Tuesday, August 22, 2017

KOREA Infected US Mad Cow beef could have been on sale

US accused of not sharing enough data

By Park Jae-hyuk

The meat of a cow infected with mad cow disease, or bovine spongiform encephalopathy (BSE), could have been sold here, as the U.S. health authorities did not notice the outbreak of the disease before the cow's death in Alabama last month, according to a legal expert here, Tuesday.

Song Ki-ho of the Lawyers for a Democratic Society disclosed a letter purportedly sent to the government from the U.S. Embassy in Korea. The letter was written under the name of the agricultural affairs official and included additional information on the contaminated cow.

According to the lawyer, the letter reads that the cow died on the night of July 5, before it was transported to a slaughterhouse, and that an official from the Veterinary Services in Alabama took a tissue sample afterwards.

"This means that the U.S. government officials did not know the cow was contaminated before its death," Song said. "If the cow had been sent to a slaughