USA

National Prion Disease Pathology Surveillance Center

Cases Examined1

(November 1, 2010)

Year Total Referrals2 Prion Disease Sporadic Familial Iatrogenic vCJD

1996 earlier 51 33 28 5 0 0

1997 114 68 59 9 0 0

1998 87 51 43 7 1 0

1999 121 73 65 8 0 0

2000 146 103 89 14 0 0

2001 209 119 109 10 0 0

2002 248 149 125 22 2 0

2003 274 176 137 39 0 0

2004 325 186 164 21 0 13

2005 344 194 157 36 1 0

2006 383 197 166 29 0 24

2007 377 214 187 27 0 0

2008 394 231 205 25 0 0

2009 425 258 215 43 0 0

2010 333 213 158 33 0 0

TOTAL 38315 22656 1907 328 4 3

1 Listed based on the year of death or, if not available, on year of referral;

2 Cases with suspected prion disease for which brain tissue and/or blood (in familial cases) were submitted;

3 Disease acquired in the United Kingdom;

4 Disease was acquired in the United Kingdom in one case and in Saudi Arabia in the other case;

5 Includes 18 cases in which the diagnosis is pending, and 18 inconclusive cases;

6 Includes 23 (22 from 2010) cases with type determination pending in which the diagnosis of vCJD has been excluded.

http://www.cjdsurveillance.com/pdf/case-table.pdf

Please notice where sporadic CJD cases in 1996 went from 28 cases, to 215 cases in 2009, the highest recorded year to date.

sporadic CJD is on a steady rise, and has been since 1996.

I also urge you to again notice these disturbing factors in lines 5 and 6 ;

5 Includes 18 cases in which the diagnosis is pending, and 18 inconclusive cases;

6 Includes 23 (22 from 2010) cases with type determination pending in which the diagnosis of vCJD has been excluded.

========end=====tss=====2011

snip...SEE FULL TEXT WITH VIDEOS ;

Sunday, August 21, 2011

The British disease, or a disease gone global, The TSE Prion Disease

http://transmissiblespongiformencephalopathy.blogspot.com/2011/08/british-disease-or-disease-gone-global.html

Thursday, August 4, 2011

Terry Singeltary Sr. on the Creutzfeldt-Jakob Disease Public Health Crisis, Date aired: 27 Jun 2011

(see video here) ;

http://transmissiblespongiformencephalopathy.blogspot.com/2011/08/terry-singeltary-sr-on-creutzfeldt.html

Sunday, August 21, 2011

The British disease, or a disease gone global, The TSE Prion Disease

(see video here)

http://transmissiblespongiformencephalopathy.blogspot.com/2011/08/british-disease-or-disease-gone-global.html

Thursday, July 08, 2010

GLOBAL CLUSTERS OF CREUTZFELDT JAKOB DISEASE - A REVIEW 2010

http://creutzfeldt-jakob-disease.blogspot.com/2010/07/global-clusters-of-creutzfeldt-jakob.html

Friday, June 17, 2011

Treatable neurological disorders misdiagnosed as Creutzfeldt-Jakob disease

http://creutzfeldt-jakob-disease.blogspot.com/2011/06/treatable-neurological-disorders.html

Friday, November 30, 2007

CJD QUESTIONNAIRE USA CWRU AND CJD FOUNDATION

http://cjdquestionnaire.blogspot.com/2007/11/cjd-questionnaire.html

http://cjdquestionnaire.blogspot.com/

Wednesday, August 24, 2011

There Is No Safe Dose of Prions

http://transmissiblespongiformencephalopathy.blogspot.com/2011/08/there-is-no-safe-dose-of-prions.html

Wednesday, August 24, 2011

All Clinically-Relevant Blood Components Transmit Prion Disease following a Single Blood Transfusion: A Sheep Model of vCJD

http://transmissiblespongiformencephalopathy.blogspot.com/2011/08/all-clinically-relevant-blood.html

Wednesday, June 29, 2011

TSEAC Meeting August 1, 2011 donor deferral Saudi Arabia vCJD risk blood and blood products

http://tseac.blogspot.com/2011/06/tseac-meeting-august-1-2011-donor.html

Monday, May 23, 2011

Atypical Prion Diseases in Humans and Animals 2011

Top Curr Chem (2011)

DOI: 10.1007/128_2011_161

# Springer-Verlag Berlin Heidelberg 2011

Michael A. Tranulis, Sylvie L. Benestad, Thierry Baron, and Hans Kretzschmar

http://bse-atypical.blogspot.com/2011/05/atypical-prion-diseases-in-humans-and.html

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518

The Honorable Ms. Kim Min-sun Anti-US Beef Actress Prevails in Court

2010-02-10T08:06:00.000-08:00

Sent: Tuesday, February 09, 2010 4:59 PM
Subject: Kim Min-sun Anti-US Beef Actress Prevails in Court

02-09-2010 19:38

Anti-US Beef Actress Prevails in Court

By Park Si-soo Staff Reporter

Actress Kim Min-sun won a legal battle Tuesday, started by an American beef importer for an article she wrote two years ago on her private blog that allegedly exaggerated the risk of mad cow disease associated with U.S. beef.

In May 2008, when the country was trapped in heated debate over the resumption of U.S. beef imports and its association with mad cow disease, the actress said in the article, "I would gulp a cup of potassium cyanide rather than eat a piece of American beef infected with the disease."

As the comment drew media attention, an American beef importer in Seoul, A-Meat, filed a suit against the actress and five staff members of an investigative TV journal, PD Notebook, for interrupting its business by spreading what it called "groundless" information about the imported beef. The importer also claimed its bottom line was hit hard by her defamatory article.

But the Seoul Southern District Court Tuesday ruled the actress and the TV program were not liable for any damages to the importer.

Judge Kim Sung-gon said in the ruling, "Her article revealed no specific information associated with the plaintiff. So it cannot be seen that her article interrupted its business." The judge also acquitted the five TV producers, saying the program was wholly based on data they compiled in the belief that they were all scientifically grounded.

"Also, the program was to criticize the government for a deal with Washington allegedly endorsed in a cursory manner, not a specific company," the judge said.

Two years have passed since the social unrest, provoked by the resumption of U.S. beef imports without thorough restrictions to keep risky parts of American beef at bay, ended.

To quell enraged citizens, who took to major streets for three months, President Lee Myung-bak solicited for the U.S. government to modify the terms of the contract signed between the two parties, made public apologies and reshuffled the Cabinet.

But society is still divided and shows no immediate sign of mending the rift. Rather, what is left over from the unrest is still plaguing the administration by providing a ground for ideological showdowns between those in favor of the conservative administration and its opponents, levying a heavy political burden on President Lee, who is in the midst of his five-year presidency.

The latest controversy, associated with the beef scandal two years ago, resurfaced after a court ruling early this month that exonerated the five TV producers from defamation charges.

On Jan. 20, the Seoul Central District Court cleared them on defamation charges for allegedly wrongly portraying the actions of two senior state trade negotiators during the Seoul-Washington talks to resume U.S. beef imports in 2008.

The ruling provoked immediate condemnation from conservative activists and politicians, pressuring the head of the judiciary to step down, calling the verdict a decision based on ideological bias. Some overzealous activists even staged rallies in front of the home of the judge in charge of the case, calling for his resignation.

Liberal activists and politicians condemned their moves, describing a series of acts by their counterparts as politically motivated moves to sway the judiciary, whose independent operation is guaranteed under the Constitution.

Galvanized by the ruling, the ruling Grand National Party is now pushing a package of bills to tighten its grip on the judiciary, while opposition parties are trying to strike down the attempt.

pss@koreatimes.co.kr

flounder Del (71.248.137.150) 02-10-2010 07:39

To Honorable Ms. Kim Min-Sun and Korea,

The Truth will set us free.

Thank You Ma'am ! You are very courageous ! Your Country-man and Country-Woman should be proud. ...TSS

http://www.koreatimes.co.kr/www/news/nation/2010/02/113_60573.html

Wednesday, January 13, 2010

High Court Rules In Favor of PD Notebook 01-13-2010 21:21

http://usdavskorea.blogspot.com/2010/01/high-court-rules-in-favor-of-pd.html

Saturday, August 22, 2009

FREE Kim Min-sun, she is correct about mad cow fears from USDA BEEF

http://usdavskorea.blogspot.com/2009/08/free-kim-min-sun-she-is-correct-about.html

http://bse-atypical.blogspot.com/2010/01/14th-international-congress-on.html

Saturday, August 22, 2009

FREE Kim Min-sun, she is correct about mad cow fears from USDA BEEF

http://usdavskorea.blogspot.com/2009/08/free-kim-min-sun-she-is-correct-about.html

Sent: Friday, January 29, 2010 3:23 PM

Subject: 14th International Congress on Infectious Diseases H-type and L-type Atypical BSE January 2010 (special pre-congress edition)

18.173 page 189

Experimental Challenge of Cattle with H-type and L-type Atypical BSE

A. Buschmann1, U. Ziegler1, M. Keller1, R. Rogers2, B. Hills3, M.H. Groschup1. 1Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany, 2Health Canada, Bureau of Microbial Hazards, Health Products & Food Branch, Ottawa, Canada, 3Health Canada, Transmissible Spongiform Encephalopathy Secretariat, Ottawa, Canada

Background: After the detection of two novel BSE forms designated H-type and L-type atypical BSE the question of the pathogenesis and the agent distribution of these two types in cattle was fully open. From initial studies of the brain pathology, it was already known that the anatomical distribution of L-type BSE differs from that of the classical type where the obex region in the brainstem always displays the highest PrPSc concentrations. In contrast in L-type BSE cases, the thalamus and frontal cortex regions showed the highest levels of the pathological prion protein, while the obex region was only weakly involved.

Methods:We performed intracranial inoculations of cattle (five and six per group) using 10%brainstemhomogenates of the two German H- and L-type atypical BSE isolates. The animals were inoculated under narcosis and then kept in a free-ranging stable under appropriate biosafety conditions.At least one animal per group was killed and sectioned in the preclinical stage and the remaining animals were kept until they developed clinical symptoms. The animals were examined for behavioural changes every four weeks throughout the experiment following a protocol that had been established during earlier BSE pathogenesis studies with classical BSE.

Results and Discussion: All animals of both groups developed clinical symptoms and had to be euthanized within 16 months. The clinical picture differed from that of classical BSE, as the earliest signs of illness were loss of body weight and depression. However, the animals later developed hind limb ataxia and hyperesthesia predominantly and the head. Analysis of brain samples from these animals confirmed the BSE infection and the atypical Western blot profile was maintained in all animals. Samples from these animals are now being examined in order to be able to describe the pathogenesis and agent distribution for these novel BSE types. Conclusions: A pilot study using a commercially avaialble BSE rapid test ELISA revealed an essential restriction of PrPSc to the central nervous system for both atypical BSE forms. A much more detailed analysis for PrPSc and infectivity is still ongoing.

http://www.isid.org/14th_icid/

http://ww2.isid.org/Downloads/IMED2009_AbstrAuth.pdf

http://www.isid.org/publications/ICID_Archive.shtml

From: xxxx
To: Terry Singeltary
Sent: Saturday, December 05, 2009 9:09 AM
Subject: 14th ICID - abstract accepted for 'International Scientific Exchange'

Your preliminary abstract number: 670

Dear Mr. Singeltary,

On behalf of the Scientific Committee, I am pleased to inform you that your abstract

'Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009'

WAS accepted for inclusion in the INTERNATIONAL SCIENTIFIC EXCHANGE (ISE) section of the 14th International Congress on Infectious Diseases. Accordingly, your abstract will be included in the "Intl. Scientific Exchange abstract CD-rom" of the Congress which will be distributed to all participants.

Abstracts accepted for INTERNATIONAL SCIENTIFIC EXCHANGE are NOT PRESENTED in the oral OR poster sessions.

Your abstract below was accepted for: INTERNATIONAL SCIENTIFIC EXCHANGE

#0670: Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009

Author: T. Singeltary; Bacliff, TX/US

Topic: Emerging Infectious Diseases Preferred type of presentation: International Scientific Exchange

This abstract has been ACCEPTED.

#0670: Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009

Authors: T. Singeltary; Bacliff, TX/US

Title: Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009

Body: Background

An update on atypical BSE and other TSE in North America. Please remember, the typical U.K. c-BSE, the atypical l-BSE (BASE), and h-BSE have all been documented in North America, along with the typical scrapie's, and atypical Nor-98 Scrapie, and to date, 2 different strains of CWD, and also TME. All these TSE in different species have been rendered and feed to food producing animals for humans and animals in North America (TSE in cats and dogs ?), and that the trading of these TSEs via animals and products via the USA and Canada has been immense over the years, decades.

Methods

12 years independent research of available data

Results

I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2009. With all the science to date refuting it, to continue to validate this old myth, will only spread this TSE agent through a multitude of potential routes and sources i.e. consumption, medical i.e., surgical, blood, dental, endoscopy, optical, nutritional supplements, cosmetics etc.

Conclusion

I would like to submit a review of past CJD surveillance in the USA, and the urgent need to make all human TSE in the USA a reportable disease, in every state, of every age group, and to make this mandatory immediately without further delay. The ramifications of not doing so will only allow this agent to spread further in the medical, dental, surgical arena's. Restricting the reporting of CJD and or any human TSE is NOT scientific. Iatrogenic CJD knows NO age group, TSE knows no boundaries.

I propose as with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE Transmissible Spongiform Encephalopathy is far from an exact science, but there is enough proven science to date that this myth should be put to rest once and for all, and that we move forward with a new classification for human and animal TSE that would properly identify the infected species, the source species, and then the route.

Keywords: Transmissible Spongiform Encephalopathy Creutzfeldt Jakob Disease Prion

http://www.isid.org/14th_icid/

http://www.isid.org/publications/ICID_Archive.shtml

http://ww2.isid.org/Downloads/IMED2009_AbstrAuth.pdf

Monday, October 19, 2009

Atypical BSE, BSE, and other human and animal TSE in North America Update October 19, 2009

snip...

I ask Professor Kong ;

Thursday, December 04, 2008 3:37 PM Subject: RE: re--Chronic Wating Disease (CWD) and Bovine Spongiform Encephalopathies (BSE): Public Health Risk Assessment

''IS the h-BSE more virulent than typical BSE as well, or the same as cBSE, or less virulent than cBSE? just curious.....''

Professor Kong reply ;

.....snip

''As to the H-BSE, we do not have sufficient data to say one way or another, but we have found that H-BSE can infect humans. I hope we could publish these data once the study is complete.

Thanks for your interest.''

Best regards,

Qingzhong Kong, PhD Associate Professor Department of Pathology Case Western Reserve University Cleveland, OH 44106 USA

END...TSS

I look forward to further transmission studies, and a true ENHANCED BSE/atypical BSE surveillance program put forth testing all cattle for human and animal consumption for 5 years. a surveillance program that uses the most sensitive TSE testing, and has the personnel that knows how to use them, and can be trusted. I look forward to a stringent mad cow feed ban being put forth, and then strictly enforced. we need a forced, not voluntary feed ban, an enhanced feed ban at that, especially excluding blood. we need some sort of animal traceability. no more excuses about privacy. if somebody is putting out a product that is killing folks and or has the potential to kill you, then everybody needs to know who they are, and where that product came from. same with hospitals, i think medical incidents in all states should be recorded, and made public, when it comes to something like a potential accidental transmission exposure event. so if someone is out there looking at a place to go have surgery done, if you have several hospitals having these type 'accidental exposure events', than you can go some place else. it only makes sense. somewhere along the road, the consumer lost control, and just had to take whatever they were given, and then charged these astronomical prices. some where along the line the consumer just lost interest, especially on a long incubating disease such as mad cow disease i.e. Transmissible Spongiform Encephalopathy. like i said before, there is much more to the mad cow story than bovines and eating a hamburger, we must start focusing on all TSE in all species. ...TSS

http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html

snip... see full text ;

Friday, January 29, 2010

14th International Congress on Infectious Diseases H-type and L-type Atypical BSE January 2010 (special pre-congress edition)

http://bse-atypical.blogspot.com/2010/01/14th-international-congress-on.html

Thursday, February 4, 2010

SPONGIFORM ENCEPHALOPATHY ADVISORY COMMITTEE Draft Minutes of the 103rd Meeting held on 24th November 2009

http://seac992007.blogspot.com/2010/02/spongiform-encephalopathy-advisory.html

Friday, February 05, 2010

New Variant Creutzfelt Jakob Disease case reports United States 2010 A Review

http://vcjd.blogspot.com/2010/02/new-variant-creutzfelt-jakob-disease.html

past history ;

U.S. slams door on revising S. Korea beef import pact

June 11, 2008, 10:14PM

http://usdavskorea.blogspot.com/2008/06/us-slams-door-on-revising-s-korea-beef.html

Wednesday, June 11, 2008

OIE Recognition of the BSE Status of Members RESOLUTION No. XXI (Adopted by the International Committee of the OIE on 27 May 2008)

http://usdavskorea.blogspot.com/2008/06/oie-recognition-of-bse-status-of.html

Saturday, June 7, 2008

Export Requirements for the Republic of Korea IMPORT HEALTH REQUIREMENTS FOR U.S. BEEF AND BEEF PRODUCTS

http://usdavskorea.blogspot.com/2008/06/export-requirements-for-republic-of.html

Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted USA Beef

By Terry S. Singeltary Sr. May 15, 2008

Straight to the Source

Web Note: This is an important commentary by Terry S. Singeltary Sr., on a recent Business Week story on the controversy in South Korea over their government's lifting on the ban on conventional (non-organic) beef, despite the fact that the USDA is still allowing slaughterhouse waste and blood and manure to be fed to cows, and refusing to test all cows at slaughter. See the Mad Cow section of the OCA website for in-depth information. Terry is a regular blogger on the OCA website on Mad Cow issues.

Ronnie Cummins

One Korean official says the probability of a human being catching a mad cow disease by eating U.S. beef is like the one of a golf player scoring a hole-in-one and then being killed by lightning.

this is typical BSe. you here industry groups comment 'your more likely to get hit by a car than die from CJD'. well, maybe so, but my mother and many more did not die from getting hit by a car, they died from CJD, my mothers being the hvCJD (confirmed), and my neighbors mother died from CJD (confirmed). the UKBSEnvCJD _only_ theory is incorrect. there are more strains of mad cow than the UK BSE in beef to nvCJD in humans in the UK. The deception by the USDA, FDA, and the Bush administration about mad cow disease, CJD, and all Transmissible Spongiform Encephalopathy over the past 8 years have been outrageous, to a point of being criminal. I am vested in nothing, but the truth.

snip...see full text ;

http://www.grassrootsnetroots.org/articles/article_12387.cfm

Tuesday, May 13, 2008

Concerned Americans against Mad Cow Disease STATEMENT OF SOLIDARITY with Koreans May 13, 2008

http://usdavskorea.blogspot.com/2008/05/concerned-americans-against-mad-cow.html

Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

High Court Rules In Favor of PD Notebook

2010-01-13T14:04:00.000-08:00

01-13-2010 21:21

High Court Rules In Favor of PD Notebook

A high court ruled in favor of MBC TV's PD Notebook, Wednesday, in an appeal filed by 462 people who demanded compensation for psychological damage caused by the program's alleged distorted reporting on U.S. beef.

In September, 2008, 2,455 people filed a class action against MBC, the program directors and writers, demanding 2.5 billion won ($1.7 million) in compensation. However, only 462 appealed a lower court ruling.

The Seoul High Court said, "There is no explicit evidence that the program worked as a direct trigger for candlelit protests against the government. Neither is there causality between the program and damage claimed by the plaintiffs."

Still, it upheld the lower court ruling that information in the program may have been "partially inaccurate."

In April 2008, an episode of the program suggested that people who consume U.S. beef could contract the human form of "mad cow disease." The content enraged numerous citizens upset with a decision to resume American beef imports, resulting in tens of thousands of people taking to the streets of downtown Seou.l. calling for it to be reversed.

http://www.koreatimes.co.kr/www/news/nation/2010/01/117_58992.html

> Still, it upheld the lower court ruling that information in the program may have been "partially inaccurate." <

PLEASE show me what was inaccurate ? THE USA HAS DOCUMENTED MAD COW DISEASE, IT IS DOCUMENTED THAT THE USA HAS TRIED TO COVER-UP MAD COW DISEASE, AND FAILED, AND CJD IN THE USA IS RISING. THE USA REFUSES TO TEST TO FIND MAD COW DISEASE. U.S.A. HIDING MAD COW DISEASE VICTIMS AS SPORADIC CJD so what is inacurate ?

UPDATE March 28, 2010 ;

Joint Fact-Finding Mission to South Korea Final Report Seoul, South Korea July 21–24, 2008

http://material.ahrchk.net/docs/AHRC-SPR-006-2008-SouthKorea.pdf

http://minbyun.org/?module=file&act=procFileDownload&file_srl=27364&sid=0b0c8d8b3089eef17f3ae37d0d8538d2

however, i can tell you that it was the media and the womans doctor here in the USA that first reported she had human form of mad cow disease. and that's what PD NOTEBOOK and many other media outlets published, until the USDA (?) which first announced that it was not nvCJD. ... Portsmouth woman did not die of mad cow-related condition, ___USDA___ says

By Nancy Young The Virginian-Pilot © May 7, 2008

Preliminary test results indicate that a 22-year-old Portsmouth woman who died in April did not have an illness that has been associated with eating contaminated beef, a U.S. Department of Agriculture official said this week. "The epidemiologic characteristics of the illness and preliminary results of the neuropathologic testing of brain tissue obtained at autopsy indicate that the patient did not die of" a variant of Creutzfeldt-Jakob Disease (vCJD), which has been associated with mad cow disease, said Richard Raymond, USDA undersecretary for food safety. He was speaking Sunday to a group of Korean and American reporters in Washington. "The U.S. Centers for Disease Control and Prevention has just provided us with that information, and I felt it was important to share with you today," he told the group. The comment appears on a statement on the safety of the U.S. beef supply that is available on the USDA's Food Safety and Inspection Service Web site. Aretha Vinson died April 9 at Bon Secours Maryview Medical Center in Portsmouth. She had a degenerative brain condition that can be caused by a wide variety of things, and concerns were raised that she might have had vCJD. The state health department, CDC and the University of Virginia were involved in testing to determine the cause of death and whether it indicated a public health concern. "There's no threat to the general public," said Michelle Peregoy, a Virginia Department of Health spokeswoman. She would not say more, citing patient confidentiality issues. Nancy Young, (757) 446-2947, nancy.young@pilotonline.com

http://hamptonroads.com/2008/05/portsmouth-woman-did-not-die-mad-cowrelated-condition-usda-says

Virginia State University student Aretha Vinson has contracted a rare brain disorder called Creutzfeldt-Jakob Disease, a variant of Mad Cow Disease. Virginia state health officials are investigating how Vinson contracted the disease. Doctors suspect Vinson contracted the disease after having gastric bypass surgery, possibly from tainted medical instruments. Vinson's family says her health worsened after having gastric bypass surgery three months prior to the diagnosis. UPDATE: Vinson passed away at 5:30pm on Wednesday, April 9, 2008.

http://www.mahalo.com/stub/aretha-vinson

The program, which now faces charges for playing up the possibility that the woman died of vCJD, said, “The CDC last Thursday announced the cause of death of Aretha Vinson, who died of symptoms similar to vCJD.” It quoted the CDC as saying although the suspected case received international media attention, the National Prion Disease Pathology Surveillance Center determined that the cause of death was not due to vCJD, a finding, it pointed out, that was similar to an announcement by the Department of Agriculture.

http://english.chosun.com/w21data/html/news/200806/200806170006.html

22 year old sporadic CJD ???

we will never know ; In a telephone interview with the Chosun Ilbo, CDC spokesman Dave Daigle on Monday said the centers posted the announcement after performing their own checkup once the NPDPSC finished its investigation. He added that because the CDC only provide information on diseases, they have no plans to make a separate press release on the issue including the result of the investigation. ...

http://english.chosun.com/w21data/html/news/200806/200806170006.html

now, the cdc et al usually hide behind patient confidentiality to hide cjd cases. but in this 22 years old, confidentiality was not the case, she was well known around the world, and the cdc et al chose to hide her final diagnosis. why, because it was another young victim in the USA with sporadic CJD ???

SEE FULL TEXT ;

Tuesday, June 17, 2008

Portsmouth woman did not die of mad cow-related condition, USDA says

UPDATE Updated Jun.17, 2008 08:34 KST

http://cjdmadcowbaseoct2007.blogspot.com/2008/06/portsmouth-woman-did-not-die-of-mad-cow.html

Monday, October 19, 2009

Atypical BSE, BSE, and other human and animal TSE in North America Update October 19, 2009

http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html

Sunday, September 6, 2009

MAD COW USA 1997 SECRET VIDEO

http://madcowusda.blogspot.com/2009/09/mad-cow-usa-1997-video.html

U.S.A. HIDING MAD COW DISEASE VICTIMS AS SPORADIC CJD ? see video at bottom

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON PRIONS SPEAKING ABOUT ANN VENEMAN see video

http://maddeer.org/video/embedded/prusinerclip.html

14th ICID International Scientific Exchange Brochure -

Final Abstract Number: ISE.114

Session: International Scientific Exchange

Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America update October 2009

T. Singeltary Bacliff, TX, USA

Background: An update on atypical BSE and other TSE in North America. Please remember, the typical U.K. c-BSE, the atypical l-BSE (BASE), and h-BSE have all been documented in North America, along with the typical scrapie's, and atypical Nor-98 Scrapie, and to date, 2 different strains of CWD, and also TME. All these TSE in different species have been rendered and fed to food producing animals for humans and animals in North America (TSE in cats and dogs ?), and that the trading of these TSEs via animals and products via the USA and Canada has been immense over the years, decades.

Methods: 12 years independent research of available data

Results: I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2009. With all the science to date refuting it, to continue to validate this old myth, will only spread this TSE agent through a multitude of potential routes and sources i.e. consumption, medical i.e., surgical, blood, dental, endoscopy, optical, nutritional supplements, cosmetics etc.

Conclusion: I would like to submit a review of past CJD surveillance in the USA, and the urgent need to make all human TSE in the USA a reportable disease, in every state, of every age group, and to make this mandatory immediately without further delay. The ramifications of not doing so will only allow this agent to spread further in the medical, dental, surgical arena's. Restricting the reporting of CJD and or any human TSE is NOT scientific. Iatrogenic CJD knows NO age group, TSE knows no boundaries. I propose as with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE Transmissible Spongiform Encephalopathy is far from an exact science, but there is enough proven science to date that this myth should be put to rest once and for all, and that we move forward with a new classification for human and animal TSE that would properly identify the infected species, the source species, and then the route.

http://ww2.isid.org/Downloads/14th_ICID_ISE_Abstracts.pdf

International Society for Infectious Diseases Web:

http://www.isid.org

Saturday, January 2, 2010

Human Prion Diseases in the United States January 1, 2010 ***FINAL***

http://prionunitusaupdate2008.blogspot.com/2010/01/human-prion-diseases-in-united-states.html

my comments to PLosone here ;

http://www.plosone.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd&root=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd

Friday, February 05, 2010

New Variant Creutzfelt Jakob Disease case reports United States 2010 A Review

http://vcjd.blogspot.com/2010/02/new-variant-creutzfelt-jakob-disease.html

Sunday, February 14, 2010
[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine Spongiform Encephalopathy (BSE)

http://bseusa.blogspot.com/2010/02/docket-no-fsis-2006-0011-fsis-harvard.html

Wednesday, February 24, 2010

Transmissible Spongiform encephalopathy (TSE) animal and human TSE in North America 14th ICID International Scientific Exchange Brochure -

http://transmissiblespongiformencephalopathy.blogspot.com/2010/02/transmissible-spongiform-encephalopathy.html

TSE

http://transmissiblespongiformencephalopathy.blogspot.com/

Tuesday, March 16, 2010 COMMONWEALTH OF AUSTRALIA Hansard

Import restrictions on beef

FRIDAY, 5 FEBRUARY 2010 AUSTRALIA COMMONWEALTH OF AUSTRALIA Proof Committee Hansard

snip...see full text 110 pages ;

http://www.aph.gov.au/hansard/senate/commttee/S12742.pdf

for those interested, please see much more here ;

http://docket-aphis-2006-0041.blogspot.com/2010/03/commonwealth-of-australia-hansard.html

USA MAD COW FEED IN COMMERCE

http://madcowfeed.blogspot.com/

Wednesday, February 10, 2010 The Honorable Ms. Kim Min-sun Anti-US Beef Actress Prevails in Court

http://usdavskorea.blogspot.com/2010/02/honorable-ms-kim-min-sun-anti-us-beef.html

update over, back to original blog below...tss

re-Human Prion Diseases in the United States Posted by flounder on 01 Jan 2010 at 18:11 GMT

http://www.plosone.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd&root=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd

Saturday, August 22, 2009

FREE Kim Min-sun, she is correct about mad cow fears from USDA BEEF

http://usdavskorea.blogspot.com/2009/08/free-kim-min-sun-she-is-correct-about.html

Friday, May 9, 2008

USDA VS KOREA typical or atypical BSe

http://usdavskorea.blogspot.com/2008/05/usda-vs-korea-typical-or-atypical-bse.html

Tuesday, April 14, 2009

Tons of USA Beef Suspected of Mad Cow Disease Sold KOREA

http://usdavskorea.blogspot.com/2009/04/tons-of-usa-beef-suspected-of-mad-cow.html

SEE google Korea, SINGELTARY KOREA ;

http://www.google.co.kr/search?complete=1&hl=ko&q=terry+s.+singeltary+sr.&btnG=%EA%B2%80%EC%83%89&lr=lang_ko&aq=f&oq=

THOSE PROTESTERS HAD EVERY REASON TO BE PROTESTING...TSS

Members of The HSUS are also concerned about the meat products provided to their children through the National School Lunch Program. More than 31 million school children receive lunches through the program each school day. To assist states in providing healthful, low-cost or free meals, USDA provides states with various commodities including ground beef. As evidenced by the HallmarkNVestland investigation and recall, the potential for downed animals to make their way into the National School Lunch Program is neither speculative nor hypothetical.

http://biotech.law.lsu.edu/cases/FDA/hsus-v-schafer-usda-complaint.pdf

Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME.

snip...

The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...

http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf

Friday, September 4, 2009

FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009

http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html

Saturday, August 29, 2009

FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html

C O N F I R M E D

----- Original Message ----- From: "Terry S. Singeltary Sr." To: Sent: Thursday, November 05, 2009 9:25 PM Subject: [BSE-L] re-FOIA REQUEST ON FEED RECALL PRODUCT contaminated with prohibited material Recall # V-258-2009 and Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html

Thursday, November 12, 2009

BSE FEED RECALL Misbranding of product by partial label removal to hide original source of materials 2009

http://madcowfeed.blogspot.com/2009/11/bse-feed-recall-misbranding-of-product.html

PLEASE be aware, for 4 years, the USDA fed our children all across the Nation dead stock downer cows, the most high risk cattle for BSE aka mad cow disease and other dangerous pathogens. who will watch our children for CJD for the next 5+ decades ???

SCHOOL LUNCH PROGRAM FROM DOWNER CATTLE UPDATE

http://downercattle.blogspot.com/2009/05/who-will-watch-children.html

http://downercattle.blogspot.com/

please see full text here ;

Tuesday, November 17, 2009

SEAC EFFECT OF AGE ON THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES SEAC 103/2

http://downercattle.blogspot.com/2009/11/seac-effect-of-age-on-pathogenesis-of.html

Sunday, September 6, 2009

MAD COW USA 1997 SECRET VIDEO

SEE ANOTHER VIDEO THAT SHOWED IN CANADA, BUT NOT USA, ABOUT ANOTHER USA TSE COVER-UP MORE BRAINS NOT TESTED PROPERLY, key brain parts missing. ...

http://madcowusda.blogspot.com/2009/09/mad-cow-usa-1997-video.html

SEE THIS DAMNING VIDEO AT BOTTOM OF ;

Monday, July 27, 2009

U.S.A. HIDING MAD COW DISEASE VICTIMS AS SPORADIC CJD ?

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON PRIONS SPEAKING ABOUT ANN VENEMAN

''nobody has ever ask''

''they dont want our comment''

''they don't want to know, the don't care''

''i have tried repeatedly''

''level of absolute ignorance''

''Entire policy was driven...heard from mr. laycraft, so now, after time has passed, it's ok for Canada, cattle under 30 month, to the USA, THAT'S ALL THAT MATTERED!

PRUSINER ASKED : IF FROM YOUR TESTIMONY, A DEMONSTRATED THREAT TO PUBLIC HEATH ?

''yes, i think prions are bad to eat, and you can die from them''

http://maddeer.org/video/embedded/prusinerclip.html

2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006

http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html

The most recent assessments (and reassessments) were published in June 2005 (Table I; 18), and included the categorisation of Canada, the USA, and Mexico as GBR III. Although only Canada and the USA have reported cases, the historically open system of trade in North America suggests that it is likely that BSE is present also in Mexico.

http://www.oie.int/boutique/extrait/06heim937950.pdf

IN A NUT SHELL ;

(Adopted by the International Committee of the OIE on 23 May 2006)

11. Information published by the OIE is derived from appropriate declarations made by the official Veterinary Services of Member Countries. The OIE is not responsible for inaccurate publication of country disease status based on inaccurate information or changes in epidemiological status or other significant events that were not promptly reported to the Central Bureau,

http://www.oie.int/eng/Session2007/RF2006.pdf

Docket APHIS-2006-0026 Docket Title Bovine Spongiform Encephalopathy; Animal Identification and Importation of Commodities Docket Type Rulemaking Document APHIS-2006-0026-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions, Identification of Ruminants and Processing and Importation of Commodities Public Submission APHIS-2006-0026-0012 Public Submission Title Comment from Terry S Singletary

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801e47e1

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028 Public Submission Title Comment from Terry S Singletary

Comment 2006-2007 USA AND OIE POISONING GLOBE WITH BSE MRR POLICY

THE USA is in a most unique situation, one of unknown circumstances with human and animal TSE. THE USA has the most documented TSE in different species to date, with substrains growing in those species (BSE/BASE in cattle and CWD in deer and elk, there is evidence here with different strains), and we know that sheep scrapie has over 20 strains of the typical scrapie with atypical scrapie documented and also BSE is very likely to have passed to sheep. all of which have been rendered and fed back to animals for human and animal consumption, a frightening scenario. WE do not know the outcome, and to play with human life around the globe with the very likely TSE tainted products from the USA, in my opinion is like playing Russian roulette, of long duration, with potential long and enduring consequences, of which once done, cannot be undone. These are the facts as I have come to know through daily and extensive research of TSE over 9 years, since 12/14/97. I do not pretend to have all the answers, but i do know to continue to believe in the ukbsenvcjd only theory of transmission to humans of only this one strain from only this one TSE from only this one part of the globe, will only lead to further failures, and needless exposure to humans from all strains of TSE, and possibly many more needless deaths from TSE via a multitude of proven routes and sources via many studies with primates and rodents and other species.

MY personal belief, since you ask, is that not only the Canadian border, but the USA border, and the Mexican border should be sealed up tighter than a drum for exporting there TSE tainted products, until a validated, 100% sensitive test is available, and all animals for human and animal consumption are tested. all we are doing is the exact same thing the UK did with there mad cow poisoning when they exported it all over the globe, all the while knowing what they were doing. this BSE MRR policy is nothing more than a legal tool to do just exactly what the UK did, thanks to the OIE and GW, it's legal now. and they executed Saddam for poisoning ???

go figure. ...

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8151

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028.1 Public Submission Title Attachment to Singletary comment

January 28, 2007

Greetings APHIS,

I would kindly like to submit the following to ;

BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01

http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f8152&disposition=attachment&contentType=msw8

Monday, November 23, 2009

BSE GBR RISK ASSESSMENTS UPDATE NOVEMBER 23, 2009 COMMISSION OF THE EUROPEAN COMMUNITIES AND O.I.E.

http://docket-aphis-2006-0041.blogspot.com/2009/11/bse-gbr-risk-assessments-update.html

Saturday, January 2, 2010

Human Prion Diseases in the United States January 1, 2010 ***FINAL***

http://prionunitusaupdate2008.blogspot.com/2010/01/human-prion-diseases-in-united-states.html

my comments to PLosone here ;

http://www.plosone.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd&root=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd

JOURNAL OF NEUROLOGY

MARCH 26, 2003

Send Post-Publication Peer Review to journal:

Re: RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States

Email Terry S. Singeltary:

flounder@wt.net

I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to comment on the CDC's attempts to monitor the occurrence of emerging forms of CJD. Asante, Collinge et al [1] have reported that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest sporadic CJD. However, CJD and all human TSEs are not reportable nationally. CJD and all human TSEs must be made reportable in every state and internationally. I hope that the CDC does not continue to expect us to still believe that the 85%+ of all CJD cases which are sporadic are all spontaneous, without route/source. We have many TSEs in the USA in both animal and man. CWD in deer/elk is spreading rapidly and CWD does transmit to mink, ferret, cattle, and squirrel monkey by intracerebral inoculation. With the known incubation periods in other TSEs, oral transmission studies of CWD may take much longer. Every victim/family of CJD/TSEs should be asked about route and source of this agent. To prolong this will only spread the agent and needlessly expose others. In light of the findings of Asante and Collinge et al, there should be drastic measures to safeguard the medical and surgical arena from sporadic CJDs and all human TSEs. I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?

http://www.neurology.org/cgi/eletters/60/2/176#535

LANCET INFECTIOUS DISEASE JOURNAL

Volume 3, Number 8 01 August 2003

Newsdesk

Tracking spongiform encephalopathies in North America

Xavier Bosch

My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth.

http://infection.thelancet.com/journal/journal.isa

Diagnosis and Reporting of Creutzfeldt-Jakob Disease Singeltary, Sr et al. JAMA.2001; 285: 733-734. Vol. 285 No. 6, February 14, 2001 JAMA

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

To the Editor: In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical cases. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationwide and internationally.

Terry S. Singeltary, Sr Bacliff, Tex

1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323. FREE FULL TEXT

http://jama.ama-assn.org/cgi/content/extract/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

http://jama.ama-assn.org/cgi/content/full/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

2 January 2000

British Medical Journal

U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well

http://www.bmj.com/cgi/eletters/320/7226/8/b#6117

15 November 1999

British Medical Journal

vCJD in the USA * BSE in U.S.

http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406

THE PATHOLOGICAL PROTEIN

BY Philip Yam

Yam Philip Yam News Editor Scientific American www.sciam.com

http://www.thepathologicalprotein.com/

WHAT about atypical BSE TSE ??? Some atypical BSE i.e. the l-BSE is more virulent, and the data on h-BSE is still out, but we do know that h-BSE is capable of transmitting to humans. With an incubation period as such with human and animal TSE, the known transmission studies of confirmed transmission of different TSE, and all the unknowns still, I think it is absolutely asinine to even consider this. It's sad, and very concerning that man never learns from his mistakes.

Stupid is, as Stupid does. ...Forest Gump. ...TSS

Wednesday, January 13, 2010

Meat and bone meal back into feed 12 Jan 2010

http://madcowfeed.blogspot.com/2010/01/meat-and-bone-meal-back-into-feed-12.html

JOINT STATEMENT FROM USTR, USDA ON TAIWAN'S ACTIONS TO UNJUSTIFIABLY RESTRICT U.S. BEEF IMPORTS IN VIOLATION OF OUR BILATERAL AGREEMENT

2010-01-05T13:17:00.000-08:00

Release No. 0002.10 Contact: USTR, Nefeterius McPherson (202) 395-3230 USDA, Caleb Weaver (202) 720-4623

JOINT STATEMENT FROM USTR, USDA ON TAIWAN'S ACTIONS TO UNJUSTIFIABLY RESTRICT U.S. BEEF IMPORTS IN VIOLATION OF OUR BILATERAL AGREEMENT

WASHINGTON, January 5, 2010 - The Office of the United States Trade Representative and the U.S. Department of Agriculture today released a statement regarding the decision by Taiwan's Legislative Yuan to bar import of some U.S. beef and beef products. The following statement is from Deputy United States Trade Representative Demetrios Marantis and Undersecretary for Farm and Foreign Agricultural Services Jim Miller:

"We are deeply disappointed with the decision by Taiwan's Legislative Yuan to amend the Food Sanitation Act (FSA) to unjustifiably bar the import of certain U.S. beef and beef products.

"As we noted in our statement on December 29, the FSA amendment's provisions do not have a basis in science and constitute a unilateral violation of a bilateral agreement concluded in good faith by the United States with Taiwan a little over two months ago. The protocol was negotiated on the basis of the guidelines laid out by the World Organization for Animal Health (the OIE), as well as the findings of Taiwan's own risk assessment, which concluded that all U.S. beef and beef products are safe.

"The decision by Taiwan authorities to place domestic politics over science raises serious concerns. This action will also undermine Taiwan's credibility as a responsible trading partner and will make it more challenging for us to conclude future agreements to expand and strengthen bilateral trade and economic ties.

"The decision to violate our bilateral agreement is particularly disappointing, as the United States has long been one of Taiwan's most important trade and investment partners, as well as the strongest supporter of Taiwan's active participation in the global trading system, including its membership in the World Trade Organization (WTO). In light of the continuing importance of our bilateral economic relationship, we urge Taiwan to honor its commitments and to implement the beef protocol as negotiated."

BACKGROUND

The United States has implemented a comprehensive set of measures, regulations, and practices that are science-based, consistent with the guidelines of the OIE for minimizing the risk posed by Bovine Spongiform Encephalopathy (BSE). The OIE is recognized by the WTO as the relevant standard-setting body for regulations relating to animal health. These measures allow us to assure consumers in the United States, Taiwan and elsewhere that U.S. beef and beef products - including offals and ground beef - are safe. Millions of American families enjoy these products every day.

In June 2007, the United States requested that Taiwan provide market expansion for all U.S. beef and beef products consistent with the OIE classification of the United States as a controlled-risk country. Since then, the United States has worked closely with Taiwan to provide all information necessary for Taiwan to fully evaluate these measures in the preparation of the Department of Health's final risk assessment, released by the Department of Health in January 2009, which determined that all U.S. beef and beef products are safe. In the interests of science-based trade with Taiwan, the United States has provided research, data, scientific experts, technical assistance, and detailed information regarding U.S. risk mitigation measures, as well as facilitated two on-site visits to major U.S. exporting beef establishments for Taiwan experts, all of which have underscored the safety of the relevant U.S. beef and beef products.

After over two years of extensive negotiations and scientific and technical exchanges, we concluded an agreement, the "Protocol of Bovine Spongiform Encephalopathy (BSE)-Related Measures for the Importation of Beef and Beef Products for Human Consumption from the Territory of the Authorities Represented by the American Institute in Taiwan (AIT)," on expanded market access for U.S. beef and beef products. The Protocol is science-based, consistent with the OIE guidelines, the domestic legal obligations of both sides, as well as the findings of Taiwan's own risk assessment. The Protocol thus provides further assurances that U.S. beef and beef products to be exported to Taiwan - which are the same products that are consumed by Americans at home - are safe.

Taiwan announced that the protocol would enter into force on November 2, 2009.

Under the terms of the Protocol, all tissues that are scientifically recognized as posing a risk of BSE, known as specified risk materials (SRMs), must be removed, and no SRMs or beef containing SRMs will be eligible for export to Taiwan. These tissues are tonsils and distal ileum from cattle of all ages and also the brain, eyes, spinal cord, skull, dorsal root ganglia, and vertebral column from cattle 30 months of age and older. This list excludes the vertebrae of the tail, the transverse processes of the thoracic and lumbar vertebrae, and the wings of the sacrum.

The Protocol is designed to both ensure human health and provide a clear and predictable commercial environment. The protocol specifies the actions that will be taken in response to instances of non-compliance that constitute food safety hazards, as well as to those that are unrelated to food safety. Taiwan will apply the same inspection procedures and border measures to U.S. beef imports that it applies to all imports from other countries.

The Protocol establishes a consultation mechanism under which both sides will have the opportunity to request consultations as needed to address any issues that may arise in the implementation of the Protocol.

While the Protocol allows trade in beef and beef products from cattle of any age, provided that SRM tissues are removed, the U.S. beef exporting industry has committed to voluntarily limit beef exports to Taiwan during a transitional period to products beef and beef products from cattle less than 30 months of age under a Quality Systems Assessment program verified by USDA.

# USDA News oc.news@usda.gov 202 720-4623

http://www.usda.gov/wps/portal/!ut/p/_s.7_0_A/7_0_1OB?contentidonly=true&contentid=2010/01/0002.xml

Greetings Taiwan et al !

Can anyone blame Taiwan for banning USA beef? I applaud Taiwan for standing up to the USA and their junk science, and trying to protect their consumers. The USA has been covering up mad cow disease for over a decade. The OIG and the GAO have proven, time and time again, the failures and flaws with the USA BSE surveillance, and then they hide behind the infamous triple firewall of the failed, partial and voluntary feed ban of August 4, 1997. This was nothing but ink on paper, it was never enforceable. nope, all the USA does is blame everything on Canada. what they really need to do is stand if front of a mirror and take a good look at themselves. The USDA's NSLP for over 4 years fed dead stock downer cows to our children all across the Nation. These are the most high risk cattle for mad cow disease and other dangerous pathogens. IF the USDA et al are willing to feed this crap to our Children, do you think for one second they would not feed it to the Honorable people of Taiwan? They MUST demand, TEST, TEST, TEST !!! The USA could test every cow for mad cow disease if they chose, the refuse because they know what they will find. ... in my opinion...TSS

Tuesday, December 29, 2009

Taiwan to resume USA beef ban over mad cow disease threat

http://usdavskorea.blogspot.com/2009/12/taiwan-to-resume-usa-beef-ban-over-mad.html

Tuesday, November 10, 2009

Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan and USA

http://usdavskorea.blogspot.com/2009/11/surveillance-on-bovine-spongiform.html

Monday, November 30, 2009

Taiwan, USDA, and USA beef, what the consumer does not know, could kill them

http://usdavskorea.blogspot.com/2009/11/taiwan-usda-and-usa-beef-what-consumer.html

Thursday, November 12, 2009

BSE FEED RECALL Misbranding of product by partial label removal to hide original source of materials 2009

http://madcowfeed.blogspot.com/2009/11/bse-feed-recall-misbranding-of-product.html

http://madcowtesting.blogspot.com/

Saturday, January 2, 2010

Human Prion Diseases in the United States January 1, 2010 ***FINAL***

http://prionunitusaupdate2008.blogspot.com/2010/01/human-prion-diseases-in-united-states.html

my comments to PLosone here ;

http://www.plosone.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd&root=info%3Adoi%2F10.1371%2Fannotation%2F04ce2b24-613d-46e6-9802-4131e2bfa6fd

>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — at the average rate of one every six weeks...<<< http://downercattle.blogspot.com/2009/09/suit-meatpacker-used-downer-cows-for-4.html

do you actually believe all these schools recalled this meat because of a few cattle being abused, see which schools recalled products due to suspect beef, in any given state, see if your kids were exposed to these dead stock downer cows, and whatever disease they may have had, and remember, cooking does NOT kill the PrP agent.

see list ;

FNS All Regions Affected School Food Authorities By State United States Department of Agriculture Food and Nutrition Service National School Lunch Program March 24, 2008 School Food Authorities Affected by Hallmark/Westland Meat Packing Co. Beef Recall February 2006 - February 2008

http://www.fns.usda.gov/fns/safety/Hallmark-Westland_byState.pdf

IF the url fails, go to this site ;

http://www.fns.usda.gov/fns/

left hand corner search ;

Hallmark/Westland Meat Packing Co. Beef Recall

you should get this ;

http://65.216.150.153/texis/search?pr=FNS

1 through 1 of 1 matching documents, best matches first. sort by date 1: Hallmark - Westland SFA Reporting by State - 3-24-2008.xls Lunch Program March 24, 2008 School Food Authorities Affected by Hallmark/Westland Meat Packing Co. Beef Recall February 2006 - February 2008 The U.S. Department of Agriculture ...

http://www.fns.usda.gov/fns/safety/Hallmark-Westland_byState.pdf#xml=http://65.216.150.153/texis/search/pdfhi.txt?query=Hallmark/Westland+Meat+Packing+Co.+Beef+Recall&pr=FNS&prox=page&rorder=500&rprox=500&rdfreq=500&rwfreq=500&rlead=500&rdepth=0&sufs=0&order=r&cq=&id=4ace90e711

Members of The HSUS are also concerned about the meat products provided to their children through the National School Lunch Program. More than 31 million school children receive lunches through the program each school day. To assist states in providing healthful, low-cost or free meals, USDA provides states with various commodities including ground beef. As evidenced by the HallmarkNVestland investigation and recall, the potential for downed animals to make their way into the National School Lunch Program is neither speculative nor hypothetical.

http://biotech.law.lsu.edu/cases/FDA/hsus-v-schafer-usda-complaint.pdf

Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME. snip... The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...

http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf

Friday, September 4, 2009

FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009

http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html

Saturday, August 29, 2009

FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html

F.O.I.A. CONFIRMED BSE MAD COW RELATED

----- Original Message ----- From: "Terry S. Singeltary Sr." To: Sent: Thursday, November 05, 2009 9:25 PM Subject: [BSE-L] re-FOIA REQUEST ON FEED RECALL PRODUCT contaminated with prohibited material Recall # V-258-2009 and Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html

http://madcowfeed.blogspot.com/

PLEASE be aware, for 4 years, the USDA fed our children all across the Nation dead stock downer cows, the most high risk cattle for BSE aka mad cow disease and other dangerous pathogens. who will watch our children for CJD for the next 5+ decades ???

SCHOOL LUNCH PROGRAM FROM DOWNER CATTLE UPDATE

http://downercattle.blogspot.com/2009/05/who-will-watch-children.html

http://downercattle.blogspot.com/

please see full text here ;

Tuesday, November 17, 2009

SEAC EFFECT OF AGE ON THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES SEAC 103/2

http://downercattle.blogspot.com/2009/11/seac-effect-of-age-on-pathogenesis-of.html

Wednesday, November 18, 2009

R-CALF: 40 Groups Disagree With USDA's Latest BSE Court Submission

http://bse-atypical.blogspot.com/2009/11/r-calf-40-groups-disagree-with-usdas.html

Monday, October 19, 2009

Atypical BSE, BSE, and other human and animal TSE in North America Update October 19, 2009

http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html

Sunday, September 6, 2009

MAD COW USA 1997 SECRET VIDEO

http://madcowusda.blogspot.com/2009/09/mad-cow-usa-1997-video.html

U.S.A. HIDING MAD COW DISEASE VICTIMS AS SPORADIC CJD ? see video at bottom

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON PRIONS SPEAKING ABOUT ANN VENEMAN see video

http://maddeer.org/video/embedded/prusinerclip.html

Tuesday, August 04, 2009

Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

http://chronic-wasting-disease.blogspot.com/2009/08/susceptibilities-of-nonhuman-primates.html

http://chronic-wasting-disease.blogspot.com/

Monday, December 14, 2009 *** RIP MOM DOD 12/14/97

Similarities between Forms of Sheep Scrapie and Creutzfeldt-Jakob Disease Are Encoded by Distinct Prion Types

http://nor-98.blogspot.com/2009/12/similarities-between-forms-of-sheep.html

Monday, November 30, 2009

USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE

http://nor-98.blogspot.com/2009/11/usda-and-oie-collaborate-to-exclude.html

Monday, November 23, 2009

BSE GBR RISK ASSESSMENTS UPDATE NOVEMBER 23, 2009 COMMISSION OF THE EUROPEAN COMMUNITIES AND O.I.E.

http://docket-aphis-2006-0041.blogspot.com/2009/11/bse-gbr-risk-assessments-update.html

IN A NUT SHELL ;

(Adopted by the International Committee of the OIE on 23 May 2006)

11. Information published by the OIE is derived from appropriate declarations made by the official Veterinary Services of Member Countries. The OIE is not responsible for inaccurate publication of country disease status based on inaccurate information or changes in epidemiological status or other significant events that were not promptly reported to the Central Bureau,

http://www.oie.int/eng/Session2007/RF2006.pdf

Docket APHIS-2006-0026 Docket Title Bovine Spongiform Encephalopathy; Animal Identification and Importation of Commodities Docket Type Rulemaking Document APHIS-2006-0026-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions, Identification of Ruminants and Processing and Importation of Commodities Public Submission APHIS-2006-0026-0012 Public Submission Title Comment from Terry S Singletary

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801e47e1

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028 Public Submission Title Comment from Terry S Singletary

Comment 2006-2007 USA AND OIE POISONING GLOBE WITH BSE MRR POLICY

THE USA is in a most unique situation, one of unknown circumstances with human and animal TSE. THE USA has the most documented TSE in different species to date, with substrains growing in those species (BSE/BASE in cattle and CWD in deer and elk, there is evidence here with different strains), and we know that sheep scrapie has over 20 strains of the typical scrapie with atypical scrapie documented and also BSE is very likely to have passed to sheep. all of which have been rendered and fed back to animals for human and animal consumption, a frightening scenario. WE do not know the outcome, and to play with human life around the globe with the very likely TSE tainted products from the USA, in my opinion is like playing Russian roulette, of long duration, with potential long and enduring consequences, of which once done, cannot be undone. These are the facts as I have come to know through daily and extensive research of TSE over 9 years, since 12/14/97. I do not pretend to have all the answers, but i do know to continue to believe in the ukbsenvcjd only theory of transmission to humans of only this one strain from only this one TSE from only this one part of the globe, will only lead to further failures, and needless exposure to humans from all strains of TSE, and possibly many more needless deaths from TSE via a multitude of proven routes and sources via many studies with primates and rodents and other species.

MY personal belief, since you ask, is that not only the Canadian border, but the USA border, and the Mexican border should be sealed up tighter than a drum for exporting there TSE tainted products, until a validated, 100% sensitive test is available, and all animals for human and animal consumption are tested. all we are doing is the exact same thing the UK did with there mad cow poisoning when they exported it all over the globe, all the while knowing what they were doing. this BSE MRR policy is nothing more than a legal tool to do just exactly what the UK did, thanks to the OIE and GW, it's legal now. and they executed Saddam for poisoning ???

go figure. ...

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8151

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028.1 Public Submission Title Attachment to Singletary comment

January 28, 2007

Greetings APHIS,

I would kindly like to submit the following to ;

BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01

http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f8152&disposition=attachment&contentType=msw8

SEE CJD PRION DISEASES AND ALZHEIMER'S

Monday, January 4, 2010

Rising Tide: The Impact of Dementia in Canada Huge wave of dementia cases coming, warns report

http://betaamyloidcjd.blogspot.com/2010/01/rising-tide-impact-of-dementia-in.html

http://betaamyloidcjd.blogspot.com/

Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

Taiwan to resume USA beef ban over mad cow disease threat

2009-12-29T16:02:00.000-08:00

Dec 29, 2009 Taiwan to resume beef ban

TAIPEI - TAIWAN said on Tuesday it would resume a ban on certain US beef imports amid public concerns over mad cow disease.

Lawmakers agreed to amend a law on food health to ban imports of cow organs, minced beef and other high-risk items such as spines and eyes, said Lu Hsueh-chang, parliamentary whip of the ruling Kuomintang party.

The decision was to be finalised next month in a vote that would furthermore determine whether beef-on-the-bone should also be banned, he said. The move will partially overturn a decision by the health department to allow imports of US beef-on-the-bone and cow organs, which was met with a public outcry. ...snip...end

full text ;

http://www.straitstimes.com/BreakingNews/Asia/Story/STIStory_471617.html

VERY SMART MOVE TAIWAN !

Release No. 0629.09 Contact: Deborah Mesloh, USTR (202) 395-3230 Chris Mather, USDA (202) 720-4623

Printable version Email this page

JOINT STATEMENT FROM USTR, USDA ON THE PROPOSED PASSAGE OF AN AMENDMENT TO TAIWAN'S FOOD SANITATION ACT

WASHINGTON, Dec. 29, 2009 - The Office of the United States Trade Representative and the U.S. Department of Agriculture today released a brief statement regarding the Taiwan Legislative Yuan's completion of initial steps toward passing an amendment to Taiwan's Food Sanitation Act that bars import of some U.S. beef and beef products. The following statement is from Deputy United States Trade Representative Demetrios Marantis and Undersecretary for Farm and Foreign Agricultural Services Jim Miller:

"We are deeply concerned and disappointed by reports that Taiwan's Legislative Yuan has taken initial steps toward the passage of an amendment to the Food Sanitation Act that contains provisions that would unjustifiably bar the import of certain U.S. beef and beef products.

"This amendment's provisions do not have a basis in science or fact and thus in no way serve to protect Taiwan's food supply. If passed, this amendment would represent a new barrier to U.S. beef exports to Taiwan, and would constitute a unilateral abrogation of a bilateral agreement concluded in good faith by the United States with Taiwan just two months ago. The Taiwan authorities should consider very carefully the impact that passage of the amendment in its current form would have on Taiwan's reputation as a reliable trading partner and responsible member of the international community. Science and facts - not politics or hyperbole - should govern our trade and economic relations.

"The United States has implemented a comprehensive set of measures, regulations, and practices that are science-based, consistent with the guidelines of the World Organization for Animal Health (OIE) for minimizing the risk posed by BSE. The OIE is recognized by the World Trade Organization (WTO) as the relevant standard-setting body for regulations relating to animal health. These measures allow us to ensure consumers in the United States, Taiwan and elsewhere that U.S. beef and beef products --including offals and ground beef -- are safe, and millions of American families enjoy these products every day.

"We have worked closely with Taiwan to provide all information necessary for Taiwan to fully evaluate these measures in the preparation of the Department of Health's final risk assessment, which determined that U.S. beef and beef products are safe. In the interests of science-based trade with Taiwan, the United States has provided research, data, scientific experts, technical assistance, as well as detailed information regarding U.S. risk mitigation measures, all of which have underscored the safety of the relevant U.S. beef and beef products.

"After over two years of extensive negotiations and scientific and technical exchanges, we concluded an agreement, the "Protocol of Bovine Spongiform Encephalopathy (BSE)-Related Measures for the Importation of Beef and Beef Products for Human Consumption from the Territory of the Authorities Represented by the American Institute in Taiwan (AIT)," on expanded market access for U.S. beef and beef products. The Protocol is science-based, consistent with the OIE guidelines, the domestic legal obligations of both sides, as well as the findings of Taiwan's own risk assessment. The Protocol thus provides further assurances that U.S. beef and beef products to be exported to Taiwan - which are the same products that are consumed by Americans at home - are safe.

"This is a serious matter that concerns us greatly and we are monitoring the legislative process very closely."

#

USDA is an equal opportunity provider, employer and lender. To file a complaint of discrimination, write: USDA, Director, Office of Civil Rights, 1400 Independence Ave., SW, Washington, DC 20250-9410 or call (800) 795-3272 (voice), or (202) 720-6382 (TDD).

http://www.usda.gov/wps/portal/!ut/p/_s.7_0_A/7_0_1OB?contentidonly=true&contentid=2009/12/0629.xml

To better quantify the impact of foodborne diseases on health in the United States, we compiled and analyzed information from multiple surveillance systems and other sources. We estimate that foodborne diseases cause approximately 76 million illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States each year. Known pathogens account for an estimated 14 million illnesses, 60,000 hospitalizations, and 1,800 deaths. Three pathogens, Salmonella, Listeria, and Toxoplasma, are responsible for 1,500 deaths each year, more than 75% of those caused by known pathogens, while unknown agents account for the remaining 62 million illnesses, 265,000 hospitalizations, and 3,200 deaths. Overall, foodborne diseases appear to cause more illnesses but fewer deaths than previously estimated.

http://www.cdc.gov/ncidod/eid/vol5no5/mead.htm

Included in the report are five sections, each written by a physician specializing in the field, outlining the health problems caused by five pathogens: Campylobacter linked to Guillian-Barre Syndrome; E. coli O157:H7 linked to HUS and other long-term complications; Listeria monocytogenes linked to premature death and brain infections; Salmonella and other pathogens linked to Reactive arthritis (ReA), and Toxoplasma gondii linked to mental retardation and effects on vision.

The full report, The Long-Term Health Outcomes of Selected Foodborne Pathogens, can be read at www.foodborneillness.org

http://www.foodborneillness.org/CFIExecSummary.pdf

http://www.foodborneillness.org/CFIFinalReport.pdf

Foodborne Pathogens and Disease

The Effects of Transport and Lairage on Counts of Escherichia coli O157 in the Feces and on the Hides of Individual Cattle

--------------------------------------------------------------------------------

To cite this article: Narelle Fegan, Glen Higgs, Lesley L. Duffy, Robert S. Barlow. Foodborne Pathogens and Disease. November 2009, 6(9): 1113-1120. doi:10.1089/fpd.2009.0338.

-------------------------------------------------------------------------------- Published in Volume: 6 Issue 9: November 4, 2009 Online Ahead of Print: July 24, 2009

--------------------------------------------------------------------------------

Full Text: • PDF for printing (4,681.3 KB) • PDF w/ links (155.8 KB)

Narelle Fegan,1 Glen Higgs,2 Lesley L. Duffy,2 and Robert S. Barlow2 1Food Science Australia, CSIRO, Werribee, Victoria, Australia. 2Food Science Australia, CSIRO, Brisbane, Queensland, Australia. Address correspondence to:

Narelle Fegan, Ph.D.

Food Science Australia, CSIRO

671 Sneydes Road

Werribee, Victoria 3030

Australia E-mail: Abstract

Objectives: The main objective of this study was to determine the impact of transport and lairage on the isolation rate and the number of Escherichia coli O157 on cattle.

Materials: Ninety animals, divided into three groups (A, B, and C) of 30 animals each, were used in this study. Individual animals were tagged, and samples were collected from the hides and feces of each at a feedlot and again after slaughter. The carcass of each animal was also sampled. Samples were also collected from the feedlot pens, the sides and floors of the transport trucks, and abattoir holding pens. The isolation rate and the number of E. coli O157 were estimated using a combination of immunomagnetic separation and the Most Probable Number technique.

Results: Cattle hides were more likely to be contaminated with E. coli O157 at the feedlot (31%) than at the abattoir (4%). E. coli O157 was detected in 18% and 12% of cattle feces collected at the feedlot and after slaughter, respectively. E. coli O157 was isolated from truck floors (26%), truck sides (11%), abattoir pen rails (47%), and pen floors (42%). The mean count of E. coli O157 in positive feces was log10 1.17 and 2.37MPN/g at the feedlot and slaughter, respectively. A 3 log10 increase in the number of E. coli O157 was observed between the feedlot (2.66MPN/g) and slaughter (5.66MPN/g) in the feces of one animal in group B. E. coli O157 was isolated from the hide and carcass of this animal.

Conclusions: Transport and lairage did not lead to an increase in the number or isolation rate of E. coli O157 from cattle.

Applications: Intervention strategies for reducing E. coli O157 contamination of cattle carcasses should target mechanisms that limit the impact of animals shedding a high number throughout production and processing.

http://www.liebertonline.com/doi/abs/10.1089/fpd.2009.0338?prevSearch=allfield%253A%2528e%2Bcoli%2529&searchHistoryKey=

CLASS I RECALL Congressional and Public Affairs HEALTH RISK: HIGH Atiya Khan (202) 720-9113 FSIS-RC-059-2009 NEW YORK FIRM RECALLS FRESH GROUND BEEF PRODUCTS DUE TO POSSIBLE E. COLI O157:H7 CONTAMINATION WASHINGTON, October 31, 2009 – Fairbank Farms, an Ashville, NY, establishment, is recalling approximately 545,699 pounds of fresh ground beef products that may be contaminated with E. coli O157:H7, the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) announced today. FSIS became aware of the problem during the course of an investigation of a cluster of E. coli O157:H7 illnesses. Working with the Centers for Disease Control and Prevention (CDC) and state health and agriculture departments, FSIS determined that there is an association between the fresh ground beef products subject to recall and illnesses in Connecticut, Maine and Massachusetts. FSIS is continuing to work with the Massachusetts Department of Public Health, the Connecticut Department of Public Health, other state health and agriculture departments and the CDC on the investigation. Anyone with signs or symptoms of foodborne illness should consult a physician. The following products are subject to recall: Trader Joe’s • 1-pound packages of “TRADER JOE’S BUTCHER SHOP FINE QUALITY MEATS GROUND BEEF 85/15.” • 1-pound packages of “TRADER JOE’S BUTCHER SHOP FINE QUALITY MEATS GROUND BEEF 80/20.” NOTE: The sell-by dates for the above two products may be October 6 or 7, 2009. • 1-pound trays of “TRADER JOE’S BUTCHER SHOP FINE QUALITY MEATS GROUND BEEF PATTIES 96/4 EXTRA LEAN.” • 1-pound trays of “TRADER JOE’S BUTCHER SHOP FINE QUALITY MEATS GROUND BEEF PATTIES 85/15.” Price Chopper • 1- and 2.5-pound trays of “PRICE CHOPPER MEATLOAF & MEATBALL MIX.” • 1-pound trays of “PRICE CHOPPER EXTRA LEAN GROUND BEEF 96/4.” • 1-pound trays of “PRICE CHOPPER FRESH GROUND BEEF CHUCK FOR CHILI 80% LEAN 20% FAT.” Lancaster and Wild Harvest • 1-pound trays of “LANCASTER BRAND 96/4 EXTRA LEAN GROUND BEEF.” • 1- and 2-pound trays of “LANCASTER BRAND 90/10 GROUND BEEF.” • 1-pound trays of “WILD HARVEST NATURAL 85/15 ANGUS GROUND BEEF.” Shaw’s • 1- and 2-pound trays of “SHAW’S FRESH GROUND BEEF 93/7.” • 1-, 2- and 3-pound trays of “SHAW’S FRESH GROUND BEEF 80/20.” • 1- and 3-pound trays of “SHAW’S FRESH GROUND BEEF 75/25.” • 1.3-pound trays of “SHAW’S FRESH GROUND SIRLOIN BEEF PATTIES 90/10.” • 1.3-pound trays of “SHAW’S FRESH GROUND ROUND BEEF PATTIES 85/15.” • 1.3-pound trays of “SHAW’S FRESH GROUND BEEF PATTIES 80/20.” • 3-pound trays of “SHAW’S FRESH GROUND BEEF PATTIES FAMILY PACK 80/20.” • 1-pound trays of “SHAW’S ANGUS GROUND BEEF 85/15.” • 1-, 2- and 3-pound trays of “SHAW’S FRESH GROUND ROUND BEEF 85/15.” • 1-pound trays of “SHAW’S 90% NATURAL GROUND BEEF.” • 1-pound trays of “SHAW’S 85% NATURAL GROUND BEEF.” • 1-, 2- and 3-pound trays of “SHAW’S FRESH GROUND SIRLOIN 90/10.” • 1-pound trays of “MEATLOAF & MEATBALL MIX.” BJ’s • 5-pound trays of “FRESH GROUND BEEF, CONTAINS 15 % FAT” patties. • 3- and 5-pound trays of “LEAN GROUND BEEF, CONTAINS 7% FAT.” • 2.5-pound trays of “MEATLOAF & MEATBALL MIX.” Ford Brothers • 3-pound trays of “FRESH GROUND BEEF, CONTAINS 20% FAT” patties. Giant • 1-pound trays of “GIANT EXTRA LEAN GROUND BEEF 96/4.” • 1-pound trays of “GIANT MEATLOAF & MEATBALL MIX.” • 1-pound trays of “GIANT NATURE’S PROMISE GROUND BEEF.” • 1-pound trays of “GIANT NATURE’S PROMISE GROUND BEEF PATTIES.” Each package bears the establishment number “EST. 492” inside the USDA mark of inspection or on the nutrition label. These products were packaged on September 15 and 16, 2009, and may have been labeled at the retail stores with a sell-by date from September 19 through 28, 2009, unless otherwise noted above. Consumers should ask at their point of purchase if the products they have are subject to recall. The products were sent to distribution centers, intended for further distribution to retail establishments in Northeast and Mid-Atlantic regions. When available, the retail distribution list(s) will be posted on FSIS’ Web site at

http://www.fsis.usda.gov/FSIS_Recalls/Open_Federal_Cases/index.asp.

Products for further processing: • Cases of 10-pound “FAIRBANK FARMS FRESH GROUND BEEF CHUBS.” Each case bears the establishment number “EST. 492” inside the USDA mark of inspection; has package dates of “09.14.09,” “09.15.09,” or “09.16.09;” and sell-by dates of “10.3.09,” “10.4.09,” or “10.5.09. These products were distributed to retail establishments in Maryland, Massachusetts, North Carolina, New Jersey, New York, Pennsylvania, and Virginia for further processing. However, these products at retail will likely not bear the package dates and sell-by dates listed above. Customers with concerns should contact their point of purchase. E. coli O157:H7 is a potentially deadly bacterium that can cause bloody diarrhea, dehydration, and in the most severe cases, kidney failure. The very young, seniors and persons with weak immune systems are the most susceptible to foodborne illness. Individuals concerned about an illness should contact a physician. FSIS routinely conducts recall effectiveness checks to verify recalling firms notify their customers of the recall and that steps are taken to make certain that the product is no longer available to consumers. FSIS advises all consumers to safely prepare their raw meat products, including fresh and frozen, and only consume ground beef or ground beef patties that have been cooked to a temperature of 160° F. The only way to be sure ground beef is cooked to a high enough temperature to kill harmful bacteria is to use a food thermometer to measure the internal temperature. Media questions regarding the recall should be directed the company’s Media Representative, Agnes Schafer at (866) 460-8017. Consumer questions should be directed to the company’s Consumer Hotline at (877) 546-0122. Consumers with food safety questions can “Ask Karen,” the FSIS virtual representative available 24 hours a day at AskKaren.gov. The toll-free USDA Meat and Poultry Hotline 1-888-MPHotline (1-888-674- 6854) is available in English and Spanish and can be reached from l0 a.m. to 4 p.m. (Eastern Time) Monday through Friday. Recorded food safety messages are available 24 hours a day. # NOTE: Access news releases and other information at FSIS’ Web site at

http://www.fsis.usda.gov/Fsis_Recalls/

USDA is an equal opportunity provider, employer and lender. To file a complaint of discrimination, write: USDA, Director, Office of Civil Rights, 1400 Independence Avenue, SW, Washington, DC 20250-9410 or call (800) 795-3272 (voice), or (202) 720-6382 (TDD).

http://www.fairbankfarms.com/059%20%20NY%20E%20%20coli%2010%2031%2009%20FINAL.pdf

CDC: Tainted ground beef may be linked to 2 deaths By BEN DOBBIN (AP) – 19 hours ago

http://www.google.com/search?um=1&cf=all&ned=us&hl=en&q=CDC+TAINTED+GROUND+MEAT+MAY+BE+LINKED+TO+TWO+DEATHS&btnmeta%3Dsearch%3Dsearch=Search+the+Web

Report of the committee Evolutionary Trends of Salmonella enteritidis Linked to Subpopulation Biology and Virulence Attributes a Time Specific Paper was presented by Dr. J. Guard Bouldin, ARS-USDA. The complete text of the presentation is included in these proceedings at the end of this report. Dr. Bouldin reported that Salmonella enterica serovar enteritidis (S. Enteritidis) is currently the world’s leading cause of food borne salmonellosis. It is the only serotype out of over 1400 within Salmonella enterica I that contaminates the internal contents of the egg by vertical transmission from the reproductive tract of otherwise healthy hens. Epidemiological studies have shown that this exceptionally invasive pathogen with an unusual tissue tropism has a more clonal population structure than most other broad-host range Salmonella serotypes. Dr. Guard Bouldin presented research findings that showed how this egg tropism is likely to have occurred. FSIS Salmonella initiatives for meat, poultry, and processed egg products presentation was given by Daniel L. Engeljohn, Office of Policy, Program and Employee Development, FSIS. Dr. Engeljohn presented FSIS’s mission, its public health performance measures, policies on pathogen control including Salmonella. As the public health regulatory agency in USDA, FSIS is responsible for ensuring that the nation’s commercial supply of meat, poultry, and processed egg products are safe, wholesome, and correctly labeled and packaged www.fsis.usda.gov/about_fsis/index.asp. In FY07, FSIS had approximately 7,800 full-time inspectors that visited around 6,200 facilities. Processing establishments receive daily inspection, slaughter establishments receive daily inspection along with every animal afforded a critical inspection before slaughter.

FSIS inspected approximately 44 billion pounds of livestock, 57 billion pounds of poultry, 3.5 billion pounds of liquid egg product, 3.8 billion pounds of product reinspected at the border, and conducted about 8 million inspection procedures. A progress review was presented for the federal Healthy People 2010 program Morbidity and Mortality Weekly Report (MMWR) April 11, 2008; 57(14):366-370

www.cdc.gov/mmwr/preview/mmwrhtml/mm5714a.htm

He described preliminary surveillance data for 2007 and compared them with data for previous years. In 2007, the estimated incidence of infections caused by Campylobacter, Listeria, Shiga toxin-producing Escherichia coli O157 (STEC O157), Salmonella, Shigella, Vibrio, and Yersinia did not change significantly, and Cryptosporidium infections increased compared with 2004--2006. Progress toward the targets for Healthy People 2010 national health objectives and targets regarding the incidence of foodborne infections occurred before 2004; however, none of the targets were reached in 2007. Salmonella incidence was the furthest from its national health target, suggesting that reaching this target will require new approaches.

474

DISCUSSION

Serotyping results are presented for 18,267 Salmonella isolates. This year 44 percent of the isolates were from clinical cases and 56 percent were from monitor samples, compared to 38 percent and 62 percent last year, repectively.1

Of the clinical isolates, 35 percent were of bovine origin and 32 percent were isolated from swine. Thirty-nine percent of the monitor samples were isolated from chickens and 12 percent were recovered from turkeys. A total of 253 serotypes were identified from isolates recovered from animals, their environment, or feed in 40 states and the District of Columbia. The 10 most common serotypes (Table 1) accounted for 58 percent of the total isolates reported. Table 2 lists the 10 most common serotypes by clinical role: those from clinical cases and those from monitor samples. Salmonella Typhimurium, S. Heidelberg, S. Cerro, S. Senftenberg and S. Montevideo are found in both lists. Salmonella Typhimurium was again the most frequently identified serotype from all sources and clinical roles. (Table 1) It was the most common serotype from clinical cases and the third most common serotype from monitor samples (Table 2). Salmonella Typhimurium was among the five most frequently identified serotypes isolated from chickens, swine, horse and dog/cat (Tables 3, 6, 7 and . Fourteen percent of all isolates, 22 percent of isolates from clinical cases, and 8 percent of isolates from monitor samples were identified as S. Typhimurium, compared to 13 percent, 21 percent, and 9 percent, respectively, last year.1 Fifty-one percent of the S. Typhimurium isolates were identified as S. Typhimurium var. Copenhagen this year, compared to 53 percent last year.1 The majority of S. Typhimurium isolates recovered from swine were S. Typhimurium var. Copenhagen (73 percent); whereas 37 percent of isolates of chicken origin were S. Typhimurium var. Copenhagen, and 19 percent of equine origin were S. Typhimurium var. Copenhagen. An untypable serotype 4,5,12:i:- decreased to 164 this year from 262 last year1 and 43 7 in 20062. Sixty-seven of these were isolated from chickens, 20 from cattle, and 25 from horses. This serotype is believed to be S. Typhimurium that has lost the ability to express the phase 2 flagellar antigen. Salmonella Newport was the seventh most frequently identified serotype from all sources (Table 1) and third in clinical cases. (Table 2). It was the fourth most common serotype from clinical cases in cattle (Table 5) and accounted for 6 percent of the isolates of bovine origin. Salmonella salmonella 494 Report of the comite Newport was the second most common serotype from clinical cases in horses (Table 7) and accounted for 5 percent of the isolates of equine origin. Four percent of the total isolates from all sources and all clinical roles were S. Newport, compared with 4 percent last year1, 5 percent in 20062, and 9 percent in 2005.3 The number of Salmonella Enteritidis isolated decreased this year to 551 isolates compared to 774 isolates last year. Fifty-four percent of the isolates were of chicken origin and it was the most frequently identified serotype from chicken clinical cases and the third most common serotype from chicken monitor samples (Table 5). Eleven different phage types were identified among the 329 S. Enteritidis isolates that were phage typed. The most frequently identified phage types were type 8 (54 percent), type 13 (13 percent), and type 23 (11 percent). Two percent were untypable, and 2 percent reacted, but did not conform (RDNC.) Fifteen different phage types were identified among 150 S. Typhimurium isolates that were phage typed. The most common phage types were DT104 and variants (67 percent) and U302 (9 percent). Five percent were untypable and 5 percent reacted, but did not conform.

REFERENCES Morningstar, B.R, et al. 2007. Salmonella Serotypes From Animals and Related Sources Reported During July 2006-June 2007. Proc U.S. Animal Health Assoc.111:633 -635 Morningstar-Flugrad, B.R., et.al. 2006. Salmonella Serotypes From Animals and Related Sources Reported During July 2005-June 2006. Proc U.S. Animal Health Assoc. 110:564-570 Ferris, K.E., et.al. 2005. Salmonella Serotypes From Animals and Related Sources Reported During July 2004- June 2005. Proc U.S. Animal Health Assoc. 109:559-562 Ferris, K.E., et.al. 2004. Salmonella Serotypes From Animals and Related Sources Reported During July 2003- June 2004. Proc U.S. Animal Health Assoc. 108:501-502. Ferris, K.E., et.al. 2003. Salmonella Serotypes From Animals and Related Sources Reported During July 2002- June 2003. Proc U.S. Animal Health Assoc. 107:463-469.

http://www.usaha.org/meetings/2008/2008_USAHA_Proceedings.pdf

Synopses

Food-Related Illness and Death in the United States Paul S. Mead, Laurence Slutsker, Vance Dietz, Linda F. McCaig, Joseph S. Bresee, Craig Shapiro, Patricia M. Griffin, and Robert V. Tauxe Centers for Disease Control and Prevention, Atlanta, Georgia, USA

--------------------------------------------------------------------------------

To better quantify the impact of foodborne diseases on health in the United States, we compiled and analyzed information from multiple surveillance systems and other sources. We estimate that foodborne diseases cause approximately 76 million illnesses, 325,000 hospitalizations, and 5,000 deaths in the United States each year. Known pathogens account for an estimated 14 million illnesses, 60,000 hospitalizations, and 1,800 deaths. Three pathogens, Salmonella, Listeria, and Toxoplasma, are responsible for 1,500 deaths each year, more than 75% of those caused by known pathogens, while unknown agents account for the remaining 62 million illnesses, 265,000 hospitalizations, and 3,200 deaths. Overall, foodborne diseases appear to cause more illnesses but fewer deaths than previously estimated.

http://www.cdc.gov/ncidod/eid/Vol5no5/mead.htm

List of United States foodborne illness outbreaks From Wikipedia, the free encyclopedia Jump to: navigation, search This is a list of foodborne illness outbreaks in the United States. Every year 5,000 deaths, 325,000 hospitalizations and 76 million illnesses are caused by foodborne illnesses within the US.[1] Illness outbreaks lead to food recalls.

Contents [hide] 1 2008 2 2007 3 2006 4 2003 5 2002 6 2001 7 2000 8 1997 9 1996 10 1994 11 1993 12 1992 13 1985 14 1983 15 1977 16 1974 17 1971 18 See also 19 References

http://en.wikipedia.org/wiki/List_of_United_States_foodborne_illness_outbreaks

Recall Case Archive - 2009
Case Number & Recall Notification Report Date Recall Initiated & Press Release Issued Quantity Reported Recovered by Establishment
059-2009, Ground Beef Products (E. coli O157:H7) En Español PDF

Oct 31, 2009 795 pounds
057-2009, South Shore Meats Ground Beef and Beef Steak Products (E. coli O157:H7) En Español PDF

Oct 26, 2009 878 pounds
056-2009, Smoked Beef Brisket (Listeria) En Español PDF

Oct 21, 2009 0 pounds
052-2009, Ground Beef Products (E. Coli O157:H7) En Español PDF

Oct 13, 2009 725 pounds
050-2009, Braunschweiger Liver Sausage (Mislabeling and Undeclared Allergen) En Español PDF

Sep 24, 2009 175 pounds
048-2009, Cascioppo Sausage Brand Products (undeclared allergens) En Español PDF

Sep 11, 2009 175 pounds
046-2009, Big Boy Food Group Ready-To-Eat Meal Kits (Listeria) En Español PDF

Sep 1,
2009 38,782 pounds
045-2009, Smoked Beef Brisket Product (Listeria) En Español PDF

Aug 24, 2009 155 pounds
044-2009, Kraft Foods Pepperoni & Sausage Pizzas (undeclared allergen, soy) En Español PDF

Aug 17, 2009 4,605 pounds
043-2009, Marcacci Meats Ground Beef Products (E. coli O157:H7) En Español PDF

Aug 17, 2009 0 pounds
042-2009, Sterling Pacific Meat Co. Ground Beef Products (E. coli O157:H7) En Español PDF

Aug 13, 2009 0 pounds
040-2009, Camacho's Foods Pork Skin Products (produced without inspection) En Español PDF

Jul 29, 2009 14 pounds
039-2009, King Soopers, Inc. Ground Beef Products (Salmonella) En Español PDF

Jul 22, 2009 119,132 pounds
037-2009, Traditions Pre-Packaged Meal Products (Salmonella) En Español PDF

Jul 1, 2009 71,004 pounds
036-2009, Frozen Meat and Poultry Products - Perogies (unapproved ingredient) En Español PDF

Jun 30, 2009 6,235 pounds
035-2009, Sausage Product (undercooked) En Español PDF

Jun 24, 2009 278 pounds
032-2009, Buffalo Style Chicken Wings (undeclared allergen) En Español PDF

Jun 10, 2009 235,048 pounds
029-2009, Cameco, Inc. Ready-to-Eat Meat and Poultry Products, various (underprocessing) En Español PDF

Jun 5, 2009 79,312 pounds
028-2009, Duck Leg Confit; Hungarian Brand Kolbase (Listeria) En Español PDF

Jun 3, 2009 274 pounds
027-2009, SP Provisions Ground Beef Products (E. coli O157:H7) En Español PDF

Jun 2, 2009 1,537 pounds
026-2009, Brushy Creek Chili no beans (mislabeling)

Jun 2, 2009 6,764 pounds
024-2009, Beef Products (not presented for reinspection)

May 26, 2009 783,424 pounds
023-2009, Paisano Meat Beef and Pork Products (undeclared sulfites) En Español PDF

May 22, 2009 10,427 pounds
021-2009, Bulk Frozen Pork Sausage Products (undeclared allergen) En Español PDF

May 14, 2009 15 pounds
020-2009, AMIGO'S Home Style PORK Tamales Wrapped in Corn Husk (undeclared allergen) En Español PDF

May 14, 2009 3,600 pounds
R01-2009, Bob's Food City Ground Beef Products (E. coli O157:H7) En Español PDF

May 12, 2009 68 pounds
019-2009, A & G Brand Ground Beef Products (E. coli O157:H7) En Español PDF

May 4, 2009 995 pounds
017-2009, Frozen Meat and Poultry Pasta Products (adulterated and misbranded) En Español PDF

Apr 26, 2009 30,973 pounds
016-2009, Ivar's Soup, Turkey Flavored Egg Noodle Soup Base with Turkey Meat (undeclared allergen) En Español PDF

Apr 17, 2009 4,548 pounds
015-2009, Frozen Chicken Products (Salmonella) En Español PDF

Apr 4, 2009 2,780 pounds
012-2009, Ball Park Brand Beef Franks (mislabeling / allergen) En Español PDF

Mar 25, 2009 300 pounds
011-2009, Aidells Smoked Chicken Sausage with Mango and Jalapeño Pepper (mislabeling) En Español PDF

Mar 24, 2009 0 pounds
008-2009, Trader Joe's Chile Lime Chicken Burgers (foreign material) En Español PDF

Feb 27, 2009 312 pounds
007-2009, Weis Simply Delicious Chicken Cordon Bleu (undeclared allergen) En Español PDF

Feb 27, 2009 238 pounds
006-2009, Wei-Chuan USA Granulated Chicken Bouillon Products (ineligible for import) En Español PDF

Feb 24, 2009 54,135 pounds
005-2009, Alaska Sausage Co. Sausage Products (Listeria) En Español PDF

Feb 6, 2009 724 pounds
004-2009, Hain Celestial Group Frozen Chicken Products (Salmonella) En Español PDF

Feb 4, 2009 63,472 pounds
003-2009, Whitey's™ Frozen, Chili Beef Products (foreign material) En Español PDF

Jan 30, 2009 135,900 pounds
002-2009, Barber Foods Frozen, Stuffed Chicken Products (foreign material) En Español PDF

Jan 20, 2009 3,492 pounds
001-2009, Patrick Cudahy Bacon Bit Products (Listeria) En Español PDF

Jan 3, 2009 680 pounds

USA RECALLS

http://www.fsis.usda.gov/Fsis_Recalls/Recall_Case_Archive/index.asp

http://www.fsis.usda.gov/Fsis_Recalls/Open_Federal_Cases/index.asp

Quantity Recovered

http://www.fsis.usda.gov/Fsis_Recalls/Quantity_Recovered/index.asp

>>> Sen. Dianne Feinstein (D-Calif.) announced Monday she has introduced legislation that would amend USDA inspection rules to mandate pathogen treatment and expand labeling requirements on meat and poultry. <<<

>>> The bill would amend the Poultry Products Inspection Act, the Federal Meat Inspection Act and the Federal Food, Drug and Cosmetic Act to prohibit the sale of any processed poultry, meat and FDA-regulated food that has not either undergone a pathogen reduction treatment, or been certified to contain no verifiable traces of pathogens. <<<

IMPOSSIBLE! it sounds good. NEWS FLASH though, and speaking of pathogens, it does nothing for Transmissible Spongiform Encephalopathy. you cannot trace it (will not), you cannot kill it, you can only hide from it for so long, it knows no borders, it knows no boundries, and for those that consume it and become clinical (I know what the human numbers show to date), it is 100% fatal in man and animal. But with the bogus UKBSEnvCJD only theory, the ignorance and denial of the 'pass it forward' and 'friendly fire' modes of transmission there from, proven, the lack of surveillance for those victims there from, an incubation periods from years, to decades even, the infamous BSE MRR, the legal trading of all strains of TSE globally, just for a buck, who cares$ right? not enough _documented_ body bags yet, traceable. trade, trade, trade$ We have had food safety rules on the books for decades, BSE feed bans, but if you don't follow the existing rules and regulations, how on earth are you going to follow new rules and regulations? you will not, and irradiation to me, my opinion, your just masking the shit. and it will get deeper with irradiation. it may be irradiated, but shit is shit to me, and why then go through the trouble of disinfection procedures, etc.? it will be irradiated and all is well...not...you cannot irradiate the PrPeriod. ...TSS

In addition to brain homogenates, we performed bioassays using irradiated faecal homogenates collected from infected mule deer by intracerebral inoculation into Tg(ElkPrP) mice. Irradiation was used to damage nucleic acids and inactivate bacteria and viruses with minimal effects on prion titres23; irradiation of the Elk1 CWD isolate did not diminish its titre when assayed in Tg(ElkPrP) mice (data not shown).

http://wfs.sdstate.edu/wfsdept/courses/WL%20425-525/Tamguney%20et%20al%20%202009%20Nature%20-%20CWD.pdf

Purified scrapie prions resist inactivation by UV irradiation.

C Bellinger-Kawahara, J E Cleaver, T O Diener, and S B Prusiner

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC255227/

>>>In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — at the average rate of one every six weeks...<<<

http://downercattle.blogspot.com/2009/09/suit-meatpacker-used-downer-cows-for-4.html

do you actually believe all these schools recalled this meat because of a few cattle being abused,

see list ; FNS All Regions Affected School Food Authorities By State United States Department of Agriculture Food and Nutrition Service National School Lunch Program March 24, 2008 School Food Authorities Affected by Hallmark/Westland Meat Packing Co. Beef Recall February 2006 - February 2008

http://www.fns.usda.gov/fns/safety/Hallmark-Westland_byState.pdf

well, i will try again, go to this site ;

http://www.fns.usda.gov/fns/

left hand corner search ; Hallmark/Westland Meat Packing Co. Beef Recall your should get this ;

http://65.216.150.153/texis/search?pr=FNS

1 through 1 of 1 matching documents, best matches first. sort by date 1: Hallmark - Westland SFA Reporting by State - 3-24-2008.xls Lunch Program March 24, 2008 School Food Authorities Affected by Hallmark/Westland Meat Packing Co. Beef Recall February 2006 - February 2008 The U.S. Department of Agriculture ...

http://www.fns.usda.gov/...ety/Hallmark-Westland_byState.pdf

I have tried to get these papers through the court, but no luck. they want me to pay to retrieve the papers, and i am not going to pay for something I know happened. about like the last two FOIA on suspect mad cow feed going into commerce in the USA in 2009. I knew it had, but wanted them to say it. and they finally did via the FOIA. Members of The HSUS are also concerned about the meat products provided to their children through the National School Lunch Program. More than 31 million school children receive lunches through the program each school day. To assist states in providing healthful, low-cost or free meals, USDA provides states with various commodities including ground beef. As evidenced by the HallmarkNVestland investigation and recall, the potential for downed animals to make their way into the National School Lunch Program is neither speculative nor hypothetical.

http://biotech.law.lsu.edu/cases/FDA/hsus-v-schafer-usda-complaint.pdf

Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME. snip... The rancher was a ''dead stock'' feeder using mostly (>95%) downer or dead dairy cattle...

http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf

Friday, September 4, 2009

FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009

http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html

Saturday, August 29, 2009

FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html

----- Original Message ----- From: "Terry S. Singeltary Sr." To: Sent: Thursday, November 05, 2009 9:25 PM Subject: [BSE-L] re-FOIA REQUEST ON FEED RECALL PRODUCT contaminated with prohibited material Recall # V-258-2009 and Recall # V-256-2009

CONFIRMED BSE MAD COW RELATED FEED BAN RECALLS

http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html

PLEASE be aware, for 4 years, the USDA fed our children all across the Nation dead stock downer cows, the most high risk cattle for BSE aka mad cow disease and other dangerous pathogens. who will watch our children for CJD for the next 5+ decades ???

SCHOOL LUNCH PROGRAM FROM DOWNER CATTLE UPDATE

http://downercattle.blogspot.com/2009/05/who-will-watch-children.html

http://downercattle.blogspot.com/

Tuesday, November 17, 2009

SEAC EFFECT OF AGE ON THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM
ENCEPHALOPATHIES SEAC 103/2

http://downercattle.blogspot.com/2009/11/seac-effect-of-age-on-pathogenesis-of.html

Tuesday, November 17, 2009

SEAC NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS (IBNC) FROM THE VETERINARY LABORATORIES AGENCY (VLA) SEAC 103/1

http://bse-atypical.blogspot.com/2009/11/seac-new-results-on-idiopathic.html

Sunday, September 6, 2009

MAD COW USA 1997 SECRET VIDEO

SEE ANOTHER VIDEO THAT SHOWED IN CANADA, BUT NOT USA, ABOUT ANOTHER USA TSE COVER-UP MORE BRAINS NOT TESTED PROPERLY, key brain parts missing. ...

http://madcowusda.blogspot.com/2009/09/mad-cow-usa-1997-video.html

SEE THIS DAMNING VIDEO AT BOTTOM OF ;

Monday, July 27, 2009

U.S.A. HIDING MAD COW DISEASE VICTIMS AS SPORADIC CJD ?

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON PRIONS SPEAKING ABOUT ANN VENEMAN

''nobody has ever ask''

''they dont want our comment''

''they don't want to know, the don't care''

''i have tried repeatedly''

''level of absolute ignorance''

''Entire policy was driven...heard from mr. laycraft, so now, after time has passed, it's ok for Canada, cattle under 30 month, to the USA, THAT'S ALL THAT MATTERED!

PRUSINER ASKED : IF FROM YOUR TESTIMONY, A DEMONSTRATED THREAT TO PUBLIC HEATH ?

''yes, i think prions are bad to eat, and you can die from them''

http://maddeer.org/video/embedded/prusinerclip.html

2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006

http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html

Monday, November 16, 2009

CANADA, USA, specified risk materials (SRMs), Environment, Fertilizer, AND Politics, just more BSe

http://madcowspontaneousnot.blogspot.com/2009/11/canada-usa-specified-risk-materials.html

Thursday, November 05, 2009

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with
mixed phenotype and co-occurrence of PrPSc types: an updated classification

http://creutzfeldt-jakob-disease.blogspot.com/2009/11/incidence-and-spectrum-of-sporadic.html

Sunday, August 10, 2008

A New Prionopathy OR more of the same old BSe and sporadic CJD

http://creutzfeldt-jakob-disease.blogspot.com/2008/08/new-prionopathy-or-more-of-same-old-bse.html

Monday, October 26, 2009

MAD COW DISEASE, AND U.S. BEEF TRADE

MAD COW DISEASE, CJD, TSE, SOUND SCIENCE, COMMERCE, AND SELLING YOUR SOUL TO THE DEVIL

http://usdameatexport.blogspot.com/2009/10/mad-cow-disease-and-us-beef-trade.html

IN A NUT SHELL ;

(Adopted by the International Committee of the OIE on 23 May 2006)

11. Information published by the OIE is derived from appropriate declarations made by the official Veterinary Services of Member Countries. The OIE is not responsible for inaccurate publication of country disease status based on inaccurate information or changes in epidemiological status or other significant events that were not promptly reported to the Central Bureau,

http://www.oie.int/eng/Session2007/RF2006.pdf

Docket APHIS-2006-0026 Docket Title Bovine Spongiform Encephalopathy; Animal Identification and Importation of Commodities Docket Type Rulemaking Document APHIS-2006-0026-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions, Identification of Ruminants and Processing and Importation of Commodities Public Submission APHIS-2006-0026-0012 Public Submission Title Comment from Terry S Singletary

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801e47e1

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028 Public Submission Title Comment from Terry S Singletary

Comment 2006-2007 USA AND OIE POISONING GLOBE WITH BSE MRR POLICY

THE USA is in a most unique situation, one of unknown circumstances with human and animal TSE. THE USA has the most documented TSE in different species to date, with substrains growing in those species (BSE/BASE in cattle and CWD in deer and elk, there is evidence here with different strains), and we know that sheep scrapie has over 20 strains of the typical scrapie with atypical scrapie documented and also BSE is very likely to have passed to sheep. all of which have been rendered and fed back to animals for human and animal consumption, a frightening scenario. WE do not know the outcome, and to play with human life around the globe with the very likely TSE tainted products from the USA, in my opinion is like playing Russian roulette, of long duration, with potential long and enduring consequences, of which once done, cannot be undone. These are the facts as I have come to know through daily and extensive research of TSE over 9 years, since 12/14/97. I do not pretend to have all the answers, but i do know to continue to believe in the ukbsenvcjd only theory of transmission to humans of only this one strain from only this one TSE from only this one part of the globe, will only lead to further failures, and needless exposure to humans from all strains of TSE, and possibly many more needless deaths from TSE via a multitude of proven routes and sources via many studies with primates and rodents and other species.

MY personal belief, since you ask, is that not only the Canadian border, but the USA border, and the Mexican border should be sealed up tighter than a drum for exporting there TSE tainted products, until a validated, 100% sensitive test is available, and all animals for human and animal consumption are tested. all we are doing is the exact same thing the UK did with there mad cow poisoning when they exported it all over the globe, all the while knowing what they were doing. this BSE MRR policy is nothing more than a legal tool to do just exactly what the UK did, thanks to the OIE and GW, it's legal now. and they executed Saddam for poisoning ???

go figure. ...

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8151

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028.1 Public Submission Title Attachment to Singletary comment

January 28, 2007

Greetings APHIS,

I would kindly like to submit the following to ;

BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01

http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f8152&disposition=attachment&contentType=msw8

Monday, November 30, 2009

USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE

http://nor-98.blogspot.com/2009/11/usda-and-oie-collaborate-to-exclude.html

Monday, November 23, 2009

BSE GBR RISK ASSESSMENTS UPDATE NOVEMBER 23, 2009 COMMISSION OF THE EUROPEAN COMMUNITIES AND O.I.E.

http://docket-aphis-2006-0041.blogspot.com/2009/11/bse-gbr-risk-assessments-update.html

Wednesday, November 18, 2009

R-CALF: 40 Groups Disagree With USDA's Latest BSE Court Submission

http://bse-atypical.blogspot.com/2009/11/r-calf-40-groups-disagree-with-usdas.html

Tuesday, November 10, 2009

Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan and USA

http://usdavskorea.blogspot.com/2009/11/surveillance-on-bovine-spongiform.html

Monday, November 30, 2009

Taiwan, USDA, and USA beef, what the consumer does not know, could kill them

http://usdavskorea.blogspot.com/2009/11/taiwan-usda-and-usa-beef-what-consumer.html

Thursday, November 12, 2009

BSE FEED RECALL Misbranding of product by partial label removal to hide original source of materials 2009

http://madcowfeed.blogspot.com/2009/11/bse-feed-recall-misbranding-of-product.html

http://madcowtesting.blogspot.com/

HUMAN and ANIMAL TSE Classifications i.e. mad cow disease and the UKBSEnvCJD only theory

http://www.regulations.gov/search/Regs/contentStreamer?objectId=090000648027c28e&disposition=attachment&contentType=pdf

BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA

http://madcowtesting.blogspot.com/

Monday, December 21, 2009

Distinct Molecular Signature of Bovine Spongiform Encephalopathy Prion in Pigs

http://madporcinedisease.blogspot.com/2009/12/distinct-molecular-signature-of-bovine.html

Monday, December 14, 2009

Similarities between Forms of Sheep Scrapie and Creutzfeldt-Jakob Disease Are Encoded by Distinct Prion Types

http://nor-98.blogspot.com/2009/12/similarities-between-forms-of-sheep.html

Saturday, December 05, 2009

Molecular Model of Prion Transmission to Humans

http://creutzfeldt-jakob-disease.blogspot.com/2009/12/molecular-model-of-prion-transmission.html

Tuesday, August 11, 2009

Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants

http://creutzfeldt-jakob-disease.blogspot.com/2009/08/characteristics-of-established-and.html

Friday, December 11, 2009

Sporadic Creutzfeldt-Jakob disease causing a 2-years slowly progressive isolated dementia

http://creutzfeldt-jakob-disease.blogspot.com/2009/12/sporadic-creutzfeldt-jakob-disease.html

Sunday, August 09, 2009

CJD...Straight talk with...James Ironside...and...Terry Singeltary... 2009

http://creutzfeldt-jakob-disease.blogspot.com/2009/08/cjdstraight-talk-withjames.html

Saturday, June 13, 2009

Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009

http://cjdusa.blogspot.com/2009/06/monitoring-occurrence-of-emerging-forms.html

Thursday, December 17, 2009

An Unusual Case of Variant CJD 18 December 2009

http://creutzfeldt-jakob-disease.blogspot.com/2009/12/unusual-case-of-variant-cjd-18-december.html

You may see all my blogs under the following different topics ;

http://www.blogger.com/profile/06986622967539963260

TSS

stupid is, as stupid does. ...Forest Gump

Taiwan, USDA, and USA beef, what the consumer does not know, could kill them

2009-11-30T09:42:00.000-08:00

The beef referendum is necessary

By Yu Ying-fu

Monday, Nov 30, 2009, Page 8 A referendum proposal on US beef launched by civic groups including the Consumers’ Foundation, the Homemakers’ Union and Foundation, the John Tung Foundation and the National Health Insurance Surveillance Alliance has passed the first application threshold and is proceeding to the second stage.

The proposed referendum suggests rejecting the Department of Health’s decision to allow imports of US bone-in beef, ground beef, bovine internal organs, spinal cord, etc, starting today. It further seeks to reopen negotiations with the US over beef imports.

For the referendum application to proceed, its proponents must collect the signatures of 5 percent of the total number of people who were eligible to vote in the most recent presidential election.

Gathering the signatures of hundreds of thousands of people across the country is no simple feat. As a lawyer, I have experience handling consumer complaints, for example against the Taipei City Government’s bus office and Eastern Multimedia Group.

I helped distribute official signature forms for the present proposal for a referendum on US beef. But based on my past experience, I am concerned that the signature drive will fail.

The proposed referendum says that the protocol on US beef imports signed by Taiwan and the US in Washington on Oct. 22 allows imports of bone-in beef, ground beef, processed beef products not contaminated with specific risk materials, central nervous system parts and meat scraps stripped by machine from cows less than 30 months old.

This deal sparked fear among consumers, while pan-blue and pan-green politicians have opposed the protocol, as have several county and city governments.

The government’s decision to relax restrictions on the import of bone-in beef, internal organs and other beef products from the US despite documented cases of bovine spongiform encephalopathy (BSE, also called mad cow disease) there — and political meddling by the government and the National Security Council in the decisions of experts at the health department are not appropriate in a democracy.

Taiwan’s Centers for Disease Control (CDC) say that treatment for variant Creutzfeldt-Jakob disease (vCJD), which is caused by abnormal prions from infected meat, cannot be cured. There is no treatment to slow or halt the course of the disease. Anyone infected with vCJD is on the road to inevitable death.

The only way to be sure of not getting the illness is to avoid eating beef products from BSE-affected countries.

To this day there have been no cases of the abnormal prion in Taiwan. Once in Taiwan, however, how would Taiwan get rid of it?

The government insists that US bone-in beef is safe, yet when the Ministry of Audit delivered a report on Oct. 27 to the legislature on the central government’s final account for last year, Auditor-General Lin Ching-long (???) said that, as of last year, the health department did not have enough personnel, funding or equipment to inspect and test US beef imports.

Furthermore, the prion can escape detection by specialized tests. This is because concentrations of the prion in certain body parts are so low that no technology exists that can guarantee that meat is free of it.

The prion’s presence can only be detected within six months of the onset of BSE. Cows less than 30 months old may be in the incubation stage of the illness, making the prion undetectable.

Health authorities have no way of guaranteeing that US beef is free of the disease, so assurances that consumers will be protected are nothing but empty talk.

Since the government is not capable of effectively testing imported beef, it should not have relaxed restrictions. Doing so puts consumers at risk.

This is a matter of consumer rights and a question of life or death for us and for future generations.

If not enough people sign the petition for this referendum proposal, Taiwan will be an object of disdain for the South Koreans. At least the South Koreans took to the streets in the hundreds of thousands to fight imports of US beef.

Yu Ying-fu is a lawyer.

TRANSLATED BY JULIAN CLEGG

http://www.taipeitimes.com/News/editorials/archives/2009/11/30/2003459764

Taiwan - Inquiry into US beef imports 30 Nov 2009

Premier Wu Den-yih (???) yesterday called for “mutual respect” between Taiwan and the US, as Taipei moved to adopt measures to block imports of US ground beef and bovine offal.

Wu dismissed remarks made by American Institute in Taiwan (AIT) Chairman Raymond Burghardt when he met with Legislative Speaker Wang Jyn-ping (???) on Monday that the controversy surrounding Taiwan’s relaxation of US beef imports was a “phony issue,” saying it was a “real issue of concern to the public.”

“We respect what [Burghardt] said, but we think and feel differently about this issue as he is an American and from a beef-exporting country,” Wu told reporters at the Executive Yuan.

“When people still have doubts over the safety of US ground beef and bovine offal, of course the government has to prohibit imports of such products,” Wu said. “We respect [Burghardt’s] views, and we hope he can understand the public sentiment.”

Taiwan recently signed a protocol with the US to expand market access for US beef to include bone-in beef and other beef products that have not been contaminated with “specific risk materials.”

OUTCRY

In response to a public outcry, the government promised to adopt administrative means to block ground beef and bovine offal, a move supported by the Chinese Nationalist Party (KMT) lawmakers, but a stance that has put them at odds with their Democratic Progressive Party (DPP) counterparts, who have proposed amending the Act Governing Food Sanitation (???????) to statutorily ban the imports.

Wu said the KMT’s version of the amendments — requiring all imports of ground beef and intestines be thawed for examination in a way that will effectively destroy the products — could create a win-win-win situation to safeguard public health, conform to the spirit of the WTO and respect the Taiwan-US protocol.

“I think there would be no reason for the US to oppose [administrative measures] targeting ground beef and bovine offal, which account for between 1 and 3 percent of its exports, nor would it let [the controversy] pose a negative influence on imports of its bone-in beef into Taiwan,” the premier said.

‘RISKY’ PRODUCTS

Meanwhile, Legislative Speaker Wang Jin-pyng (???) said yesterday it was unlikely the legislature would deal with a number of proposed amendments to the Act Governing Food Sanitation seeking to ban “risky” beef products from the US before the local elections next Saturday.

“We can sit down and discuss the proposals after the elections or the legislature will be paralyzed as a result,” Wang told reporters.

Wang made the remarks after the DPP once again occupied the speaker’s podium and threatened to boycott plenary sessions through next Saturday.

PARALYZED

The DPP has paralyzed the plenary session since Nov. 3, making it impossible for any bills to clear the legislative floor over the past three weeks.

By law, the legislature should review and pass the central government’s fiscal budget request by the end of next month.

The deadlock continued because the DPP and the KMT still could not agree on the wording of the proposals.

The DPP would like to enshrine a ban on “risky” US beef products in the law, while the KMT wants to authorize the government to draw up measures to inspect bovine products from places where the risk of mad cow disease has been under control.

The KMT caucus condemned the DPP for paralyzing the plenary session again.

At a press conference, KMT caucus whip Lin Yi-shih (???) accused the DPP of refusing to negotiate relevant proposals even if the KMT had proposed a week ago to “ban the import of beef materials or products that are found risky or inedible.”

Showing reporters a number of snapshots of yesterday morning’s plenary session, KMT caucus secretary-general Lu Hsueh-chang (???) said only three DPP legislators — Chai Trong-rong (???), Yeh Yi-jin (???) and Kuo Wen-cheng (???) — participated in the boycott, while the remaining 25 DPP lawmakers were absent.

Lu accused the DPP of manipulating the controversy for political gain in the elections.

Meanwhile, KMT Legislator Kung Wen-chi (???) alleged that the DPP mobilized supporters to paralyze his phone lines in protest against his proposed amendment to the act.

Kung’s proposal sought to “draw up measures to inspect beef products from areas where the risk of mad cow disease has been under control.”

Kung said his cellphone and the phone at his office had been paralyzed by angry callers since an anonymous Netizen posted an article on Coolloud — a Web site for civic groups to publicize press releases and press conference notices — calling on the public to call the 22 KMT legislators endorsing Kung’s proposal.

Meanwhile, Taiwan Solidarity Union (TSU) Chairman Huang Kun-huei (???) said yesterday that Burghardt could not be more erroneous on the safety of US beef, demanding the US envoy recant his statement that US beef was safe for human consumption.

“It is possible that because Burghardt does not live on the continental US, he has lost touch with the current situation [of beef safety] and needs to be taught a lesson,” Huang said.

The TSU said the Consumer Union — a US-based consumer protection foundation — is engaged in a dispute with the US Food and Drug Administration (FDA), arguing that the US private meat plants should be allowed to conduct their own tests on cattle for bovine spongiform encephalopathy (BSE).

Huang said that the Consumer Union has long questioned the safety of US beef because of the prevalent practice of using chicken excrement as part of cow feed.

Such a practice has been blamed for being a source of BSE and other neurological diseases found in US cattle, Huang said.

Although the Consumer Union has formally asked the FDA to allow private meat establishments to conduct their own BSE tests, which the TSU said would only cost US$0.10 per test, the US government has flatly refused to do so, he said.

“Burghardt was obviously dead wrong when he said US beef is safe for human consumption and that no one in the US worries about its safety. He must recant his statement because, Mr Burghardt, you are wrong,” Huang said.

Source: taipeitimes

http://www.meattradenewsdaily.co.uk/news/301109/taiwan___inquiry_into_us_beef_imports.aspx

'Flash mob' US beef protest held outside Presidential Office

BLOGGERS WITH A BEEF: Protesters said it was the beginning of a campaign in which they hoped to stage a daily 'flash mob' protest at MRT stations By Ko Shu-ling STAFF REPORTER Monday, Nov 30, 2009, Page 3 A small group of bloggers and Internet users staged a “flash mob” protest in front of the Presidential Office yesterday afternoon to oppose the government’s decision to relax restrictions on US bone-in beef and beef products.

Chen Tai-yuan (???), who led the nine-strong protest, said yesterday was just the beginning of a long campaign and they hoped to stage at least one flash mob protest a day at mass rapid transit system (MRT) stations. Videos of the protests would be posted on YouTube, he said.

Chanting “Oppose toxic beef! Just say no! Relaunch negotiations,” participants in black lay on the ground for two minutes playing dead. They staged two protests, an hour apart.

Chen said they wore black to signify a funeral for President Ma Ying-jeou (???) and his administration, which he said had failed to protect the health of the public.

“Vegetarians can get mad cow disease,” he said. “There is a proven case in India.”

While the administration has reassured the public on the safety of US bone-in beef and beef products, Chen said he was not convinced.

“If it is safe, why did Taichung Mayor Jason Hu (???) say he would only eat US beef if President Ma eats it,” he said.

When asked whether he would eat US beef if Ma ate it in public to vouch for its safety, Chen said if Ma was willing to risk his own life that was his business.

Chen said he looked at the matter from two perspectives. One was whether US beef was safe and the other was how the administration had conducted its negotiations with Washington.

On the safety of US beef, Chen said Japan had sent food safety experts to the US to examine the slaughter of cattle younger than 20 months old and the expenses had been paid for by the US government. Taiwan, on the other hand, was conducting random checks at its own expense.

“Why? Are we second-class citizens or something?” he said. “Where is our dignity?”

Participants in yesterday’s protest said they supported the cause, but did not want their faces to be seen.

An 18-year-old who covered his face with a denim jacket said media exposure would not be good for his modeling career. Another participant wearing a surgical mask, black sunglasses and a baseball cap said he was not a supporter of the Democratic Progressive Party, but he believed in the ban on US bone-in beef. His position, however, ran counter to that of his company, a TV station.

Peng Lung-san (???), a motor scooter mechanic, lamented the fact that ordinary people were powerless, saying the government did whatever it wanted in its own interests.

Speaking from his own experience, Peng said the Taipei City Government had turned a deaf ear to his pleas not to demolish his apartment to make way for a new, bigger building complex. He said the city approved of such projects under the pretext of “urban planning.”

http://www.taipeitimes.com/News/taiwan/archives/2009/11/30/2003459780

Greetings,

I would like comment on the facts about USA and BSE and CJD aka mad cow disease, and the rights of the Honorable People of Taiwan and all consumers. This same old song and dance has been played out time and time again, if it not be Taiwan, it was Korea, if not Korea, it was Japan, Canada, ... etc. etc.

It's all about only one thing, TRADE! Science has nothing to do with it. When the BSE GBR risk assessments and trade there from was abolished, when the OIE and the USDA made legal the trading of all strains of TSE globally, the consumer lost. AS with just what happened recently with the atypical Scrapie NOR-98, USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 FROM THE ANIMAL HEALTH CODE. IT can be traded freely now. AS with the atypical BSE cases in the USA, USDA et al have twisted this too into nothing more than an old cow prion disease, not to worry, with the cart before the horse again. When in fact atypical BSE seems to be more virulent than the typical BSE, with both the atypical l-BSE and h-BSE and the typical c-BSE, all documented in North America. The USA has systematically tried to cover up all cases of mad cow disease in the USA, but they failed to do it. A few were accidently reported, and then only with an act of Congress, were they confirmed. IF not for the OIG and the Honorable Phyllis Fong, that mad cow in Texas (the second one, the first stumbling and staggering mad cow in Texas in 2001 they refused to test at all, and sent it to be rendered), that 2nd Texas mad cow would have never been confirmed. The way it was, it took 7 months and literally an act of Congress to confirm it. Then the Alabama mad cow showed up. There is a long line of mad cow cover ups in the USA. They have been documented and ignored. The thing about Transmissible Spongiform Encephalopathy, it's the long, very long incubation period from time of exposure, to clinical symptoms, and then to death, for the ones that do become clinically affected, death is absolute, it is 100% fatal. But for some, they become exposed, and never go clinical. It is a false sense of security, that left unchecked, could come back to haunt the world. Most every scientist around the Globe knows full well that the USA Enhanced BSE surveillance program of 2004, and the Harvard BSE Risk Assessment of BSE in the USA, both were terribly flawed, and proven to be so. There is no doubt that the total of some 800,000+ BSE test were meaningless, due to these flaws, and proven to be so. The August 4, 1997 partial and voluntary mad cow feed ban in the USA was also terribly flawed, and proven to be so. For Pete's sake were are still feeding cows to cows in the USA in 2009. THE USDA et al let our children for 4 years feed on dead stock downer cows through the school lunch program, the most high risk cattle for mad cow disease. WHO will watch the children for the next 5+ decades for CJD. Sporadic CJD has been on the rise year and year in the USA, from 28 in 1996 and earlier to 205 cases in 2008, which includes 38 cases with type determination pending in which the diagnosis of vCJD has been excluded. nvCJD (which is vCJD now), is human BSE i.e. nvCJD from UK cattle. When UK sheep scrapie was transmitted to UK cattle, typical c-BSE was born, and nvCJD to humans there from. HOWEVER, when USA sheep scrapie was transmitted to USA cattle, your typical UK c-BSE was not the outcome, but something pathologically different. SO, Confucius ask, why then would USA human mad cow, look like UK nvCJD. It would NOT. There are many strains of scrapie, some 20+ different strains, with the atypical scrapie (NOR-98), and BSE in sheep. with the recent decisions of the OIE and the USDA et al on Nor-98, and deregulating that TSE, simply for trade, is like putting the horse before the cart, because they do not have the science to date to validate this human gamble. TYPICAL scrapie transmits to primate by their non-force oral consumption. TO my knowledge, to date, there have been no oral transmission studies done on atypical Scrapie NOR-98. WHAT about CWD? very little is known about CWD in the USA. now, there are two documented strains of CWD in cervids. CWD transmits to primates. WHAT about TME i.e. mad mink disease also in the USA? all these TSE have been rendered and fed to animals for human and animal consumption for over a decade. sporadic CJD rising in the USA of unknown route and sou ce. sporadic CJD in young and old people in the USA. I don't pretend to have all the answers, but I do know one thing, we have floundered way too long, and too export these TSE around the globe is just damn wrong in my opinion, and the consumers of these Countries receiving our highly potentially tainted products must have all the facts, not just part of them. WE must not allow the OIE and the USDA do what the U.K. did, that is export their tainted mad cow products around the Globe, except this time they just made it legal. There is much more to this nightmare than just the oral consumption, we must think 'friendly fire' there from. ...TSS

>>> In the papers, the government alleges the meatpacking plant slaughtered and processed downer cows for nearly four years — from January 2004 to September 2007 — at the average rate of one every six weeks...<<<

http://downercattle.blogspot.com/2009/09/suit-meatpacker-used-downer-cows-for-4.html

do you actually believe all these schools recalled this meat because of a few cattle being abused ?

see list ;

FNS All Regions Affected School Food Authorities By State United States Department of Agriculture Food and Nutrition Service National School Lunch Program March 24, 2008 School Food Authorities Affected by Hallmark/Westland Meat Packing Co. Beef Recall February 2006 - February 2008

http://www.fns.usda.gov/fns/safety/Hallmark-Westland_byState.pdf

Members of The HSUS are also concerned about the meat products provided to their children through the National School Lunch Program. More than 31 million school children receive lunches through the program each school day. To assist states in providing healthful, low-cost or free meals, USDA provides states with various commodities including ground beef. As evidenced by the HallmarkNVestland investigation and recall, the potential for downed animals to make their way into the National School Lunch Program is neither speculative nor hypothetical.

http://biotech.law.lsu.edu/cases/FDA/hsus-v-schafer-usda-complaint.pdf

PLEASE SEE ;

Over the next 8-10 weeks, approximately 40% of all the adult mink on the farm died from TME.

snip...

95%) downer or dead dairy cattle and a few horses. Sheep had never been fed.

snip...

We believe that these findings may indicate the presence of a previously unrecognized scrapie-like disease in cattle and wish to alert dairy practitioners to this possibility.

snip...

PROCEEDINGS OF THE SEVENTH ANNUAL WESTERN CONFERENCE FOR FOOD ANIMAL VETERINARY MEDICINE, University of Arizona, March 17-19, 1986

http://web.archive.org/web/20030331063559/http://www.bseinquiry.gov.uk/files/mb/m09a/tab01.pdf

http://web.archive.org/web/20030516051623/http://www.bseinquiry.gov.uk/files/mb/m09/tab05.pdf

IN CONFIDENCE PERCEPTIONS OF UNCONVENTIONAL SLOW VIRUS DISEASES OF ANIMALS IN THE USA

http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf

3.56 A further difference in the transmission properties of the two diseases was the pattern of disease caused in the brains of experimental animals. Mice inoculated with scrapie material from geographically and temporally distinct sources were found to have variable brain lesions, whereas mice inoculated with BSE material similarly derived from different sources all had very similar patterns of disease. 30 These results showed that, unlike scrapie, only one strain of BSE was present in the inocula derived from different sources. As the current hypothesis suggested that scrapie had transmitted to cattle at a number of geographically separate sites, it might have been expected that several strains of BSE would have been evident, given that over 20 strains of scrapie were known. Since 1996, strain-typing studies in mice have shown that the lesion profile produced by BSE is different to all known scrapie strains. 31

3.57 The experiment which might have determined whether BSE and scrapie were caused by the same agent (ie, the feeding of natural scrapie to cattle) was never undertaken in the UK. It was, however, performed in the USA in 1979, when it was shown that cattle inoculated with the scrapie agent endemic in the flock of Suffolk sheep at the United States Department of Agriculture in Mission, Texas, developed a TSE quite unlike BSE. 32 The findings of the initial transmission, though not of the clinical or neurohistological examination, were communicated in October 1988 to Dr Watson, Director of the CVL, following a visit by Dr Wrathall, one of the project leaders in the Pathology Department of the CVL, to the United States Department of Agriculture. 33 The results were not published at this point, since the attempted transmission to mice from the experimental cow brain had been inconclusive. The results of the clinical and histological differences between scrapie-affected sheep and cattle were published in 1995. Similar studies in which cattle were inoculated intracerebrally with scrapie inocula derived from a number of scrapie-affected sheep of different breeds and from different States, were carried out at the US National Animal Disease Centre. 34 The results, published in 1994, showed that this source of scrapie agent, though pathogenic for cattle, did not produce the same clinical signs of brain lesions characteristic of BSE.

3.58 There are several possible reasons why the experiment was not performed in the UK. It had been recommended by Sir Richard Southwood (Chairman of the Working Party on Bovine Spongiform Encephalopathy) in his letter to the Permanent Secretary of MAFF, Mr (now Sir) Derek Andrews, on 21 June 1988, 35 though it was not specifically recommended in the Working Party Report or indeed in the Tyrrell Committee Report (details of the Southwood Working Party and the Tyrell Committee can be found in vol. 4: The Southwood Working Party, 1988-89 and vol. 11: Scientists after Southwood respectively). The direct inoculation of scrapie into calves was given low priority, because of its high cost and because it was known that it had already taken place in the USA. 36 It was also felt that the results of such an experiment would be hard to interpret. While a negative result would be informative, a positive result would need to demonstrate that when scrapie was transmitted to cattle, the disease which developed in cattle was the same as BSE. 37 Given the large number of strains of scrapie and the possibility that BSE was one of them, it would be necessary to transmit every scrapie strain to cattle separately, to test the hypothesis properly. Such an experiment would be expensive. Secondly, as measures to control the epidemic took hold, the need for the experiment from the policy viewpoint was not considered so urgent. It was felt that the results would be mainly of academic interest. 38 3.59 Nevertheless, from the first demonstration of transmissibility of BSE in 1988, the possibility of differences in the transmission properties of BSE and scrapie was clear. Scrapie was transmissible to hamsters, but by 1988 attempts to transmit BSE to hamsters had failed. Subsequent findings increased that possibility.

http://web.archive.org/web/20010224062436/http://www.bseinquiry.gov.uk/report/volume2/chaptea3.htm#820550

Tuesday, November 17, 2009

SEAC EFFECT OF AGE ON THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES SEAC 103/2 (USDA CERTIFIED DEAD STOCK DOWNER COW SCHOOL LUNCH PROGRAM)

http://downercattle.blogspot.com/2009/11/seac-effect-of-age-on-pathogenesis-of.html

Tuesday, November 17, 2009

SEAC NEW RESULTS ON IDIOPATHIC BRAINSTEM NEURONAL CHROMATOLYSIS (IBNC) FROM THE VETERINARY LABORATORIES AGENCY (VLA) SEAC 103/1

http://bse-atypical.blogspot.com/2009/11/seac-new-results-on-idiopathic.html

2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006

http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html

Monday, October 19, 2009

Atypical BSE, BSE, and other human and animal TSE in North America Update October 2009

http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html

Tuesday, November 10, 2009

Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan and USA

http://usdavskorea.blogspot.com/2009/11/surveillance-on-bovine-spongiform.html

Monday, November 16, 2009

CANADA, USA, specified risk materials (SRMs), Environment, Fertilizer, AND Politics, just more BSe

http://madcowspontaneousnot.blogspot.com/2009/11/canada-usa-specified-risk-materials.html

Friday, September 4, 2009

FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009

http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html

Saturday, August 29, 2009

FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html

----- Original Message ----- From: "Terry S. Singeltary Sr." To: Sent: Thursday, November 05, 2009 9:25 PM Subject: [BSE-L] re-FOIA REQUEST ON FEED RECALL PRODUCT contaminated with prohibited material Recall # V-258-2009 and Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html

MADCOW DISEASE USA SPONTANEOUS OR FEED ?

http://madcowspontaneousnot.blogspot.com/

USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE

OIE Scrapie Chapter Revision • Current draft recognizes Nor98-like scrapie as a separate disease from classical scrapie • USDA provided comments on the draft to OIE

http://www.animalagriculture.org/Solutions/Proceedings/Annual%20Meeting/2009/Sheep%20&%20Goat/Myers,%20Thomas.pdf

Atypical scrapie/Nor 98 October 2009

Last year, after examining member country submissions and investigating rigorous scientific research, the World Organisation for Animal Health (OIE) decided that Nor 98 should not be listed in its Terrestrial Animal Health Code. The Code sets out trade recommendations or restrictions for listed diseases or conditions, and the OIE determined there was no need for such recommendations around Nor 98.

http://www.nzfsa.govt.nz/publications/ce-column/ce-web-nor98.htm

http://www.biosecurity.govt.nz/files/pests/atypical-scrapie/atypical-scrapie-faq-oct09.pdf

Sutton reported that USDA has urged the World Organization for Animal Health (OIE) to categorize Nor98-like scrapie as a separate disease from classical scrapie. Currently, the OIE has proposed a draft revision of their scrapie chapter that would exclude Nor98-like scrapie from the chapter. USDA will be submitting it's comments on this proposal soon.

http://www.ohiosheep.org/Events/ScrapieNewsletterMarch09.pdf

see full text ;

Monday, November 30, 2009

USDA AND OIE COLLABORATE TO EXCLUDE ATYPICAL SCRAPIE NOR-98 ANIMAL HEALTH CODE

http://nor-98.blogspot.com/2009/11/usda-and-oie-collaborate-to-exclude.html

Tuesday, August 04, 2009 Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

http://chronic-wasting-disease.blogspot.com/2009/08/susceptibilities-of-nonhuman-primates.html

Sunday, April 12, 2009

CWD UPDATE Infection Studies in Two Species of Non-Human Primates and one Environmental reservoir infectivity study and evidence of two strains

http://chronic-wasting-disease.blogspot.com/2009/04/cwd-update-infection-studies-in-two.html

Wednesday, March 18, 2009

Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay

http://chronic-wasting-disease.blogspot.com/2009/03/detection-of-cwd-prions-in-urine-and.html

Thursday, July 23, 2009

UW Hospital warning 53 patients about possible exposure to rare brain disease

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/uw-hospital-warning-53-patients-about.html

10.3201/eid1505.081458 Suggested citation for this article: Angers RC, Seward TS, Napier D, Green M, Hoover E, Spraker T, et al. Chronic wasting disease prions in elk antler velvet. Emerg Infect Dis. 2009 May; [Epub ahead of print]

Chronic Wasting Disease Prions in Elk Antler Velvet

http://chronic-wasting-disease.blogspot.com/2009/03/chronic-wasting-disease-prions-in-elk.html

Wednesday, March 18, 2009

Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II

http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html

http://chronic-wasting-disease.blogspot.com/2009/02/exotic-meats-usa-announces-urgent.html

NOT only muscle, but now fat of CWD infected deer holds infectivity of the TSE (prion) agent. ...TSS

just follow the different topics and urls to the science and transmission studies. the transmission studies do not lie. only the politicians do. ...

and you don't even want to go to the mad cow issue and or the scrapie issue, and why should you $$$ your a sports writer, and this is much bigger than any of us will ever be, it was said long ago BSE would never be found in the USA. and due to the incubation period, it probably will not. but the BSE issue is just one phenotype. h and l and c BSE have all been found in North America.......... it's a damn political foot ball game, and we loose, and the animals loose $$$

Monday, July 13, 2009

Deer Carcass Decomposition and Potential Scavenger Exposure to Chronic Wasting Disease

http://chronic-wasting-disease.blogspot.com/2009/07/deer-carcass-decomposition-and.html

CWD, GAME FARMS, BAITING, AND POLITICS

http://chronic-wasting-disease.blogspot.com/2009/01/cwd-game-farms-baiting-and-politics.html

Monday, July 06, 2009

Prion infectivity in fat of deer with Chronic Wasting Disease

http://chronic-wasting-disease.blogspot.com/2009/07/prion-infectivity-in-fat-of-deer-with.html

Friday, February 20, 2009

Both Sides of the Fence: A Strategic Review of Chronic Wasting Disease

http://chronic-wasting-disease.blogspot.com/2009/02/both-sides-of-fence-strategic-review-of.html

Saturday, September 06, 2008

Chronic wasting disease in a Wisconsin white-tailed deer farm 79% INFECTION RATE

Contents: September 1 2008, Volume 20, Issue 5

snip...see full text ;

http://chronic-wasting-disease.blogspot.com/2008/11/commentary-crimes-hurt-essence-of.html

Tuesday, January 27, 2009

Chronic Wasting Disease found in a farmed elk from Olmsted County ST. PAUL, Minn. FOR IMMEDIATE RELEASE: Monday, January 26, 2009

http://chronic-wasting-disease.blogspot.com/2009/01/chronic-wasting-disease-found-in-farmed.html

Saturday, January 24, 2009

Research Project: Detection of TSE Agents in Livestock, Wildlife, Agricultural Products, and the Environment Location: 2008 Annual Report

http://bse-atypical.blogspot.com/2009/01/research-project-detection-of-tse.html

2008 CWD Laboratory Testing for Wild White-tailed Deer

http://www.michigan.gov/emergingdiseases/0,1607,7-186-25806-202922--,00.html

Wednesday, January 07, 2009

CWD to tighten taxidermy rules Hunters need to understand regulations

http://chronic-wasting-disease.blogspot.com/2009/01/cwd-to-tighten-taxidermy-rules-hunters.html

Thursday, December 25, 2008 Lions and Prions and Deer Demise

http://chronic-wasting-disease.blogspot.com/2008/12/lions-and-prions-and-deer-demise.html

http://chronic-wasting-disease.blogspot.com/

Monday, August 24, 2009

Third International CWD Symposium July 22-24, 2009 - Park City, Utah ABSTRACTS

http://chronic-wasting-disease.blogspot.com/2009/08/third-international-cwd-symposium-july.html

Tuesday, July 21, 2009

Transmissible mink encephalopathy - review of the etiology

http://transmissible-mink-encephalopathy.blogspot.com/

Saturday, December 01, 2007

Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model

http://transmissible-mink-encephalopathy.blogspot.com/2007/12/phenotypic-similarity-of-transmissible.html

http://transmissible-mink-encephalopathy.blogspot.com/

PORCINE SPONGIFORM ENCEPHALOPATHY PSE

http://madporcinedisease.blogspot.com/

Thursday, October 15, 2009

Transmissibility studies of vacuolar changes in the rostral colliculus of pigs

http://madporcinedisease.blogspot.com/2009/10/transmissibility-studies-of-vacuolar.html

JOURNAL OF NEUROLOGY

MARCH 26, 2003

RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States

Email Terry S. Singeltary:

flounder@wt.net

I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to comment on the CDC's attempts to monitor the occurrence of emerging forms of CJD. Asante, Collinge et al [1] have reported that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest sporadic CJD. However, CJD and all human TSEs are not reportable nationally. CJD and all human TSEs must be made reportable in every state and internationally. I hope that the CDC does not continue to expect us to still believe that the 85%+ of all CJD cases which are sporadic are all spontaneous, without route/source. We have many TSEs in the USA in both animal and man. CWD in deer/elk is spreading rapidly and CWD does transmit to mink, ferret, cattle, and squirrel monkey by intracerebral inoculation. With the known incubation periods in other TSEs, oral transmission studies of CWD may take much longer. Every victim/family of CJD/TSEs should be asked about route and source of this agent. To prolong this will only spread the agent and needlessly expose others. In light of the findings of Asante and Collinge et al, there should be drastic measures to safeguard the medical and surgical arena from sporadic CJDs and all human TSEs. I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?

http://www.neurology.org/cgi/eletters/60/2/176#535

Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009

August 10, 2009

Greetings,

I would like to submit a review of past CJD surveillance in the USA, and the urgent need to make all human TSE in the USA a reportable disease, in every state, of every age group, and to make this mandatory immediately without further delay. The ramifications of not doing so will only allow this agent to spread further in the medical, dental, surgical arena's. North America seems to have the most species with documented Transmissible Spongiform Encephalopathy's, most all of which have been rendered and fed back to food producing animals and to humans for years. If you look at the statistics, sporadic CJD seems to be rising in the USA, and has been, with atypical cases of the sCJD. I find deeply disturbing in the year of 2009, that Human Transmissible Spongiform Encephalopathy of any strain and or phenotype, of all age groups, and I stress all age groups, because human TSE's do not know age, and they do not know borders. someone 56 years old, that has a human TSE, that has surgery, can pass this TSE agent on i.e. friendly fire, and or passing it forward, and there have been documented nvCJD in a 74 year old. Remembering also that only sporadic CJD has been documented to transmit via iatrogenic routes, until recently with the 4 cases of blood related transmission, of which the origin is thought to be nvCJD donors. However most Iatrogenic CJD cases are nothing more than sporadic CJD, until the source is proven, then it becomes Iatrogenic. An oxymoron of sorts, because all sporadic CJD is, are multiple forms, or strains, or phenotypes of Creutzfeldt Jakob Disease, that the route and source and species have not been confirmed and or documented. When will the myth of the UKBSEnvCJD only theory be put to bed for good. This theory in my opinion, and the following there from, as the GOLD STANDARD, has done nothing more than help spread this agent around the globe. Politics and money have caused the terrible consequences to date, and the fact that TSEs are a slow incubating death, but a death that is 100% certain for those that are exposed and live long enough to go clinical. once clinical, there is no recourse, to date. But, while sub-clinical, how many can one exposed human infect? Can humans exposed to CWD and scrapie strains pass it forward as some form of sporadic CJD in the surgical and medical arenas? why must we wait decades and decades to prove this point, only to expose millions needlessly, only for the sake of the industries involved? would it not have been prudent from the beginning to just include all TSE's, and rule them out from there with transmission studies and change policies there from, as opposed to doing just the opposite? The science of TSE's have been nothing more than a political circus since the beginning, and for anyone to still believe in this one strain, one group of bovines, in one geographical location, with only one age group of human TSE i.e. nvCJD myth, for anyone to believe this today only enhances to spreading of these human and animal TSE's. This is exactly why we have been in this quagmire.

The ones that believe that there is a spontaneous CJD in 85%+ of all cases of human TSE, and the ones that do not believe that cattle can have this same phenomenon, are two of the same, the industry, and so goes the political science aspect of this tobacco and or asbestos scenario i.e. follow the money. I could go into all angles of this man made nightmare, the real facts and science, for instance, the continuing rendering technology and slow cooking with low temps that brewed this stew up, and the fact that THE USA HAD THIS TECHNOLOGY FIRST AND SHIPPED IT TO THE U.K. SOME 5 YEARS BEFORE THE U.S. STARTED USING THE SAME TECHNOLOGY, to save on fuel cost. This is what supposedly amplified the TSE agent via sheep scrapie, and spread via feed in the U.K. bovine, and other countries exporting the tainted product. BUT most everyone ignores this fact, and the fact that the U.S. has been recycling more TSE, from more species with TSEs, than any other country documented, but yet, it's all spontaneous, and the rise in sporadic CJD in the U.S. is a happenstance of bad luck ??? I respectfully disagree. To top that all off, the infamous BSE-FIREWALL that the USDA always brags about was nothing more than ink on paper, and I can prove this. YOU can ignore it, but this is FACT (see source, as late as 2007, in one recall alone, some 10,000,000 MILLION POUNDS OF BANNED MAD COW FEED WENT OUT INTO COMMERCE TO BE FED OUT, and most was never recovered. This was banned blood laced, meat and bone meal. 2006 was a banner year for banned mad cow protein going into commerce in the U.S. (see source of FDA feed ban warning letter below). I stress that the August 4, 1997 USA mad cow feed ban and this infamous BSE firewall, was nothing more than ink on paper, it was never enforceable.

I propose that the current diagnostic criteria for human TSEs only enhances and helps the spreading of human TSE from the continued belief of the UKBSEnvCJD only theory in 2009. With all the science to date refuting it, to continue to validate this old myth, will only spread this TSE agent through a multitude of potential routes and sources i.e. consumption, medical i.e., surgical, blood, dental, endoscopy, optical, nutritional supplements, cosmetics etc. I propose as with Aguzzi, Asante, Collinge, Caughey, Deslys, Dormont, Gibbs, Gajdusek, Ironside, Manuelidis, Marsh, et al and many more, that the world of TSE Transmissible Spongiform Encephalopathy is far from an exact science, but there is enough proven science to date that this myth should be put to rest once and for all, and that we move forward with a new classification for human and animal TSE that would properly identify the infected species, the source species, and then the route. This would further have to be broken down to strain of species and then the route of transmission would further have to be broken down. Accumulation and Transmission are key to the threshold from sub- clinical to clinical disease, and key to all this, is to stop the amplification and transmission of this agent, the spreading of, no matter what strain. In my opinion, to continue with this myth that the U.K. strain of BSE one strain TSE in cows, and the nv/v CJD one strain TSE humans, and the one geographical location source i.e. U.K., and that all the rest of human TSE are just one single strain i.e. sporadic CJD, a happenstance of bad luck that just happens due to a twisted protein that just twisted the wrong way, IN 85%+ OF ALL HUMAN TSEs, when to date there are 6 different phenotypes of sCJD, and growing per Gambetti et al, and that no other animal TSE transmits to humans ??? With all due respect to all Scientist that believe this, I beg to differ. To continue with this masquerade will only continue to spread, expose, and kill, who knows how many more in the years and decades to come. ONE was enough for me, My Mom, hvCJD i.e. Heidenhain Variant CJD, DOD 12/14/97 confirmed, which is nothing more than another mans name added to CJD, like CJD itself, Jakob and Creutzfeldt, or Gerstmann-Straussler-Scheinker syndrome, just another CJD or human TSE, named after another human. WE are only kidding ourselves with the current diagnostic criteria for human and animal TSE, especially differentiating between the nvCJD vs the sporadic CJD strains and then the GSS strains and also the FFI fatal familial insomnia strains or the ones that mimics one or the other of those TSE? Tissue infectivity and strain typing of the many variants of the human and animal TSEs are paramount in all variants of all TSE. There must be a proper classification that will differentiate between all these human TSE in order to do this. With the CDI and other more sensitive testing coming about, I only hope that my proposal will some day be taken seriously. ...

please see history, and the ever evolving TSE science to date ;

Saturday, June 13, 2009

Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009

http://cjdusa.blogspot.com/2009/06/monitoring-occurrence-of-emerging-forms.html

Thursday, November 05, 2009

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

http://creutzfeldt-jakob-disease.blogspot.com/2009/11/incidence-and-spectrum-of-sporadic.html

Tuesday, August 11, 2009

Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants

Brian S. Appleby, MD; Kristin K. Appleby, MD; Barbara J. Crain, MD, PhD; Chiadi U. Onyike, MD, MHS; Mitchell T. Wallin, MD, MPH; Peter V. Rabins, MD, MPH

Background: The classic Creutzfeldt-Jakob disease (CJD), Heidenhain, and Oppenheimer-Brownell variants are sporadic CJD (sCJD) phenotypes frequently described in the literature, but many cases present with neuropsychiatric symptoms, suggesting that there may be additional sCJD phenotypes.

Objective: To characterize clinical, diagnostic, and molecular features of 5 sCJD variants.

Design: Retrospective analysis.

Setting: The Johns Hopkins and Veterans Administration health care systems.

Participants: Eighty-eight patients with definite or probable sCJD.

Main Outcome Measures: Differences in age at onset, illness progression, diagnostic test results, and molecular subtype.

Results: The age at onset differed among sCJD variants (P=.03); the affective variant had the youngest mean age at onset (59.7 years). Survival time (P.001) and the time to clinical presentation (P=.003) differed among groups. Patients with the classic CJD phenotype had the shortest median survival time from symptom onset (66 days) and those who met criteria for the affective sCJD variant had the longest (421 days) and presented to clinicians significantly later (median time from onset to presentation, 92 days; P=.004). Cerebrospinal fluid analyses were positive for 14-3-3 protein in all of the affective variants, regardless of illness duration. Periodic sharp-wave complexes were not detected on any of the electroencephalography tracings in the Oppenheimer-Brownell group; basal ganglia hyperintensity was not detected on brain magnetic resonance imaging in this group either. All of the Heidenhain variants were of the methionine/ methionine type 1 molecular subtype.

Conclusions: The classic CJD phenotype and the Heidenhain, Oppenheimer-Brownell, cognitive, and affective sCJD variants differ by age at disease onset, survival time, and diagnostic test results. Characteristics of these 5 phenotypes are provided to facilitate further clinicopathologic investigation that may lead to more reliable and timely diagnoses of sCJD.

Arch Neurol. 2009;66(2):208-215

snip...

COMMENT

snip...see full text ;

http://creutzfeldt-jakob-disease.blogspot.com/2009/08/characteristics-of-established-and.html

Thursday, November 05, 2009

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

http://creutzfeldt-jakob-disease.blogspot.com/2009/11/incidence-and-spectrum-of-sporadic.html

BSE (Mad Cow) Update: Do Reports of sCJD Clusters Matter?

snip... see full text ;

http://cjdtexas.blogspot.com/

Friday, October 23, 2009

Creutzfeldt-Jakob Disease Surveillance Texas Data for Reporting Years 2000-2008

http://cjdtexas.blogspot.com/2009/10/creutzfeldt-jakob-disease-surveillance.html

Sunday, August 10, 2008

A New Prionopathy OR more of the same old BSe and sporadic CJD

http://creutzfeldt-jakob-disease.blogspot.com/2008/08/new-prionopathy-or-more-of-same-old-bse.html

Research Project: Detection of Transmissible Spongiform Encephalopathy Agents in Livestock, Wildlife, Agricultural Products, and the Environment Location: Foodborne Contaminants Research

Project Number: 5325-32000-008-00 Project Type: Appropriated

Start Date: Apr 07, 2008 End Date: Apr 30, 2012

Objective: We will develop highly sensitive diagnostic tests to detect transmissible spongiform encephalopathy (TSE) in livestock and wildlife animal species prior to the onset of clinical disease. We will also develop tests to confirm the presence or absence of TSE disease agents in ingredients of animal origin and decontaminated environments.

Approach: The threat of BSE continues to affect export economics for US meat. Meanwhile scrapie continues to influence sheep profits and herd biosecurity, and CWD is spreading throughout North America. Thus U.S. animal industry stakeholders have identified detection of the TSE infectious agent (prions) as a priority biosecurity research issue essential for prevention of TSE diseases. We will build on our previous successes using mass spectrometry (MS) for high-sensitivity and specificity in detection of PrPsc as a marker for TSE infectivity in blood using a hamster scrapie model. We will also develop a novel PrP-null mouse strain and related myeloma cell culture system for production of monoclonal antibodies (MAb), which may be specific for PrPsc. We will then choose MS or MAb and validate our novel diagnostic for preclinical diagnosis of scrapie in sheep blood. Whereas MS and MAb methods rely on dissolved samples, contamination of agricultural products and environmental surfaces is associated with solid samples. So we will produce a cell culture based assay for TSE infectivity that is surface-adsorbed. After using the relatively convenient hamster model for early development, we will validate this technology for detection of scrapie in sheep brain on meat-and-bone meal and stainless steel. All work with infectious material will take place within our APHIS-approved BL2 biocontainment facilities labs at the Western Regional Research Center (WRRC), while mass spectrometry will be performed on non-infectious material under BL1 containment. Replacing 5325-32000-007-00D (3/19/2008).

http://www.ars.usda.gov/research/projects/projects.htm?accn_no=413072

2008 Annual Report

http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=413072&showpars=true&fy=2008

WE MUST TEST ALL LIVESTOCK PRODUCING ANIMALS FOR HUMAN AND ANIMAL FOOD FOR TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY.

WE MUST MAKE CJD AND ALL HUMAN TSE A REPORTABLE DISEASE OF ALL AGE GROUPS, IN EVERY STATE, AND INTERNATIONALLY.

and foremost, we must do these things properly. ...

Terry S. Singeltary Sr.

P.O. Box 42

Bacliff, Texas USA 77518

Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan

2009-11-10T15:29:00.000-08:00

AHRI.,No.40 : 51-63 (2004)

Surveillance of Transmissible Spongiform Encephalopathy and Rabies in 2004

Shu-Hwae LEE, Kwok-Rong TSAI, Kuo-Hui CHANG, Jen-Chieh CHANG, Che-tun HUNG, Lu-Jen TING , Wastson H. T. SUNG

Animal Health Research Institute, Council of Agriculture, Executive Yuan

We have applied histopathology, immunohistochemistry, Western immunoblot assay, and enzyme-linked immunosorbent assay techniques in the continuous surveillance program of bovine spongiform encephalopathy (BSE). Among the 859 cattle brains, 826 brains were collected randomly from the abattoirs, 3 from the M. tuberculosis-contaminated farms, 6 from the sick cows imported from Canada, 1 from the bovine ephemeral fever virus infected cattle and 23 from the culling old cattle in Taiwan in 2004. Cattle developed central nervous signs or showed other symptoms were also included. All of the brains were negative. Additionally, histopathological observation and direct immunofluorescent antibody were also applied to examine 1 rabies-suspected case with nervous symptom and 79 brain tissues of stray dogs in 2004. Rabies viral antigens and typical lesion were not detected in all tissues indicating free status of rabies in Taiwan. On the other hand, 3,204 sera samples including 1,380 samples from domestic dogs and 1,821 samples from stray dogs were examined by the enzyme-linked immunosorbent assay. Results showed that the sera-positive rate of domestic and stray dogs were 58.6% (809/1,380) and 35.9% (654/1,821), respectively.

Key words: TSE, rabies, surveillance

http://agbio.coa.gov.tw/image_doc/51-63.pdf

REPORT NO. AHRI report No38

Topic Surveillance On the Bovine Spongiform Encephalopathy and rabies in Taiwan in 2002

Department Animal Health Research Institute, Council of Agriculture, Executive Yuan

Author LEE Shu-Hwae, Kou-Hei CHANG, Kwok-Rong TSAI, Lu-Jen TING, Jong-Rong SHIAU, Shih-Yuh LIN

We have established a fast and accurate screening technique based On immunopathology to detect bovine spongiform encephalopathy (BSE) from bovine and ovine brain tissues standard operation procedures for the screening of BSE and rabies were established too. By following these procedures, the risk of BSE from imported food and the spread and damage of BSE and rabies would be greatly reduced. A total of 647 cattle brains aged older than 30 months (4.2-year-old in average) were screened in 2002. Totally, 1,385 brain sections colleced from the abanoirs and M. tuberculosis contaminated farms scattered through 11 counties, including Taoyang, Taichung, Chunghwa, Yunling, Nantao, Tainan, Pingtung, Ilan, Taitung, Panfu, and Kingmen, were examined. None of those samples showed spongiform change in pathology. Besides, enzyme-linked immunosorbent assay and Westem immunoblot assay were used to examine 647 cattle brains and 90 cattle brains collected since 1999 to 2002, also showing negative results in prion protein. These results would be submitted to the World Organisation for Animal Health to claim that Taiwan is a BSE free area. Fifty-Six canaine brains were also examined in histopathological sections and stained with direct immunofluorescent antibodies, showing negative results. An enzyme-linked immunosorbent assay was applied to detect the specific antibodies to rabies in 4,317 dog serum. samples. Among those serum samples, 1,946 samples were from domestic dogs and 2,371 were from stray dogs. Result revealed that 41.0% of domestic dogs and 21.4 % of stray dogs were positive in ELISA.

Keyword bovine spongiform encephalopathy; rabies; Surveillance; Taiwan

http://eng.nvri.gov.tw/News/PublicationDetail.aspx?ID=516

REPORT NO. AHRI report No36

TOPIC Surveillance on Bovine Spongiform Encephalopathy in Taiwan in 1998-2000

Department Animal Health Research Institute, Council of Agriculture, Executive Yuan

Author Lee, Shu-Hwae , Kou-Hei Chang, Min-Chao Weng, Jei-Fu Su and Shih-Yuh Lin

In order to fulfill the Office International des Epizooties (OIE) requirements for the statement of free area of bovine spongiforrn encephalopathy (BSE), 85 cattle brains were collected from the abattoirs, rendering plants and the cattle herds infected by M. tuberculosis located in 8 prefectures of Taiwan. Cattle developed CNS signs or showed other symptoms were also included. A total of 850 brain histologic tissue sections (10 sections/brain) were examined. None of the 850 brain tissue sections showed evidence related to spongiform change. Then, thirty out of the 85 brain tissue sections were examined further by the Western blot diagnostic kit. No evidence of prion was found. These results could therefore provide for OIE to recognize Taiwan as a free Country of BSE.

Keyword Bovine spongiform encephalopathy, M. tuberculosis, brain tissue sections

http://eng.nvri.gov.tw/News/PublicationDetail.aspx?ID=500

AHRI report No.37

Topic Establishment of the Laboratory Diagnostic Techniques and Monitormg of Bovine Spongiform Encephalopathy in Taiwan

Department Animal Health Research lnstitute, Council of Agriculture

Authur Kuo-Hui Chang*, Shu-Hwae Lee, Min-Chao Weng, Jei-Fu Su, Shih- Yuh, Lin

Summary To prevent bovine spongiform encephalopathy (BSE) from entering our country, we have established the BSE laboratory diagnostic techniques, including the laboratory biosafety, histopathology, immunohistochemistry, Western immunoblot assay, and enzyme-linked immunosorbent assay. We have also applied those techniques to the continuous surveillance program of BSE. A total of 127 cattle brains were collected from the abattoirs, rendering plants, and M. tuberculosis-conaminated farms located in 10 counties of Taiwan during 1998 to 2001. Cattle developed central nerous signs or showed other symptoms were also included. All the brains were examined and present negative results.

Keywords bovine spongiform encephalopathy, mad cow disease, prion, laboratory diagnostic techniques

http://eng.nvri.gov.tw/News/PublicationDetail.aspx?ID=457

Pathological Diangosis and Services for Animal Diseases in Taiwan in 2002

http://eng.nvri.gov.tw/News/PublicationDetail.aspx?ID=517#

Republic of Korea Livestock and Products Sem-Annual 2008 This article provides the cattle industry data from the USDA FAS Livestock and Products Semi-Annual 2008 report for the Republic of Korea. A link to the full report is also provided. The full report includes all the tabular data, which we have omitted from this article.

2009

Annual and Semi

2008

Annual

Semi-Annual

2007

Annual

Semi-Annual

Report Highlights: Imports of beef are projected to remain stable in 2008 at 310,000 metric tons. Increases in domestic inventory will alleviate some of the unmet demand for animal protein. Lower international pork prices in the United States and increasinly lower tariffs for Chilean pork will make imported pork and pork products more price competitive this year. Total imports of pork are forecast at 452,000 tons, an increase of 2.5 percent from 2007. The domestic livestock industry is facing higher feed prices this year and will likely increase slaughter rates from those initially forecasted.

Situation and Outlook The political landscape in Korea is changing. On February 25, a new conservative president, Lee Myung-bak, was sworn into office after 10 years of liberal rule. During his campaign the new president made a “747” jumbo election pledge to revive Korea's economy by achieving seven percent annual growth, per-capita national income of $40,000 and making Korea the world’s seventh largest economy in 10 years. Currently, exports are still strong, but the world economy is slowing and Korea may begin to feel the effects in the second half of this year. Imports are forecast to rise considerably this year due to high oil, grain and raw material prices. As a result, the economic forecast for 2008 is expected to be just under five percent.

With a new president, comes a new government. The new Minister for Food, Agriculture, Forestry & Fisheries (MIFAFF),, Jung Un-chun (also spelled Chung Woon-chun) has stated that “the country’s agriculture policy should no longer be passive and protective, but instead should be proactive and aggressive.” As a result, Jung’s nomination drew mixed reviews from rank-and-file farmers. The new Minister is likely to deal with the beef issue, while at the same time explore ways to provide additional debt relief to farmers in order to gain their support for the Korea-U.S. free trade agreement.

Imports of beef are projected to rema in stable in 2008; although the forecast was dropped slightly on account of higher slaughter rates. This increase in domestic production will result in a 5 percent increase in consumption compared to last year. The unmet demand for beef in Korea is quite high given that per capita consumption in 2007 (7.5 kg) is still below the 2003 level (8.1 kg) and well below the level in the United States (about 30.5 kg).

Increased swine slaughter in 2008 resulting in higher expected domestic production is the main reason that the forecast for pork imports was lowered. Imports of pork will increase year on year due to lower international prices. Increased U.S. swine production and the steady decline in tariff rates for Chilean pork will make imported pork more price competitive this year. The demand for pork, even though it is at record levels (19.7 kg), probably still has room for growth.

Domestic prices for live cattle and swine depend on slaughter rates. Higher prices for imported corn and soybeans, ingredients used locally in compound livestock feeds, will increase costs for the farmer. Judging by past history, farmers are likely to sell off their cattle at higher rates if their costs increase. Higher slaughter rates will result in lower live animal prices and lower wholesale prices for beef and pork; however, this does not necessarily translate into lower retail prices for the consumer. Retail prices tend to remain stable, changing only when external pressures force retailers to lower their prices. Absent U.S beef, the price of imported beef will increase as the higher costs of production in exporting countries are passed on to buyers.

Beef and Beef Products Production Inventory levels are expected to remain high regardless of whether or not U.S. beef returns to the market in 2008. Korea's total cow beginning stock levels in 2008 are five percent higher than those compared to this same time last year. High cow numbers will permit farmers to increase their herd sizes in 2008. In addition, 595,000 head of Hanwoo were artificially inseminated in the second half of 2007, an increase of 19.7 percent from the same period in 2006. With such high insemination rates and beginning stock levels, the total inventory is not expected to come down until at least 2009.

The conclusion of the KORUS FTA negotiations in early April 2007 and the brief resumption of U.S. beef imports that began in April 2007 after the bone chip issue was partially resolved had a huge impact on domestic beef prices. Live cow prices dropped over four percent from an average of 4,960,000 won (about $5,221, at an exchange rate of US$1=950 won) per head in April 2007 to 4,786,000 won (about $5,038) in May 2007, after the arrival of the first beef shipment on April 23, 2007. This decline continued until U.S. beef was shut off again on October 5, 2007. Since then, however, prices have begun to move upward again.

The price drop provoked farmers to sell off their stock and send cattle to slaughter. During the four month period (May-August) after U.S. beef imports resumed and prior to the Korean Thanksgiving Holidays (October), beef cattle slaughter jumped 6.7 percent in 2007 compared to the same period in 2006. The cow-steer slaughter ratio jumped to 45.9:54.1 during this four-month period, compared to 44.7:55.3 during the same period in 2006 and the 2006 annual average ratio of 43.3:56.7. Despite the short-term panic, Korea still maintains a very high level of Hanwoo inventory; however increased feed grain prices will have a direct effect on production costs and in the long run will cause less competitive farmers to stop producing cattle.

Korea was recognized by the World Organization for Animal Health (OIE) as being free from Foot & Mouth Disease (FMD) in 2002. Korea has requested that other countries, including the United States recognize its OIE status.

Korea’s beef self-sufficiency ratio has increased from 36.1 percent in 2003 to 46.9 percent in 2007; however, this is not because of an increase in production but rather a drop in consumption. The high price of beef in Korea has resulted in decreased demand for all beef, domestic and imported. When U.S. beef enters the market, as seen in 2007, the effect is more competition, more choice and lower prices for consumers resulting in increased demand that may actually be beneficial to the domestic industry. Increased availability of beef does not replace current suppliers, it expands the whole market. There is a market for Hanwoo beef that will remain even if U.S. beef is present; but not all consumers can eat Hanwoo beef given the cost. After the market was liberalized in 2000, Hanwoo production did not go away and even in 2007, with some U.S. beef available, Hanwoo sales actually increased and production grew.

Source: U.S. Meat Export Federation/Korea and the National Agric ultural Cooperative Federation Consumption Beef consumption is projected to continue to increase in 2008 as it did in 2007 due to higher domestic production. Prices dropped slightly in 2007 due to the availability of U.S. beef from May to October and this contributed to an increase in consumption of beef from all origins.

Korean consumers are still concerned about the safety of U.S. beef. The chart of U.S. beef retail sales shows that with each finding of backbone, sales dropped. According to a recent survey, 85.5 percent of consumers stated that they worry about the safety of U.S. beef.

According to the Ministry of Agriculture and Forestry (MAF), Korean consumers purchased beef 1.59 times per month in 2007 (up from 1.53 times per month in 2006) and spent an average of 36,100 Korean won per purchase (up from 27,980 Korean won in 2006). Consumers seem to be willing to spend more to purchase beef than they are to purchase pork or poultry. In addition, MAF is providing support to livestock producers to develop brands that provide consumers with more information about the meat they are buying. The awareness of brands is growing. In 2007, 34.5 percent of consumers said they were aware of beef brands, a marginal increase from 34.4 percent in 2006. In a recent survey, over half stated that they were willing to pay an additional 5-10 percent more for a branded meat product.

Source: U.S. Meat Export Federation/Korea Very little beef is consumed in the form of processed meat in Korea and virtually all beef is purchased for direct cooking, either in the form of Korean barbeque, soup, and other Korean dishes. Only 600 tons of imported beef rounds from Australian and New Zealand are processed into beef jerky by a domestic company.

The most popular cuts of beef are bone-in short ribs, loins and chuck rolls. Short ribs are consumed mainly for Korean barbeque or kalbi. Loins are also used for Korean barbeque while chuck roll is used for making bulgoki, shaboo shaboo and steak. As Koreans like to barbeque their beef, well marbled beef receives higher prices over lean meat. Also, as consumers are accustomed to grainfed beef, they prefer such beef over grass-fed. Thus, Australia which used to supply grass-fed beef is now switching to grain-fed beef. Grass-fed beef is often marinated in order to cover the grass flavor that Koreans do not like. There is also a preference for fresh chilled beef rather than frozen beef. During the period when U.S. beef was banned, not only did the total amount of short rib imports drop, but Australian clod replaced chuck rolls for bulgoki.

Source: U.S. Meat Export Federation/Korea Trade Total imports of beef and beef products in 2008 are forecast at 310,000 metric tons (carcass weight equivalent). Since a commercially viable protocol for U.S. beef currently does not exist, this report makes no projection regarding imports of U.S. beef. Therefore, imports of beef from current sources are projected to remain stable from last year. The current 2008 forecast is down from the previous 2008 forecast when it was expected that a small amount of U.S. boneless beef would be imported.

The total beef import market has never really returned to the level prior to the ban on U.S. beef at the end of December 2003. Despite aggressive marketing of grain fed beef by Australia, total beef imports are still far below the 2003 level.

U.S. Beef Imports Before the BSE ban was imposed at the end of 2003, beef was the top U.S. agricultural export to Korea and Korea was the third largest beef market for the United States. A beef protocol for deboned skeletal muscle meat was established in January 2006 and after an audit of all 36 plants eligible to export by the Korean quarantine authorities, the market was theoretically opened in September 2006. After three successive shipments, each one rejected due to bone fragment findings; Korea published slightly less onerous inspection procedures in March 2007. The new procedures indicated that all shipments would be subject to 100% inspections with x-ray machines, but that the rejections will only be limited to the box and not the entire shipment. These new inspection procedures enticed U.S. exporters to begin shipping boneless U.S. beef. On August 1, a vertebral column finding, a bone that Korea considered specified risk material (SRM) resulted in a quarantine inspection suspension for one month. This suspension was lifted on August 24; however, it was reinstated on October 5 when another vertebral column was found. This latest suspension is anticipated to remain until a bone-in protocol is negotiated. There is about 5,000 tons of beef that is in the bonded area; this beef has arrived, but has not been inspected.

Beef Tariffs and the Korea-U.S. Free Trade Agreement The Korea-U.S. free trade agreement was concluded on April 1, 2007; however, neither the Korean National Assembly nor the U.S. Congress has ratified the agreement. Although the continued quarantine inspection suspension limits the ability of the United States to ratify this agreement, it does have some significant benefits for U.S. red meat exporters.

Korean tariffs on imports of beef muscle meats will decline to zero from the current 40 percent tariff in 15 equal annual reductions. A trade level similar to Korea's average imports from 2001 to 2003 of 182,800 metric tons of U.S. muscle meats valued at $569 million; implementation of the Korea-U.S. free trade agreement translates into a tariff savings of $15 million in year one of the agreement. Once tariffs are completely phased out, the annual tariff savings will be an estimated $1,300 per ton.

The agreement does includes a quantity safeguard of 270,000 tons for beef muscle meats, growing at a compound 2-percent annual rate to a final safeguard level of 354,000 tons in 15 years. In year 16 and beyond, safeguards will no longer apply. In 2003, the United States exported a record 224,000 metric tons of beef to Korea. This amount is still far below the trigger level in year one.

Korean tariffs on beef offal also decline in 15 equal annual reductions from their current 18- or 17-percent levels.

http://www.thecattlesite.com/articles/1371/republic-of-korea-livestock-and-products-semannual-2008

Release No. 0545.09 Contact: Carol Guthrie (USTR) 202-395-3230 Chris Mather (USDA) 202-720-4631

Joint Statement from USTR and USDA Spokeswomen Regarding Expanded Market Access for U.S. beef in Taiwan

Washington, Nov. 2, 2009 - The Office of the United States Trade Representative and the U.S. Department of Agriculture today released a brief statement regarding Taiwan's announcement on the import of American beef. The following statement is from Carol Guthrie, Assistant United States Trade Representative for Public Affairs, and Chris Mather, USDA Director of Communications:

"After over two years of extensive negotiations and scientific and technical exchanges, the United States has been looking forward to an announcement from Taiwan authorities that Taiwan would fully open its market to American beef and beef products on the basis of the bilateral protocol we have negotiated. The Protocol that Taiwan promulgated today is science-based and follows the guidelines of World Organization of Animal Health (OIE) as well as the findings of Taiwan's own risk assessment on the safety of U.S. beef. We understand today that Taiwan also announced a number of other additional domestic measures regarding beef and beef products. We are currently reviewing these measures to ensure they allow Taiwan consumers the opportunity to enjoy the same safe American beef and beef products that American families eat. We look forward to working with our partners in Taiwan to ensure that Taiwan's domestic requirements are consistent with the Protocol, the science, the OIE guidelines, and Taiwan's international obligations."

#

USDA is an equal opportunity provider, employer and lender. To file a complaint of discrimination, write: USDA, Director, Office of Civil Rights, 1400 Independence Avenue, SW, Washington, DC 20250-9410 or call (800) 795-3272(voice), or (202) 720-6382 (TDD).

# USDA News oc.news@usda.gov 202 720-4623

*****************************

Greetings,

NOW, let's look at some _facts_. they seem to get over looked some times, and from time to time, we should look at _all_ the facts. ...TSS

I. EXECUTIVE SUMMARY On December 12, 2005, after nearly two years of banning the export of beef from the United States, Japan resumed beef trade with the United States. On January 20, 2006, Japan government officials discovered 3 boxes of veal with vertebral column shipped from the United States. Vertebral column is not allowed under the specific trade agreement with Japan. The United States acknowledges this was unacceptable because it did not meet the terms of our agreement with Japan, but emphasized that the product did not present a health risk to the public.

http://www.fsis.usda.gov/pdf/japan_export_investigation_report.pdf

http://www.fsc.go.jp/iinkai/i-dai132/dai132kai-siryou4_3.pdf

Box 3.1 Key events in recent U.S.-Korea Beef Trade • Prior to Korea's ban on imports of U.S. beef following the discovery BSE in a Canadian-born cow in the state of Washington in late 2003, Korea imported an average of 5,670 tons of U.S. beef—primarily “short ribs”— per month. Product primarily consisted of “short ribs.” • In September 2006, Korea allowed U.S. shipments of boneless beef to resume, albeit with a “zero” tolerance policy for bone chips or other material considered “at risk.” In addition, Korea will not accept beef from animals over 30 months of age, which is a more stringent approach than international standards of the World Organization for Animal Health (also known as the OIE). • In late May 2007, OIE classified the United States as a “Controlled Risk” region for BSE. Controlled Risk is the second highest safety rating. • Korea rejected the first three shipments of U.S. beef after reopening its market in September 2006 upon finding bone fragments in several boxes. Typically beef is shipped in prepackaged boxes. U.S. beef is mechanically deboned, which invariably results in small bone fragments, although this is considered commercially acceptable in the industry. The entire shipment, instead of the individual boxes, was rejected. • In June 2007, several boxes of ribs were found in a shipment to Korea resulting in a “stoppage” of U.S. shipments. After a USDA investigation it was determined that the shipment was safe and was meant for U.S. domestic sale and mistakenly sent to Korea. Korea is presently accepting U.S. boneless beef and has indicated that it will only return individual boxes instead of entire shipments. • Negotiations are currently ongoing. Sources: World Organization for Animal Health (OIE). Official Animal Health Status, “Bovine Spongiform Encephalopathy”; Industry officials, e-mail and telephone correspondence with Commission staff, Washington, DC, June 2007; Johnston, Tom. “South Korea Reopens to U.S. Beef Imports,” June 8, 2007; and USDA, FAS, “Korea Lifts Suspension of Six U.S. Meat Plants,” June 25, 2007.

http://www.strtrade.com/wti/2007/september/21/itc_korea_fta_report.pdf

2006/12/01 11:45 KST

Seoul again rejects U.S. beef on bone chip discovery

SEOUL, Dec. 1 (Yonhap) -- South Korea said Friday it has rejected a shipment of three tons of U.S. beef because bone chips were found in the meat, the second case in just three weeks.

On Nov. 24, South Korea, the third-largest buyer of U.S. beef in 2003, rejected the first shipment of the meat to arrive here since lifting a three-year ban imposed out of fear of mad cow disease in September this year, saying it found bone fragments, which violated an agreement.

"The bones do not seem to be specified risk material, but it violates the agreement with the United States to ship only boneless beef," the National Veterinary Research & Quarantine Service said in a statement.

Under the agreement, U.S. beef suppliers to South Korea are required to ensure that bones, spinal cord and brains are removed from the meat. Also, the beef must come from cattle no older than 30 months.

Seoul imposed bans on U.S. beef after an animal with mad cow disease was found in the state of Washington in December 2003.

South Korea had been under pressure from the U.S. to resume beef imports amid negotiations for a free trade agreement with the U.S.

The two countries are aiming to conclude the talks by the first quarter of next year so President George W. Bush can approve it before his trade authority expires in July 2007.

A beef trade dispute may be one of the major hurdles in the upcoming talks to be held in Montana next week, watchers said.

Mad cow disease is a brain-wasting livestock illness. Hunans eating contaminated meat from infected animals can contract a fatal form of the disease.

(END)

http://english.yonhapnews.co.kr/Engnews/20061201/640000000020061201114548E1.html

specified risk material (SRM), would carry infectivity. For bovine animals the SRM are the skull including the brain, eyes, trigeminal ganglia, tonsils, thymus, spleen, and the spinal cord of animals over 12 months of age; the vertebral column (including dorsal root ganglia) of animals over 12 months of age, and the intestines (from duodenum to rectum) of animals of any age. The absence of an age limit for intestines resulted from experimental data demonstrating BSE infectivity in the distal ileum of animals very early after challenge with the BSE agent. The current list of SRM for the European Union is detailed in Appendix 3.

http://www.foodstandards.gov.au/_srcfiles/fixed%20BSE%20RA%20version%20Aug02.pdf

Another Bone Fragments Found in US Beef

By Kim Yon-se Staff Reporter The government said it found seven bone fragments in the third batch of beef shipment from the United States.

It is the third time that South Korea has found bone pieces since September when it decided to resume the import of American beef.

``The meat is from cattle slaughtered in Nebraska and processed in Iowa,¡¯¡¯ said Kang Mun-il, director general of the National Veterinary Research & Quarantine Service (NVRQS).

The quarantine service said that the fragments were found in the 10.2 tons of chuck short ribs from U.S. cattle. The NVRQS inspected only 5 percent, or 10 of the 651 boxes that arrived in Korea on Dec. 1.

Bone inclusion in shipments is a violation of import conditions between the two countries. The beef will be sent back to the U.S. or destroyed, the quarantine service said.

South Korea had refused U.S. beef due to its concern over a case of mad cow disease reported in the U.S. in 2003.

The government had said it would return or destroy the two previous shipments on Nov. 24. and Dec. 1 as a bone fragment and three fragments were found in the beef from Kansas and Nebraska, respectively.

``I heard that the U.S. also conducted an X-ray test _ on the third batch _ before shipment,¡¯¡¯ Kang said. ``The possibility that the U.S. failed to detect the bone fragments is high because they were so thin.¡¯¡¯

He rejected some reports that U.S. beef with bone fragments have already been consumed by some U.S. soldiers here and Koreans. He said, ``I think the reports are groundless as the beef should be destroyed or sent back.¡¯¡¯

kys@koreatimes.co.kr

KOREA

12-06-2006 21:20

Note: Values may not sum to totals shown because of rounding. Includes HS 2304. The value of U.S. exports of animal feed preparations46 (mixed feeds) to Korea has increased 51 percent over the 2002 to 2006 period.47 The United States has been a leading supplier to Korea from 2002 to 2006 (table 3.5), and the immediate removal of Korean tariffs (4.2 or 5 percent) as a result of implementation of the FTA would likely improve the U.S. competitiveness against China and other leading exporters. The United States is the leading supplier of pet food48 exports to Korea, with a market share of more than 50 percent (table 3.6); Korea is the eighth-largest U.S. export market for pet foods.49 Korea’s pet food consumption is expected to increase over the next several years as the trend toward pet ownership becomes increasingly popular as disposable incomes continue to rise and multiple pet households become more common.50 The immediate removal of the 5 percent tariff on pet food under the FTA would likely allow the United States to increase its already dominant market share against leading competitors.

Korea, however, has SPS and technical barriers to trade (TBT) measures that have constrained U.S. pet food exports. Interpretation and implementation of the FTA’s TBT chapter and the actions of the standing committee established by the FTA’s SPS chapter would likely be important to fully realize these gains in market access.51 As a result of the U.S. outbreak of bovine spongiform encephalopathy (BSE) in 2003, Korea has banned U.S. exports of pet foods containing beef or other ruminant products. Additionally, Korea requires that U.S. exports of pet food containing animal proteins, including fish meal, need to be certified that they are entirely of U.S. origin. Consequently, animal proteins from other countries, which could be lower-cost, are prohibited in pet foods. In addition, pet food importers are required to provide a full ingredient list with percentages of each ingredient by weight for registration at provincial government offices. The absence of Korean safeguards to prevent disclosure of this proprietary information has disrupted U.S. exports of pet food to Korea.52 U.S. exports of distiller’s dried grains with solubles (DDGS) to Korea were negligible until 2004, but have risen sharply since then (table 3.7). A large proportion of DDGS are 53 Shurson, “Benefits and Limitations of Using DDGS in Swine Diets,” January 25, 2007. 54 ATAC for Grains, Feed, and Oilseeds, Advisory Committee Report, April 25, 2007, 6. 55 Ibid. 56 American Soybean Assoc., “American Soybean Association Applauds Korean Trade Agreement (April 3, 2007).” 57 National Oilseed Processors Assoc., “NOPA Strongly Supports Korea Free Trade Agreement (April 4, 2007).” 3-12 consumed domestically by the U.S. livestock industry, but its domestic use is presently constrained in animal rations because of nutritional limitations such as digestibility, protein quality, and energy values.53 As a result, the exportable surplus of DDGS has increased with the expansion of the U.S. ethanol industry, and the United States is now the leading exporter of DDGS to Korea with a market share of over 60 percent in 2006. The immediate removal of the 5 percent tariff on DDGS as a result of implementation of the FTA would further increase the competitiveness of the United States against China, the other primary supplier. This improved access would be expected to result in DDGS having a greater inclusion in feed rations in future years as Korea’s feed manufactures seek to diversify sources.54

http://www.strtrade.com/wti/2007/september/21/itc_korea_fta_report.pdf

----- Original Message -----
From: "Terry S. Singeltary Sr."
To:
Sent: Wednesday, November 04, 2009 2:32 PM

[BSE-L] re-FOIA REQUEST ON FEED RECALL PRODUCT contaminated with prohibited material Recall # V-258-2009 and Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html

Friday, September 4, 2009

FOIA REQUEST ON FEED RECALL PRODUCT 429,128 lbs. feed for ruminant animals may have been contaminated with prohibited material Recall # V-258-2009

http://madcowfeed.blogspot.com/2009/09/foia-request-on-feed-recall-product.html

Saturday, August 29, 2009

FOIA REQUEST FEED RECALL 2009 Product may have contained prohibited materials Bulk Whole Barley, Recall # V-256-2009

http://madcowfeed.blogspot.com/2009/08/foia-request-feed-recall-2009-product.html

2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006

http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html

GREETINGS HONORABLE PEOPLE OF TAIWAN,

I wish to send you the following data on USA mad cow disease and cjd.

I am not anti-meat. I am anti-stupid, and stupid is as stupid does.

WHO WILL WATCH THE CHILDREN for CJD over the next 5 decades ?

FOR 4 years, the USDA fed dead stock downer cows, the most high risk cattle for mad cow disease and other dangerous pathogens to children all across the USA via the USDA certified dead stock downer cow school lunch program...

SCHOOL LUNCH PROGRAM FROM DOWNER CATTLE UPDATE

http://downercattle.blogspot.com/2009/05/who-will-watch-children.html

http://downercattle.blogspot.com/

BOVINE SPONGIFORM ENCEPHALOPATHY (typical and atypical strains)

Monday, October 19, 2009

Atypical BSE, BSE, and other human and animal TSE in North America Update October 19, 2009

http://bse-atypical.blogspot.com/2009/10/atypical-bse-bse-and-other-human-and.html

Sunday, September 6, 2009

MAD COW USA 1997 SECRET VIDEO SEE VIDEO

http://madcowusda.blogspot.com/2009/09/mad-cow-usa-1997-video.html

U.S.A. HIDING MAD COW DISEASE VICTIMS AS SPORADIC CJD ? SEE VIDEO at bottom

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON PRIONS SPEAKING ABOUT ANN VENEMAN SEE VIDEO

http://maddeer.org/video/embedded/prusinerclip.html

CVM Annual Report Fiscal Year 2008: October 1, 2007-September 30, 2008

PUTTING LIPSTICK ON A PIG AND TAKING HER TO A DANCE...TSS

BSE Feed Rule Enforcement: A Decade of Success OFF TO A FAST START

http://madcowfeed.blogspot.com/2008/06/texas-firm-recalls-cattle-heads-that.html

2009 UPDATE ON ALABAMA AND TEXAS MAD COWS 2005 and 2006

http://bse-atypical.blogspot.com/2006/08/bse-atypical-texas-and-alabama-update.html

Sent: Tuesday, November 03, 2009 5:14 PM
Subject: Re: FOIA REQUEST ON FEED RECALL PRODUCT Bulk Whole Barley, Recall # V-256-2009 DISTRIBUTION TX END OF ENFORCEMENT REPORT FOR AUGUST 26, 2009

http://madcowfeed.blogspot.com/2009/11/re-foia-request-on-feed-recall-product.html

10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN COMMERCE USA 2007

Date: March 21, 2007 at 2:27 pm PST

RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINES -- CLASS II

___________________________________

PRODUCT

Bulk cattle feed made with recalled Darling's 85% Blood Meal, Flash Dried, Recall # V-024-2007

CODE

Cattle feed delivered between 01/12/2007 and 01/26/2007

RECALLING FIRM/MANUFACTURER

Pfeiffer, Arno, Inc, Greenbush, WI. by conversation on February 5, 2007.

Firm initiated recall is ongoing.

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

___________________________________

PRODUCT

Custom dairy premix products: MNM ALL PURPOSE Pellet, HILLSIDE/CDL Prot- Buffer Meal, LEE, M.-CLOSE UP PX Pellet, HIGH DESERT/ GHC LACT Meal, TATARKA, M CUST PROT Meal, SUNRIDGE/CDL PROTEIN Blend, LOURENZO, K PVM DAIRY Meal, DOUBLE B DAIRY/GHC LAC Mineral, WEST PIONT/GHC CLOSEUP Mineral, WEST POINT/GHC LACT Meal, JENKS, J/COMPASS PROTEIN Meal, COPPINI - 8# SPECIAL DAIRY Mix, GULICK, L-LACT Meal (Bulk), TRIPLE J - PROTEIN/LACTATION, ROCK CREEK/GHC MILK Mineral, BETTENCOURT/GHC S.SIDE MK-MN, BETTENCOURT #1/GHC MILK MINR, V&C DAIRY/GHC LACT Meal, VEENSTRA, F/GHC LACT Meal, SMUTNY, A- BYPASS ML W/SMARTA, Recall # V-025-2007

CODE

The firm does not utilize a code - only shipping documentation with commodity and weights identified.

RECALLING FIRM/MANUFACTURER

Rangen, Inc, Buhl, ID, by letters on February 13 and 14, 2007. Firm initiated recall is complete.

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/bbs/topics/enforce/2007/ENF00996.html

NEW URL

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm

Thursday, March 19, 2009

MILLIONS AND MILLIONS OF POUNDS OF MAD COW FEED IN COMMERCE USA WITH ONGOING 12 YEARS OF DENIAL

http://madcowfeed.blogspot.com/2009/03/millions-and-millions-of-pounds-of-mad.html

Sunday, October 18, 2009

Wisconsin Firm Recalls Beef Tongues That Contain Prohibited Materials SRM WASHINGTON, October 17, 2009

http://madcowfeed.blogspot.com/2009/10/wisconsin-firm-recalls-beef-tongues.html

Thursday, October 15, 2009

Nebraska Firm Recalls Beef Tongues That Contain Prohibited Materials SRM WASHINGTON, Oct 15, 2009

http://madcowfeed.blogspot.com/2009/10/nebraska-firm-recalls-beef-tongues-that.html

Tuesday, July 14, 2009

U.S. Emergency Bovine Spongiform Encephalopathy Response Plan Summary and BSE Red Book Date: February 14, 2000 at 8:56 am PST

WHERE did we go wrong $$$

http://madcowtesting.blogspot.com/2009/07/us-emergency-bovine-spongiform.html

Sunday, December 28, 2008

MAD COW DISEASE USA DECEMBER 28, 2008 an 8 year review of a failed and flawed policy

http://bse-atypical.blogspot.com/2008/12/mad-cow-disease-usa-december-28-2008-8.html

Monday, May 11, 2009

Rare BSE mutation raises concerns over risks to public health

http://bse-atypical.blogspot.com/2009/05/rare-bse-mutation-raises-concerns-over.html

SCRAPIE (typical and atypical strains)

Tuesday, November 10, 2009

A retrospective immunohistochemical study reveals atypical scrapie has existed in the United Kingdom since at least 1987

Brief Research Reports

http://nor-98.blogspot.com/2009/11/retrospective-immunohistochemical-study.html

NOR-98 ATYPICAL SCRAPIE 5 cases documented in USA in 5 different states USA 2007

http://nor-98.blogspot.com/2008/04/seac-spongiform-encephalopathy-advisory.html

Tuesday, June 3, 2008 SCRAPIE USA UPDATE JUNE 2008 NOR-98 REPORTED PA

http://nor-98.blogspot.com/2008/06/scrapie-usa-update-june-2008-nor-98.html

Monday, September 1, 2008

RE-FOIA OF DECLARATION OF EXTRAORDINARY EMERGENCY BECAUSE OF AN ATYPICAL T.S.E. (PRION DISEASE) OF FOREIGN ORIGIN IN THE UNITED STATES [No. 00-072-1] September 1, 2008

http://foiamadsheepmadrivervalley.blogspot.com/2008/09/re-foia-of-declaration-of-extraordinary.html

http://nor-98.blogspot.com/

http://scrapie-usa.blogspot.com/

CHRONIC WASTING DISEASE CWD (typical and atypical strains)

DOI: 10.3201/eid1509.090253 Suggested citation for this article: Race B, Meade-White KD, Miller MW, Barbian KD, Rubenstein R, LaFauci G, et al.

Susceptibilities of nonhuman primates to chronic wasting disease.

Emerg Infect Dis. 2009 Sep; [Epub ahead of print] Susceptibilities of Nonhuman Primates to Chronic Wasting Disease Brent Race,1 Kimberly D. Meade-White,1 Michael W. Miller, Kent D. Barbian, Richard Rubenstein, Giuseppe LaFauci, Larisa Cervenakova, Cynthia Favara, Donald Gardner, Dan Long, Michael Parnell, James Striebel, Suzette A. Priola, Anne Ward, Elizabeth S. Williams,2 Richard Race,3 and Bruce Chesebro3 Author affiliations: Rocky Mountain Laboratories, Hamilton, Montana, USA (B. Race, K.D. Meade-White, K.D. Barbian, C. Favara, D. Gardner, D. Long, M. Parnell, J. Striebel, S.A. Priola, A. Ward, R. Race, B. Chesebro); Colorado Division of Wildlife, Fort Collins, Colorado, USA (M.W. Miller); State University of New York Downstate Medical Center, Brooklyn, New York, USA (R. Rubenstein); New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA (G. LaFauci); American Red Cross, Rockville, Maryland, USA (L. Cervenakova); and University of Wyoming, Laramie, Wyoming, USA (E.S. Williams) 1These authors contributed equally to this article. 2Deceased. 3Co-senior authors.

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. CWD was inoculated into these 2 species by intracerebral and oral routes. After intracerebral inoculation of squirrel monkeys, 7 of 8 CWD isolates induced a clinical wasting syndrome within 33–53 months. The monkeys’ brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. After oral exposure, 2 squirrel monkeys had PrPres in brain, spleen, and lymph nodes at 69 months postinfection. In contrast, cynomolgus macaques have not shown evidence of clinical disease as of 70 months postinfection. Thus, these 2 species differed in susceptibility to CWD. Because humans are evolutionarily closer to macaques than to squirrel monkeys, they may also be resistant to CWD.

Page 1 of 21

snip...

Oral Infection of Squirrel Monkeys

To test a more natural route of infection, we exposed squirrel monkeys orally to CWD. Of the 15 exposed squirrel monkeys, 1 (no. 345) was found dead in its cage at 69 mpi; it had shown no neurologic signs or weakness. Western blot results indicated PrPres in brain, spleen, and lymph nodes (Figure 2, panel D). The level of PrPres in the brain of monkey 345 was comparable with that in end-stage intracerebrally inoculated monkeys; body weight at necropsy indicated a 33% decrease over the final 10 months. The high levels of PrPres and the severe wasting indicate that CWD infection could have been the cause of death. A second monkey, 303, was euthanized at 69 mpi because of suspicion of TSE after 2 weeks of progressive weakness, wasting, and eventual anorexia. PrPres analysis confirmed PrPres in brain (Figure 2, panel D), spleen, and lymph nodes. For monkeys 303 and 345, levels of PrPres in the lymph nodes and spleens were 10–100-fold lower than those in brain.

Two other orally infected monkeys were euthanized during the first 69 mpi (Table 2). Monkey 301 was euthanized at 39 mpi, after rapid onset of lethargy and anorexia that led to severe dehydration. Results of Western blot analysis for PrPres were negative in brain (Figure 1, panel B), spleen, lymph nodes, heart, skeletal muscle, duodenum, jejunum, ileum, colon, salivary gland, kidney, lung, and tonsil. However, immunohistochemical analysis detected PrPres in the

Page 7 of 21

spleen and 1 mesenteric lymph node from this monkey, indicating a low level of infection (Figure 3, panels J,K). Monkey 614 was euthanized at 44 mpi because it did not recover from anesthesia related to routine tuberculosis screening. Neither Western blot nor immunohistochemical analysis detected PrPres in brain, spleen, or lymph nodes of this monkey.

Infection of Cynomolgus Macaques

We inoculated cynomolgus macaques both orally and intracerebrally with 3 CWD inocula representing elk, mule deer, and white-tailed deer (Table 3). Of the cynomolgus macaques, 1 (no. 609) was euthanized at 48 mpi after it became aggressive. Brain (Figure 2, panel B), spinal cord, spleen, and lymph nodes were negative for PrPres by Western blot and immunohistochemical analysis. All remaining CWD-inoculated cynomolgus monkeys are currently (at 70 mpi) neurologically asymptomatic and have stable or increased body weights.

Sequences

Amino acid substitutions in PrP can alter susceptibility to TSE agents, including CWD (18,29,30). To determine whether the lack of susceptibility in several intracerebrally inoculated squirrel monkeys (Table 1) was caused by PrP gene polymorphisms, we sequenced the PrP genes from 23 squirrel monkeys. When compared with published squirrel monkey sequences (28,31), variation was seen at residue 164, in the number of octapeptide repeats, and at residue 19 of the signal peptide (Table 4). However, these genetic differences in PrP did not appear to account for the lack of susceptibility of monkey 310, which was infected with CWD genotype A, because this genotype was also found in 5 of the CWD-positive monkeys. Because we were not able to sequence PrP of monkey 628, we could not assess the role of PrP variation in the lack of disease.

Infectivity of CWD-infected Squirrel Monkey Tissues in PrP Transgenic Mice

To determine whether passage of CWD in squirrel monkeys altered the tropism of the infectious agent, we inoculated tgDeerPrP mice and tg mice expressing human PrP (lines 66 and RM) intracerebrally with tissue homogenates from 3 CWD-positive squirrel monkeys (nos. 322, 308, and 301) with PrPres and from an intracerebrally inoculated cynomolgus macaque (no. 609). Clinical disease did not develop in any tgDeerPrP mice during 600–700 days (Table 5). The lack of transmission to tgDeerPrP mice from the 3 squirrel monkeys with detectable CWD PrPres indicated that either the infectivity levels were low in these squirrel monkeys or that the original cervid species tropism was altered by the passage in squirrel monkeys. Similarly, the

Page 8 of 21

lack of transmission to tg mice expressing human PrP implied that passage through squirrel monkeys did not facilitate adaptation to an agent with increased tropism for humans.

Discussion

As new CWD foci continue to emerge among cervid populations, the risk for CWD transmission to humans needs to be assessed. We used 2 monkey species and 2 routes of inoculation to test the susceptibility of primates to 8 different pools of CWD. To date, we have verified CWD in 11 of 13 intracerebrally inoculated squirrel monkeys; average incubation period was 41 months (range 33–53 months). Using a single CWD pool, Marsh et al. noted infection in 2 of 2 squirrel monkeys 31–34 months after intracerebral inoculation (13). Intracerebral inoculation of squirrel monkeys with other TSE agents, including kuru, variant CJD, sporadic CJD, and sheep scrapie, had incubation periods of ˜24 months and attack rates of ˜100% (14,15,32). The extended incubation periods and lower attack rates for our squirrel monkeys may result from a partial species barrier to CWD.

The signs of wasting syndrome in CWD-infected monkeys were similar to those of CWD infection in cervids, in which loss of body condition is nearly always a major component of infection and neurologic deficits vary (2). The correlation of clinical signs between CWD in cervids and squirrel monkeys suggests that CWD might affect a common brain region in each species. We observed PrPres deposition in squirrel monkeys primarily in the frontal lobe of the cerebral cortex, claustrum, putamen, and thalamus. Cervids typically have the most abundant and predictable PrPres in the dorsal motor vagus nucleus (obex), olfactory cortex, and diencephalon (including thalamus, hypothalamus, metathalamus, and epithalamus) (2,33). A plausible hypothesis could be that disruption of regions within the hypothalamus and thalamus leads to a metabolic imbalance, resulting in a severe wasting syndrome. We did not observe a strong correlation between infectivity titer inoculated and attack incidence or incubation period (Table 1). One potential explanation is that the variation in speed of disease progression might not be relevant given the low number of animals in each group. A second possibility is that our squirrel monkeys varied at PrP alleles that may affect CWD susceptibility. However, analysis of 23 squirrel monkeys showed no PrP sequence differences

Page 9 of 21

correlating with susceptibility to CWD (Tables 1, 2, 4). A third possibility is that genes other than the gene for PrP might influence CWD susceptibility.

For humans, eating infected or contaminated tissue is a likely route of CWD exposure. In other animal models, oral transmission of TSE is generally 1,000-fold less effective than direct intracerebral challenge and results in longer incubation periods and lower efficiency of disease transmission. In our oral transmission experiments, we found evidence of CWD infection in 3 monkeys at >52 mpi; 2 at 69 mpi had abundant PrPres in brain and lower levels in spleen and lymph nodes, and 1 euthanized at 39 mpi had PrPres in lymphatic tissues only. Thus, transmission seems to be slower by the oral route than by the intracerebral route, and other orally infected monkeys may be affected in the future.

Cynomolgus macaques are evolutionarily closer to humans than are squirrel monkeys (17). At nearly 6 years postinoculation, no macaques have shown clinical signs of CWD. Intracerebral inoculation of cynomolgus macaques with BSE causes disease in 3 years; human variant CJD requires 2–3 years, and human sporadic CJD requires 5 years (16,34). However, oral inoculation of cynomolgus macaques with BSE agent required a minimum of 5 years before clinical disease was observed (35). Therefore, we cannot rule out CWD transmission to cynomolgus macaques.

The PrP gene sequence can influence cross-species transmission of prion disease. Therefore, we compared squirrel monkey and cynomolgus macaque PrP gene sequences to look for differences that might account for different susceptibilities of these monkeys to CWD. In the PrP gene excluding the signal peptide, deer differed from squirrel monkeys at 17 residues and from cynomolgus macaques at 16 residues, but 14 of these differing residues were identical in squirrel monkeys and macaques (Figure 4). Therefore, there are only 2 residues in cynomolgus macaques (100 and 108) and 3 residues in squirrel monkeys (56, 159 and 182) at which these monkeys differ from deer and also from each other. These residues might play a role in susceptibility differences seen in our study. Human exposure to CWD-infected cervids in past decades is likely. The highest levels of prion infectivity are present in the central nervous system and lymphatic tissues of CWD-infected cervids; contamination of knives, saws, and muscles with these tissues can easy occur when processing game. Despite the likelihood of exposures, epidemiologic studies of humans

Page 10 of 21

living in CWD-endemic areas of Colorado and Wyoming during 1979–2001 have not shown any increases in human TSE cases (36,37). Ongoing studies by the Colorado Department of Public Health and Environmental Human Prion Disease Surveillance Program, in conjunction with the University of Colorado School of Medicine, have also concluded that no convincing cases of CWD transmission to humans have been detected in Colorado (38). However, if CWD in humans appears like a wasting syndrome similar to that observed in the squirrel monkeys in our study, affected persons might receive a diagnosis of a metabolic disorder and never be tested for TSE. Fortunately, additional laboratory data are consistent with the epidemiologic data, and these results support the conclusion that a species barrier protects humans from CWD infection (11–13,20,36,37).

http://www.cdc.gov/eid/content/15/9/pdfs/09-0253.pdf

Thursday, September 10, 2009

Experimental oral transmission of CWD to red deer (Cervus elaphus elaphus): early detection and late stage distribution of protease-resistant protein

http://chronic-wasting-disease.blogspot.com/2009/09/experimental-oral-transmission-of.html

Thursday, September 24, 2009

Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer

http://chronic-wasting-disease.blogspot.com/2009/09/validation-of-use-of-rectoanal-mucosa.html

Saturday, May 16, 2009

Chronic Wasting Disease Herd Certification Program Document ID APHIS-2006-0118-0096 APHIS-2006-0118-0096

http://chronic-wasting-disease.blogspot.com/2009/05/chronic-wasting-disease-herd.html

Sunday, April 12, 2009

CWD UPDATE Infection Studies in Two Species of Non-Human Primates and one Environmental reservoir infectivity study and evidence of two strains

P35

ADAPTATION OF CHRONIC WASTING DISEASE (CWD) INTO HAMSTERS, EVIDENCE OF A WISCONSIN STRAIN OF CWD

http://chronic-wasting-disease.blogspot.com/2009/04/cwd-update-infection-studies-in-two.html

TO ASSUME that CWD transmission to humans will only look like nvCJD, and not sporadic CJD or any of it's sub-types, is incorrect, not scientific. ...TSS

*** twenty-seven CJD patients who regularly consumed venison were reported to the Surveillance Center***,

snip...

full text ;

http://chronic-wasting-disease.blogspot.com/2008/04/prion-disease-of-cervids-chronic.html

http://chronic-wasting-disease.blogspot.com/2008/04/prion-disease-of-cervids-chronic.html

http://www.mad-cow.org/00/sep00_sci_news.html#bbb

From: TSS
Subject: CWD aka MAD DEER/ELK TO HUMANS ???
Date: September 30, 2002 at 7:06 am PST

From: "Belay, Ermias"
To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"
Sent: Monday, September 30, 2002 9:22 AM
Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.

That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.

Ermias Belay, M.D. Centers for Disease Control and Prevention

-----Original Message----- From: Sent: Sunday, September 29, 2002 10:15 AM To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask] Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS

snip...see full text ;

http://chronic-wasting-disease.blogspot.com/2008/08/cwd-stakeholder-advisory-group.html

CHRONIC WASTING DISEASE

http://chronic-wasting-disease.blogspot.com/

Saturday, December 01, 2007

Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model

Volume 13, Number 12–December 2007 Research

http://transmissible-mink-encephalopathy.blogspot.com/2007_12_01_archive.html

TRANSMISSIBLE MINK ENCEPHALOPATHY (TME)

http://transmissible-mink-encephalopathy.blogspot.com/

FELINE SPONGIFORM ENCEPHALOPATHY (FSE)

(please note, the only reason FSE is not detected in the USA, is the lack of surveillance i.e. don't look, don't find. ...TSS)

http://felinespongiformencephalopathyfse.blogspot.com/

CANINE SPONGIFORM ENCEPHALOPATHY (CSE) ???

(please note again, the only reason a TSE has not been _confirmed_ in a dog, i.e. don't look, don't find)

HOUND STUDY

AS implied in the Inset 25 we must not _ASSUME_ that transmission of BSE to other species will invariably present pathology typical of a scrapie-like disease.

snip…

http://www.bseinquiry.gov.uk/files/yb/1991/01/04004001.pdf

2005 DEFRA Department for Environment, Food & Rural Affairs

Area 307, London, SW1P 4PQ Telephone: 0207 904 6000 Direct line: 0207 904 6287 E-mail: h.mcdonagh.defra.gsi.gov.uk

GTN: FAX:

Mr T S Singeltary P.O. Box 42 Bacliff Texas USA 77518

21 November 2001

Dear Mr Singeltary

TSE IN HOUNDS

Thank you for e-mail regarding the hounds survey. I am sorry for the long delay in responding.

As you note, the hound survey remains unpublished. However the Spongiform Encephalopathy Advisory Committee (SEAC), the UK Government’s independent Advisory Committee on all aspects related to BSE-like disease, gave the hound study detailed consideration at their meeting in January 1994. As a summary of this meeting published in the BSE inquiry noted, the Committee were clearly concerned about the work that had been carried out, concluding that there had clearly been problems with it, particularly the control on the histology, and that it was more or less inconclusive. However was agreed that there should be a re-evaluation of the pathological material in the study.

Later, at their meeting in June 95, The Committee re-evaluated the hound study to see if any useful results could be gained from it. The Chairman concluded that there were varying opinions within the Committee on further work. It did not suggest any further transmission studies and thought that the lack of clinical data was a major weakness.

Overall, it is clear that SEAC had major concerns about the survey as conducted. As a result it is likely that the authors felt that it would not stand up to r~eer review and hence it was never published. As noted above, and in the detailed minutes of the SEAC meeting in June 95, SEAC considered whether additional work should be performed to examine dogs for evidence of TSE infection. Although the Committee had mixed views about the merits of conducting further work, the Chairman noted that when the Southwood Committee made their recommendation to complete an assessment of possible spongiform disease in dogs, no TSEs had been identified in other species and hence dogs were perceived as a high risk population and worthy of study. However subsequent to the original recommendation, made in 1990, a number of other species had been identified with TSE ( e.g. cats) so a study in hounds was less

critical. For more details see-

http://www.bseinquiry.gov.uk/files/yb/1995/06/21005001.pdf

As this study remains unpublished, my understanding is that the ownership of the data essentially remains with the original researchers. Thus unfortunately, I am unable to help with your request to supply information on the hound survey directly. My only suggestion is that you contact one of the researchers originally involved in the project, such as Gerald Wells. He can be contacted at the following address.

Dr Gerald Wells, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey, KT 15 3NB, UK

You may also wish to be aware that since November 1994 all suspected cases of spongiform encephalopathy in animals and poultry were made notifiable. Hence since that date there has been a requirement for vets to report any suspect SE in dogs for further investigation. To date there has never been positive identification of a TSE in a dog.

I hope this is helpful

Yours sincerely 4

HUGH MCDONAGH BSE CORRESPONDENCE SECTION

IN CONFIDENCE

CONCEPT NOT FOR FURTHER STUDY OF MATERIAL OBTAINED IN A SURVEY OF HOUNDS FOR EVIDENCE OF A SCRAPIE-LIKE SPONGIFORM ENCEPHALOPATHY (SE)

snip…

b) Fibrillar material closely similar to SAF, found in BSE/Scrapie, was observed in 19 (4.3%) cases, all of which were hounds > 7 years of age. 14/19 of these suspected SAF results correlated with cases in the unresolveable histopathological category.

snip…

The following proposals address the hypothesis that the hound survey observations represent a PrP related or scrapie-like disease of dogs in which the pathological response, and possible the spread of infectivity, is neuroanatomically localized. By inference this could also mean that the disorder is clinically silent and non-progressive.

http://www.bseinquiry.gov.uk/files/yb/1995/02/09001001.pdf

http://www.mad-cow.org/00/aug00_late_news.html#ggg

http://www.kxnet.com/getForumPost.asp?ArticleId=113652

http://www.keeneequinox.com/home/index.cfm?event=displayArticleComments&ustory_id=4d8de1c2-fa09-42dc-958a-7e94e16e22db

PET FOODS MAD CATS AND MAD DOGS BSE/TSEs

worse still, there is serious risk the media could get to hear of such a meeting…

snip…

Crushed heads (which inevitably involve brain and spinal cord material) are used to a limited extent but will also form one of the constituent raw materials of meat and bone meal, which is used extensively in pet food manufacturer…

http://www.bseinquiry.gov.uk/files/yb/1989/03/17004001.pdf

THIS DATA CAN BE LOCATED UNDER FSE URL AS WELL ;

http://felinespongiformencephalopathyfse.blogspot.com/

PIGS AND TSE ?

Thursday, October 15, 2009

Transmissibility studies of vacuolar changes in the rostral colliculus of pigs

http://madporcinedisease.blogspot.com/

CREUTZFELDT JAKOB DISEASE AND OTHER HUMAN TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY

Thursday, November 05, 2009

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

http://creutzfeldt-jakob-disease.blogspot.com/2009/11/incidence-and-spectrum-of-sporadic.html

Friday, October 23, 2009

Creutzfeldt-Jakob Disease Surveillance Texas Data for Reporting Years 2000-2008

http://cjdtexas.blogspot.com/2009/10/creutzfeldt-jakob-disease-surveillance.html

BSE (Mad Cow) Update: Do Reports of sCJD Clusters Matter?

snip... see full text ;

http://cjdtexas.blogspot.com/

JOURNAL OF NEUROLOGY

MARCH 26, 2003

Send Post-Publication Peer Review to journal:

Re: RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob

disease in the United States

Email Terry S. Singeltary:

mhtml:%7B33B38F65-8D2E-434D-8F9B-8BDCD77D3066%7Dmid://00000748/!x-usc:mailto:flounder@wt.net

I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to comment on the CDC's attempts to monitor the occurrence of emerging forms of CJD. Asante, Collinge et al [1] have reported that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest sporadic CJD. However, CJD and all human TSEs are not reportable nationally. CJD and all human TSEs must be made reportable in every state and internationally. I hope that the CDC does not continue to expect us to still believe that the 85%+ of all CJD cases which are sporadic are all spontaneous, without route/source. We have many TSEs in the USA in both animal and man. CWD in deer/elk is spreading rapidly and CWD does transmit to mink, ferret, cattle, and squirrel monkey by intracerebral inoculation. With the known incubation periods in other TSEs, oral transmission studies of CWD may take much longer. Every victim/family of CJD/TSEs should be asked about route and source of this agent. To prolong this will only spread the agent and needlessly expose others. In light of the findings of Asante and Collinge et al, there should be drastic measures to safeguard the medical and surgical arena from sporadic CJDs and all human TSEs. I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?

http://www.neurology.org/cgi/eletters/60/2/176#535

LANCET INFECTIOUS DISEASE JOURNAL

Volume 3, Number 8 01 August 2003

Newsdesk

Tracking spongiform encephalopathies in North America

Xavier Bosch

My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem.

49-year-old Singeltary is one of a number of people who have remained largely unsatisfied after being told that a close relative died from a rapidly progressive dementia compatible with spontaneous Creutzfeldt-Jakob disease (CJD). So he decided to gather hundreds of documents on transmissible spongiform encephalopathies (TSE) and realised that if Britons could get variant CJD from bovine spongiform encephalopathy (BSE), Americans might get a similar disorder from chronic wasting disease (CWD)the relative of mad cow disease seen among deer and elk in the USA. Although his feverish search did not lead him to the smoking gun linking CWD to a similar disease in North American people, it did uncover a largely disappointing situation.

Singeltary was greatly demoralised at the few attempts to monitor the occurrence of CJD and CWD in the USA. Only a few states have made CJD reportable. Human and animal TSEs should be reportable nationwide and internationally, he complained in a letter to the Journal of the American Medical Association (JAMA 2003; 285: 733). I hope that the CDC does not continue to expect us to still believe that the 85% plus of all CJD cases which are sporadic are all spontaneous, without route or source.

Until recently, CWD was thought to be confined to the wild in a small region in Colorado. But since early 2002, it has been reported in other areas, including Wisconsin, South Dakota, and the Canadian province of Saskatchewan. Indeed, the occurrence of CWD in states that were not endemic previously increased concern about a widespread outbreak and possible transmission to people and cattle.

To date, experimental studies have proven that the CWD agent can be transmitted to cattle by intracerebral inoculation and that it can cross the mucous membranes of the digestive tract to initiate infection in lymphoid tissue before invasion of the central nervous system. Yet the plausibility of CWD spreading to people has remained elusive.

Part of the problem seems to stem from the US surveillance system. CJD is only reported in those areas known to be endemic foci of CWD. Moreover, US authorities have been criticised for not having performed enough prionic tests in farm deer and elk.

Although in November last year the US Food and Drug Administration issued a directive to state public-health and agriculture officials prohibiting material from CWD-positive animals from being used as an ingredient in feed for any animal species, epidemiological control and research in the USA has been quite different from the situation in the

UK and Europe regarding BSE.

Getting data on TSEs in the USA from the government is like pulling teeth, Singeltary argues. You get it when they want you to have it and only what they want you to have.Norman Foster, director of the Cognitive Disorders Clinic at the University of Michigan (Ann Arbor, MI, USA), says that current surveillance of prion disease in people in the USA is inadequate to detect whether CWD is occurring in human beings; adding that, the cases that we know about are reassuring, because they do not suggest the appearance of a new variant of CJD in the USA or atypical features in patients that might be exposed to CWD. However, until we establish a system that identifies and analyses a high proportion of suspected prion disease cases we will not know for sure. The USA should develop a system modelled on that established in the UK, he points out.

Ali Samii, a neurologist at Seattle VA Medical Center who recently reported the cases of three hunterstwo of whom were friendswho died from pathologically confirmed CJD, says that at present there are insufficient data to claim transmission of CWD into humans; adding that [only] by asking [the questions of venison consumption and deer/elk hunting] in every case can we collect suspect cases and look into the plausibility of transmission further. Samii argues that by making both doctors and hunters more aware of the possibility of prions spreading through eating venison, doctors treating hunters with dementia can consider a possible prion disease, and doctors treating CJD patients will know to ask whether they ate venison. CDC spokesman Ermias Belay says that the CDC will not be investigating the [Samii] cases because there is no evidence that the men ate CWD-infected meat. He notes that although the likelihood of CWD jumping the species barrier to infect humans cannot be ruled out 100% and that [we] cannot be 100% sure that CWD does not exist in humans & the data seeking evidence of CWD transmission to humans have been very limited.

http://www.thelancet.com/journals/laninf/article/PIIS1473309903007151/%20fulltext

he complained in a letter to the Journal of the American Medical Association (JAMA 2003; 285: 733).

I hope that the CDC does not continue to expect us to still believe that the 85% plus of all CJD cases which are sporadic are all spontaneous, without route or source.<<< href="http://jama.ama-assn.org/cgi/content/extract/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT">http://jama.ama-assn.org/cgi/content/extract/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

http://jama.ama-assn.org/cgi/content/full/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

2 January 2000

British Medical Journal

U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well

http://www.bmj.com/cgi/eletters/320/7226/8/b#6117

15 November 1999

British Medical Journal

vCJD in the USA * BSE in U.S.

http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406

THE PATHOLOGICAL PROTEIN

BY Philip Yam

Yam Philip Yam News Editor Scientific American http://www.sciam.com/

http://www.thepathologicalprotein.com/

SEE REVISITING SPORADIC CJD BY PHILIP YAM THE PATHOLOGICAL PROTEIN

Answering critics like Terry Singeltary, who feels that the U.S. undercounts CJD, Schonberger conceded that the current surveillance system has errors but stated that most of the errors will be confined to the older population. ...

http://books.google.com/books?id=ePbrQNFrHtoC&pg=PA224&lpg=PA224&dq=pathological+protein+philip+yam+singeltary&source=bl&ots=um-LytTT2E&sig=hQVJotGvhvffOsN2fsIDfk2SHXw&hl=en&ei=CaWBSrDLCIKUtgeg_eTVCg&sa=X&oi=book_result&ct=result&resnum=1#v=onepage&q=&f=false

Sunday, August 10, 2008

A New Prionopathy OR more of the same old BSe and sporadic CJD

http://creutzfeldt-jakob-disease.blogspot.com/2008/08/new-prionopathy-or-more-of-same-old-bse.html

2008

The statistical incidence of CJD cases in the United States has been revised to reflect that there is one case per 9000 in adults age 55 and older. Eighty-five percent of the cases are sporadic, meaning there is no known cause at present.

http://www.cjdfoundation.org/fact.html

Friday, November 30, 2007

CJD QUESTIONNAIRE USA CWRU AND CJD FOUNDATION

http://cjdquestionnaire.blogspot.com/

IT ALL STARTED, LEGALLY, RIGHT HERE, the legal trading of ALL TSE's, globally $$$

Docket APHIS-2006-0026 Docket Title Bovine Spongiform Encephalopathy; Animal Identification and Importation of Commodities Docket Type Rulemaking Document APHIS-2006-0026-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions, Identification of Ruminants and Processing and Importation of Commodities Public Submission APHIS-2006-0026-0012 Public Submission Title Comment from Terry S Singletary

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801e47e1

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028 Public Submission Title Comment from Terry S Singletary

Comment 2006-2007 USA AND OIE POISONING GLOBE WITH BSE MRR POLICY

THE USA is in a most unique situation, one of unknown circumstances with human and animal TSE. THE USA has the most documented TSE in different species to date, with substrains growing in those species (BSE/BASE in cattle and CWD in deer and elk, there is evidence here with different strains), and we know that sheep scrapie has over 20 strains of the typical scrapie with atypical scrapie documented and also BSE is very likely to have passed to sheep. all of which have been rendered and fed back to animals for human and animal consumption, a frightening scenario. WE do not know the outcome, and to play with human life around the globe with the very likely TSE tainted products from the USA, in my opinion is like playing Russian roulette, of long duration, with potential long and enduring consequences, of which once done, cannot be undone. These are the facts as I have come to know through daily and extensive research of TSE over 9 years, since 12/14/97. I do not pretend to have all the answers, but i do know to continue to believe in the ukbsenvcjd only theory of transmission to humans of only this one strain from only this one TSE from only this one part of the globe, will only lead to further failures, and needless exposure to humans from all strains of TSE, and possibly many more needless deaths from TSE via a multitude of proven routes and sources via many studies with primates and rodents and other species.

MY personal belief, since you ask, is that not only the Canadian border, but the USA border, and the Mexican border should be sealed up tighter than a drum for exporting there TSE tainted products, until a validated, 100% sensitive test is available, and all animals for human and animal consumption are tested. all we are doing is the exact same thing the UK did with there mad cow poisoning when they exported it all over the globe, all the while knowing what they were doing. this BSE MRR policy is nothing more than a legal tool to do just exactly what the UK did, thanks to the OIE and GW, it's legal now. and they executed Saddam for poisoning ???

go figure. ...

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8151

Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028.1 Public Submission Title Attachment to Singletary comment

January 28, 2007

Greetings APHIS,

I would kindly like to submit the following to ;

BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01

http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f8152&disposition=attachment&contentType=msw8

Monday, October 26, 2009

MAD COW DISEASE, AND U.S. BEEF TRADE

MAD COW DISEASE, CJD, TSE, SOUND SCIENCE, COMMERCE, AND SELLING YOUR SOUL TO THE DEVIL

http://usdameatexport.blogspot.com/2009/10/mad-cow-disease-and-us-beef-trade.html

NOW, consider all these animal TSEs, consider all these animals used in food for human and animals, consider all the exposed, then consider the 'pass if forward' modes of transmission, and an incubation period for up to 5 decades.

Thank You,

with kindest regards,

I am sincerely,

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518

FREE Kim Min-sun, she is correct about mad cow fears from USDA BEEF

2009-08-22T16:36:00.000-07:00

Sent: Saturday, August 22, 2009 3:18 PM

Subject: FREE Kim Min-sun, she is correct about mad cow fears from USDA BEEF

Kim Min-sun is correct about mad cow fears from USDA BEEF

WHOM is to say, whether or not, one would rather die fast from cyanide, or slow from mad cow disease. some would rather die in a fast mode, than say slowly, an agonizing death, from Creutzfeldt Jakob Disease ??? IN a free society, would one not have the right of free speech to voice that opinion ???

WHOM is to say, that some sub-types of the CJD in the USA, is not from the atypical mad cow disease in the USA ???

WHAT DID ONE OF THE TOP USA SCIENTIST ON PRIONS AND TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY SAY ABOUT USA BEEF ???

Kim Min-sun, who allegedly "misled the public to boycott U.S. beef consumption", did NOT mislead anyone. the fact of the matter is, the Korean Government, and it's people, are being mislead by the USA government i.e. USDA. the proof is here, you only need to watch this video and you will see whom has mislead whom...

SEE THE DAMNING VIDEO NOW AT THE BOTTOM OF THE BLOG BELOW ;

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html

DAMNING TESTIMONY FROM STANLEY PRUSINER THE NOBEL PEACE PRIZE WINNER ON PRIONS SPEAKING ABOUT ANN VENEMAN

''nobody has ever ask''

''they dont want our comment''

''they don't want to know, the don't care''

''i have tried repeatedly''

''level of absolute ignorance''

''Entire policy was driven...heard from mr. laycraft, so now, after time has passed, it's ok for Canada, cattle under 30 month, to the USA, THAT'S ALL THAT MATTERED!

PRUSINER ASKED : IF FROM YOUR TESTIMONY, A DEMONSTRATED THREAT TO PUBLIC HEATH ?

''yes, i think prions are bad to eat, and you can die from them''

http://maddeer.org/video/embedded/prusinerclip.html

Saturday, June 13, 2009

Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009

http://cjdusa.blogspot.com/2009/06/monitoring-occurrence-of-emerging-forms.html

Tuesday, August 11, 2009

Characteristics of Established and Proposed Sporadic Creutzfeldt-Jakob Disease Variants

http://creutzfeldt-jakob-disease.blogspot.com/2009/08/characteristics-of-established-and.html

Tuesday, July 14, 2009

U.S. Emergency Bovine Spongiform Encephalopathy Response Plan Summary and BSE Red Book Date: February 14, 2000 at 8:56 am PST

WHERE did we go wrong $$$

http://madcowtesting.blogspot.com/2009/07/us-emergency-bovine-spongiform.html

Tuesday, August 18, 2009

BSE-The Untold Story - joe gibbs and singeltary 1999 - 2009

http://madcowusda.blogspot.com/2009/08/bse-untold-story-joe-gibbs-and.html

Sunday, August 09, 2009

CJD...Straight talk with...James Ironside...and...Terry Singeltary... 2009

http://creutzfeldt-jakob-disease.blogspot.com/2009/08/cjdstraight-talk-withjames.html

Atypical BSE North America Update February 2009

http://bse-atypical.blogspot.com/2009/02/atypical-bse-north-america-update.html

Sunday, December 28, 2008

MAD COW DISEASE USA DECEMBER 28, 2008 an 8 year review of a failed and flawed policy

http://bse-atypical.blogspot.com/2008/12/mad-cow-disease-usa-december-28-2008-8.html

Wednesday, August 20, 2008

Bovine Spongiform Encephalopathy Mad Cow Disease typical and atypical strains, was there a cover-up ?

http://bse-atypical.blogspot.com/2008/08/bovine-spongiform-encephalopathy-mad.html

Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical scrapie. Emerg Infect Dis. 2009 Aug; [Epub ahead of print]

http://nor-98.blogspot.com/2009/07/transgenic-mice-expressing-porcine.html

Transmissible mink encephalopathy - review of the etiology

http://transmissible-mink-encephalopathy.blogspot.com/2009/07/transmissible-mink-encephalopathy.html

Wednesday, July 1, 2009

Nor98 scrapie identified in the United States J Vet Diagn Invest 21:454-463 (2009)

http://nor-98.blogspot.com/2009/07/nor98-scrapie-identified-in-united.html

Thursday, March 19, 2009

Chronic Wasting Disease Prions in Elk Antler Velvet (Nutritional Supplements and CJD)

http://chronic-wasting-disease.blogspot.com/2009/03/chronic-wasting-disease-prions-in-elk.html

Monday, June 01, 2009 Biochemical typing of pathological prion protein in aging cattle with BSE

SOMETHING TO PONDER ???

O.K. confusious asks, IF all these new atypical BSEs i.e. new strains of mad cow disease is just an 'OLD COW PRION DISEASE', why then can not the 'old human prion disease' such as the sporadic CJD, be from an 'old cow prion disease', same as the nvCJD 'young people mad cow disease' (which also happens in 74 year old), but why cannot the 'old cow prion diseases', i.e. l-BSE, h-BSE, and ibncBSE, cause the 'old people prion disease', which looks like sporadic CJD. seems that is what some of the pathology is showing ???

OH, that probably makes too much sense, and that the only answer could be that it's all just a happenstance of bad luck and or a spontaneous event, that just happens out of the clear blue sky $$$

IF this is the case, then where are all the SPONTANEOUS BSE CASES OF MAD COW DISEASE IN THE U.S.A., AND WHERE HAVE THEY BEEN BURIED IN THE USA OVER THE LAST 25 YEARS ???

http://bse-atypical.blogspot.com/2009/06/biochemical-typing-of-pathological.html

WHAT ABOUT THOSE USDA FDA MAD COW FEED FIREWALLS, THAT PREVENTS MAD COW DISEASE IN THE USA $$$

THE AUGUST 4, 1997 MAD COW FEED BAN IN THE USA WAS NOTHING MORE THAN INK ON PAPER, THE PARTIAL AND VOLUNTARY FEED BAN WAS NOT ENFORCED !!! see for yourself ;

10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN COMMERCE USA 2007

Date: March 21, 2007 at 2:27 pm PST

RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINES -- CLASS II

___________________________________

PRODUCT

Bulk cattle feed made with recalled Darling's 85% Blood Meal, Flash Dried, Recall # V-024-2007

CODE

Cattle feed delivered between 01/12/2007 and 01/26/2007

RECALLING FIRM/MANUFACTURER

Pfeiffer, Arno, Inc, Greenbush, WI. by conversation on February 5, 2007.

Firm initiated recall is ongoing.

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

___________________________________

PRODUCT

Custom dairy premix products: MNM ALL PURPOSE Pellet, HILLSIDE/CDL Prot- Buffer Meal, LEE, M.-CLOSE UP PX Pellet, HIGH DESERT/ GHC LACT Meal, TATARKA, M CUST PROT Meal, SUNRIDGE/CDL PROTEIN Blend, LOURENZO, K PVM DAIRY Meal, DOUBLE B DAIRY/GHC LAC Mineral, WEST PIONT/GHC CLOSEUP Mineral, WEST POINT/GHC LACT Meal, JENKS, J/COMPASS PROTEIN Meal, COPPINI - 8# SPECIAL DAIRY Mix, GULICK, L-LACT Meal (Bulk), TRIPLE J - PROTEIN/LACTATION, ROCK CREEK/GHC MILK Mineral, BETTENCOURT/GHC S.SIDE MK-MN, BETTENCOURT #1/GHC MILK MINR, V&C DAIRY/GHC LACT Meal, VEENSTRA, F/GHC LACT Meal, SMUTNY, A- BYPASS ML W/SMARTA, Recall # V-025-2007

CODE

The firm does not utilize a code - only shipping documentation with commodity and weights identified.

RECALLING FIRM/MANUFACTURER

Rangen, Inc, Buhl, ID, by letters on February 13 and 14, 2007. Firm initiated recall is complete.

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/bbs/topics/enforce/2007/ENF00996.html

NEW URL

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm

Thursday, March 19, 2009 MILLIONS AND MILLIONS OF POUNDS OF MAD COW FEED IN COMMERCE USA WITH ONGOING 12 YEARS OF DENIAL NOW, WHY IN THE WORLD DO WE TO TALK ABOUT THIS ANYMORE $$$

http://madcowfeed.blogspot.com/2009/03/millions-and-millions-of-pounds-of-mad.html

Tuesday, July 28, 2009 MAD COW COVER-UP USA MASKED AS SPORADIC CJD

THE USDA JUNE 2004 ENHANCED BSE SURVEILLANCE PROGRAM WAS TERRIBLY FLAWED ;

CDC DR. PAUL BROWN TSE EXPERT COMMENTS 2006

The U.S. Department of Agriculture was quick to assure the public earlier this week that the third case of mad cow disease did not pose a risk to them, but what federal officials have not acknowledged is that this latest case indicates the deadly disease has been circulating in U.S. herds for at least a decade.

The second case, which was detected last year in a Texas cow and which USDA officials were reluctant to verify, was approximately 12 years old.

These two cases (the latest was detected in an Alabama cow) present a picture of the disease having been here for 10 years or so, since it is thought that cows usually contract the disease from contaminated feed they consume as calves. The concern is that humans can contract a fatal, incurable, brain-wasting illness from consuming beef products contaminated with the mad cow pathogen.

"The fact the Texas cow showed up fairly clearly implied the existence of other undetected cases," Dr. Paul Brown, former medical director of the National Institutes of Health's Laboratory for Central Nervous System Studies and an expert on mad cow-like diseases, told United Press International. "The question was, 'How many?' and we still can't answer that."

Brown, who is preparing a scientific paper based on the latest two mad cow cases to estimate the maximum number of infected cows that occurred in the United States, said he has "absolutely no confidence in USDA tests before one year ago" because of the agency's reluctance to retest the Texas cow that initially tested positive.

USDA officials finally retested the cow and confirmed it was infected seven months later, but only at the insistence of the agency's inspector general.

"Everything they did on the Texas cow makes everything USDA did before 2005 suspect," Brown said. ...snip...end

http://www.upi.com/

CDC - Bovine Spongiform Encephalopathy and Variant Creutzfeldt ... Dr. Paul Brown is Senior Research Scientist in the Laboratory of Central Nervous System ... Address for correspondence: Paul Brown, Building 36, Room 4A-05, ...

http://www.cdc.gov/ncidod/eid/vol7no1/brown.htm

PAUL BROWN COMMENT TO ME ON THIS ISSUE

Tuesday, September 12, 2006 11:10 AM

"Actually, Terry, I have been critical of the USDA handling of the mad cow issue for some years, and with Linda Detwiler and others sent lengthy detailed critiques and recommendations to both the USDA and the Canadian Food Agency." ........TSS

see full text ;

http://madcowtesting.blogspot.com/2009/07/mad-cow-cover-up-usa-masked-as-sporadic.html

Research article Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients

Bo-Yeong Choi , Su Yeon Kim , So-Young Seo , Seong Soo A An , SangYun Kim , Sang-Eun Park , Seung-Han Lee , Yun-Ju Choi , Sang-Jin Kim , Chi-Kyeong Kim , Jun-Sun Park and Young-Ran Ju

BMC Infectious Diseases 2009, 9:132doi:10.1186/1471-2334-9-132

Published: 22 August 2009

Abstract (provisional) Background Polymorphisms of the human prion protein gene (PRNP) contribute to the genetic determinants of Creutzfeldt-Jakob disease (CJD). Numerous polymorphisms in the promoter regions as well as the open reading frame of PRNP were investigated. Greater than 90% of Koreans, Chinese, and Japanese carry the homozygote 129MM codon. In Korea, polymorphisms have not been comprehensively studied, except codons 129 and 219 in PRNP among Korean CJD cases. Although polymorphisms at codons 129 and 219 play an important role in susceptibility to sporadic CJD, patients with other polymorphisms in PRNP exhibited critical distinctions of clinical symptoms.

Methods The genetic analyses of PRNP were carried out among probable CJD patients in comparison with the results from magnetic resonance imaging (MRI) and electroencephalogram (EEG).

Results The molecular analysis revealed that three mutations at codons D178N, E200K, and M232R in heterozygosity. Patients with the D178N and M232R mutations had a 129MM codon, whereas the patient with the E200K mutation showed 129MV heterozygosity. They all revealed strong 14-3-3 positive signals. The 67-year-old patient with the D178N-129M mutation showed progressive gait disturbance and dysarthria was in progress. The 58-year-old patient with the E200K mutation coupled to the 129MV codon had gait disturbance, dysarthria, agitation, and ataxic gait, and progressed rapidly to death 3 months from the first onset of symptoms. The 65-year-old patient with the M232R mutation showed rapidly progressive memory decline and gait disturbance, and died within 16 months after onset of symptoms.

Conclusions Despite differences in ethnicity, the clinical and pathological outcomes were similar to the respective mutations around the world, except absence of insomnia in D178N-129M subject.

http://www.biomedcentral.com/1471-2334/9/132/abstract

Monday, May 12, 2008

BSE YOUNGEST AGE STATISTICS UNDER 30 MONTHS

the myth that cattle under 30 months of age are free from BSE/TSE is just that, a myth, and it's a false myth !

Information released on 2 February 2005 Summary of information requested What statistics are available on cattle less than 30 months of age found to have BSE? Information released VLA has recorded approximately 100 cases of BSE in cattle of 30 months of age or under during the entire period of the BSE epidemic (1986 - 2005). The figure is approximate as for 51 of these the age is only estimated. This is because farmers did not have accurate documentation to confirm birth date. This was not a requirement at the time. We can confirm that of the 100 cases, 49 were under 30 months of age, of these the youngest case was 20 months old.

http://www.defra.gov.uk/vla/vla/vla_ati_020205.htm

Youngest confirmed case 20 Months, Oldest confirmed case 22 Years, Data valid to 01 April 2008

http://www.defra.gov.uk/vla/science/docs/sci_tse_stats_gen.pdf

BSE Youngest and oldest cases by year of onset - GB 20 months, 21 months, (8) 24 months, see complete list of younger than 30 month ;

http://www.food.gov.uk/multimedia/pdfs/otmbsestatistics.pdf

BSE Youngest Japan 21 months, 23 months

http://www.jstage.jst.go.jp/article/ehpm/10/3/130/_pdf

Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted USA Beef

By Terry S. Singeltary Sr. May 15, 2008

Straight to the Source

Web Note: This is an important commentary by Terry S. Singeltary Sr., on a recent Business Week story on the controversy in South Korea over their government's lifting on the ban on conventional (non-organic) beef, despite the fact that the USDA is still allowing slaughterhouse waste and blood and manure to be fed to cows, and refusing to test all cows at slaughter. See the Mad Cow section of the OCA website for in-depth information. Terry is a regular blogger on the OCA website on Mad Cow issues.

Ronnie Cummins

One Korean official says the probability of a human being catching a mad cow disease by eating U.S. beef is like the one of a golf player scoring a hole-in-one and then being killed by lightning.

this is typical BSe. you here industry groups comment 'your more likely to get hit by a car than die from CJD'. well, maybe so, but my mother and many more did not die from getting hit by a car, they died from CJD, my mothers being the hvCJD (confirmed), and my neighbors mother died from CJD (confirmed). the UKBSEnvCJD _only_ theory is incorrect. there are more strains of mad cow than the UK BSE in beef to nvCJD in humans in the UK. The deception by the USDA, FDA, and the Bush administration about mad cow disease, CJD, and all Transmissible Spongiform Encephalopathy over the past 8 years have been outrageous, to a point of being criminal. I am vested in nothing, but the truth.

snip...see full text ;

http://www.grassrootsnetroots.org/articles/article_12387.cfm

USDA VS KOREA typical or atypical BSe

http://usdavskorea.blogspot.com/

Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

Tons of USA Beef Suspected of Mad Cow Disease Sold KOREA

2009-04-14T09:58:00.000-07:00

04-14-2009 19:43

Tons of Beef Suspected of Mad Cow Disease Sold

By Kim Rahn Staff Reporter

About 13 tons of American beef were falsely sold as Australian products five years ago in defiance of a disposal order issued after a case of mad cow disease, or bovine spongiform encephalopathy (BSE), was reported in the United States.

The prosecution indicted two men, identified as Seon and Kim, Monday, for having hoarded the American beef from a discount store where Seon worked and having supplied it to big discount store chains and department stores.

In December 2003, when cows suspected of having the disease were found in the U.S. and Seon's company was ordered to dispose of all American beef, he allegedly destroyed seven tons and falsely reported to the company that he had destroyed the entire 29 tons in the store.

Among the remaining 22 tons, Seon delivered 12.7 tons to discount stores and department stores between August and December 2004. The two fabricated expiration dates of the products and labeled them as ``Australian beef,'' raking in 280 million won in revenue. The products sold out.

Seon claimed that they did not distribute about 10 tons of the remaining products, but prosecutors suspect they did, requesting a tax agency audit Kim's company.

The prosecution is considering expanding the investigation into other meat distributors to search for similar cases.

mhtml:%7B33B38F65-8D2E-434D-8F9B-8BDCD77D3066%7Dmid://00000162/!x-usc:mailto:rahnita@koreatimes.co.kr

http://www.koreatimes.co.kr/www/news/nation/2009/04/117_43177.html

Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted USA Beef By Terry S. Singeltary Sr. May 15, 2008 Straight to the Source

Web Note: This is an important commentary by Terry S. Singeltary Sr., on a recent Business Week story on the controversy in South Korea over their government's lifting on the ban on conventional (non-organic) beef, despite the fact that the USDA is still allowing slaughterhouse waste and blood and manure to be fed to cows, and refusing to test all cows at slaughter. See the Mad Cow section of the OCA website for in-depth information. Terry is a regular blogger on the OCA website on Mad Cow issues.

Ronnie Cummins

http://www.organicconsumers.org/articles/article_12387.cfm

http://www.fpif.org/fpiftxt/3940

http://www.testcowsnow.com/export-of-beef-and-beef-products-to-korea-usda-fsis-notice-expires-7109-opi-oppd

http://usdavskorea.blogspot.com/2008/05/usda-vs-korea-typical-or-atypical-bse.html

*** 2009 ***

P26

TRANSMISSION OF ATYPICAL BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN HUMANIZED MOUSE MODELS

Liuting Qing1, Fusong Chen1, Michael Payne1, Wenquan Zou1, Cristina Casalone2, Martin Groschup3, Miroslaw Polak4, Maria Caramelli2, Pierluigi Gambetti1, Juergen Richt5*, and Qingzhong Kong1 1Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; 2CEA, Istituto Zooprofilattico Sperimentale, Italy; 3Friedrich-Loeffler-Institut, Germany; 4National Veterinary Research Institute, Poland; 5Kansas State University, Diagnostic Medicine/Pathobiology Department, Manhattan, KS 66506, USA. *Previous address: USDA National Animal Disease Center, Ames, IA 50010, USA

Classical BSE is a world-wide prion disease in cattle, and the classical BSE strain (BSE-C) has led to over 200 cases of clinical human infection (variant CJD). Two atypical BSE strains, BSE-L (also named BASE) and BSE-H, have been discovered in three continents since 2004. The first case of naturally occurring BSE with mutated bovine PrP gene (termed BSE-M) was also found in 2006 in the USA. The transmissibility and phenotypes of these atypical BSE strains/isolates in humans were unknown. We have inoculated humanized transgenic mice with classical and atypical BSE strains (BSE-C, BSE-L, BSE-H) and the BSE-M isolate. We have found that the atypical BSE-L strain is much more virulent than the classical BSE-C. The atypical BSE-H strain is also transmissible in the humanized transgenic mice with distinct phenotype, but no transmission has been observed for the BSE-M isolate so far.

III International Symposium on THE NEW PRION BIOLOGY: BASIC SCIENCE, DIAGNOSIS AND THERAPY 2 - 4 APRIL 2009, VENEZIA (ITALY)

http://www.istitutoveneto.it/prion_09/Abstracts_09.pdf

Research Project: GENETIC AND BIOLOGICAL DETERMINANTS OF RESPIRATORY DISEASE SUSCEPTIBILITY Location: Animal Health Systems Research

Title: Association of a bovine prion gene haplotype with atypical BSE

Author

Clawson, Michael

Submitted to: Meeting Abstract Publication Type: Abstract Publication Acceptance Date: December 2, 2008 Publication Date: January 1, 2009 Citation: Clawson, M.L. 2009. Association of a bovine prion gene haplotype with atypical BSE [abstract]. Plant and Animal Genomes XVII Conference. Abstract No. W091. Available:

http://www.intl-pag.org/17/abstracts/

Technical Abstract: Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a class of fatal neurodegenerative disorders that occur in humans, ruminants, cats, and mink. Three distinct TSEs afflict cattle: classical bovine spongiform encephalopathy (BSE), atypical H-type BSE, and atypical L-type BSE. Classical BSE was identified in the 1980s and is acquired by cattle through the consumption of feed contaminated with the infectious prion agent. Atypical BSEs have only recently been recognized as distinct cattle prion diseases and are extremely rare. The full extent of genetic susceptibilities to atypical BSEs is unknown; however, one atypical H-type case identified in the United States (2006) was most likely caused by a genetic mutation in the prion gene, E211K. We have identified an association of a bovine prion DNA haplotype with atypical BSE that is independent of E211K. The haplotype spans a portion of the prion gene that includes part of intron 2, the entire coding region of exon 3, and part of the three prime untranslated region of exon 3 (13 kb). Despite the low frequency of this haplotype among general cattle populations, it was present in a majority of H- and L-type atypical BSE cases from Canada, France, and the United States. This result indicates that there is a genetic component to atypical BSE susceptibility in addition to E211K.

http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=234699

I ask Professor Kong ;

Thursday, December 04, 2008 3:37 PM Subject: RE: re--Chronic Wating Disease (CWD) and Bovine Spongiform Encephalopathies (BSE): Public Health Risk Assessment

''IS the h-BSE more virulent than typical BSE as well, or the same as cBSE, or less virulent than cBSE? just curious.....''

Professor Kong reply ;

.....snip

''As to the H-BSE, we do not have sufficient data to say one way or another, but we have found that H-BSE can infect humans. I hope we could publish these data once the study is complete. Thanks for your interest.''

Best regards, Qingzhong Kong, PhD Associate Professor Department of Pathology Case Western Reserve University Cleveland, OH 44106 USA

END...TSS

I look forward to further transmission studies, and a true ENHANCED BSE/atypical BSE surveillance program put forth testing all cattle for human and animal consumption for 5 years. a surveillance program that uses the most sensitive TSE testing, and has the personnel that knows how to use them, and can be trusted. I look forward to a stringent mad cow feed ban being put forth, and then strictly enforced. we need a forced, not voluntary feed ban, an enhanced feed ban at that, especially excluding blood. we need some sort of animal traceability. no more excuses about privacy. if somebody is putting out a product that is killing folks and or has the potential to kill you, then everybody needs to know who they are, and where that product came from. same with hospitals, i think medical incidents in all states should be recorded, and made public, when it comes to something like a potential accidental transmission exposure event. so if someone is out there looking at a place to go have surgery done, if you have several hospitals having these type 'accidental exposure events', than you can go some place else. it only makes sense. somewhere along the road, the consumer lost control, and just had to take whatever they were given, and then charged these astronomical prices. some where along the line the consumer just lost interest, especially on a long incubating disease such as mad cow disease i.e. Transmissible Spongiform Encephalopathy. like i said before, there is much more to the mad cow story than bovines and eating a hamburger, we must start focusing on all TSE in all species. ...TSS

Month Number of Tests

Feb 2009 -- 1,891

Jan 2009 -- 4,620

http://www.aphis.usda.gov/newsroom/hot_issues/bse/surveillance/ongoing_surv_results.shtml

P02.35

Molecular Features of the Protease-resistant Prion Protein (PrPres) in H-type BSE

Biacabe, A-G1; Jacobs, JG2; Gavier-Widén, D3; Vulin, J1; Langeveld, JPM2; Baron, TGM1 1AFSSA, France; 2CIDC-Lelystad, Netherlands; 3SVA, Sweden

Western blot analyses of PrPres accumulating in the brain of BSE-infected cattle have demonstrated 3 different molecular phenotypes regarding to the apparent molecular masses and glycoform ratios of PrPres bands. We initially described isolates (H-type BSE) essentially characterized by higher PrPres molecular mass and decreased levels of the diglycosylated PrPres band, in contrast to the classical type of BSE. This type is also distinct from another BSE phenotype named L-type BSE, or also BASE (for Bovine Amyloid Spongiform Encephalopathy), mainly characterized by a low representation of the diglycosylated PrPres band as well as a lower PrPres molecular mass. Retrospective molecular studies in France of all available BSE cases older than 8 years old and of part of the other cases identified since the beginning of the exhaustive surveillance of the disease in 20001 allowed to identify 7 H-type BSE cases, among 594 BSE cases that could be classified as classical, L- or H-type BSE. By Western blot analysis of H-type PrPres, we described a remarkable specific feature with antibodies raised against the C-terminal region of PrP that demonstrated the existence of a more C-terminal cleaved form of PrPres (named PrPres#2 ), in addition to the usual PrPres form (PrPres #1). In the unglycosylated form, PrPres #2 migrates at about 14 kDa, compared to 20 kDa for PrPres #1. The proportion of the PrPres#2 in cattle seems to by higher compared to the PrPres#1. Furthermore another PK-resistant fragment at about 7 kDa was detected by some more N-terminal antibodies and presumed to be the result of cleavages of both N- and C-terminal parts of PrP. These singular features were maintained after transmission of the disease to C57Bl/6 mice. The identification of these two additional PrPres fragments (PrPres #2 and 7kDa band) reminds features reported respectively in sporadic Creutzfeldt-Jakob disease and in Gerstmann-Sträussler-Scheinker (GSS) syndrome in humans.

http://www.neuroprion.com/pdf_docs/conferences/prion2007/abstract_book.pdf

Research Project: Study of Atypical Bse Location: Virus and Prion Diseases of Livestock

Project Number: 3625-32000-086-05 Project Type: Specific Cooperative Agreement

Start Date: Sep 15, 2004 End Date: Sep 14, 2009

Objective: The objective of this cooperative research project with Dr. Maria Caramelli from the Italian BSE Reference Laboratory in Turin, Italy, is to conduct comparative studies with the U.S. bovine spongiform encephalopathy (BSE) isolate and the atypical BSE isolates identified in Italy. The studies will cover the following areas: 1. Evaluation of present diagnostics tools used in the U.S. for the detection of atypical BSE cases. 2. Molecular comparison of the U.S. BSE isolate and other typical BSE isolates with atypical BSE cases. 3. Studies on transmissibility and tissue distribution of atypical BSE isolates in cattle and other species.

Approach: This project will be done as a Specific Cooperative Agreement with the Italian BSE Reference Laboratory, Istituto Zooprofilattico Sperimentale del Piemonte, in Turin, Italy. It is essential for the U.S. BSE surveillance program to analyze the effectiveness of the U.S diagnostic tools for detection of atypical cases of BSE. Molecular comparisons of the U.S. BSE isolate with atypical BSE isolates will provide further characterization of the U.S. BSE isolate. Transmission studies are already underway using brain homogenates from atypical BSE cases into mice, cattle and sheep. It will be critical to see whether the atypical BSE isolates behave similarly to typical BSE isolates in terms of transmissibility and disease pathogenesis. If transmission occurs, tissue distribution comparisons will be made between cattle infected with the atypical BSE isolate and the U.S. BSE isolate. Differences in tissue distribution could require new regulations regarding specific risk material (SRM) removal.

http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=408490

Wednesday, February 11, 2009

Atypical BSE North America Update February 2009

Both of the BSE cases ascertained in the US native-born cattle were atypical cases (H-type), which contributed to the initial ambiguity of the diagnosis. 174, 185 In Canada, there have been 2 atypical BSE cases in addition to the 14 cases of the classic UK strain of BSE2: one was the H-type, and the other was of the L-type.198

snip...end

source :

Enhanced Abstract Journal of the American Veterinary Medical Association January 1, 2009, Vol. 234, No. 1, Pages 59-72

Bovine spongiform encephalopathy

Jane L. Harman, DVM, PhD; Christopher J. Silva, PhD

http://avmajournals.avma.org/doi/ref/10.2460/javma.234.1.59

Atypical BSE North America Update February 2009

http://bse-atypical.blogspot.com/2009/02/atypical-bse-north-america-update.html

Thursday, April 9, 2009

Docket No. FDA2002N0031 (formerly Docket No. 2002N0273) RIN 0910AF46 Substances Prohibited From Use in Animal Food or Feed; Final Rule: Proposed

http://madcowfeed.blogspot.com/2009/04/docket-no-fda2002n0031-formerly-docket.html

full text ;

Sunday, April 12, 2009 TRANSMISSION OF ATYPICAL BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN HUMANIZED MOUSE MODELS

http://bse-atypical.blogspot.com/2009/04/transmission-of-atypical-bovine.html

Thursday, March 19, 2009

MILLIONS AND MILLIONS OF POUNDS OF MAD COW FEED IN COMMERCE USA

http://madcowfeed.blogspot.com/2009/03/millions-and-millions-of-pounds-of-mad.html

Thursday, March 19, 2009

Chronic Wasting Disease Prions in Elk Antler Velvet (Nutritional Supplements and CJD)

http://chronic-wasting-disease.blogspot.com/2009/03/chronic-wasting-disease-prions-in-elk.html

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518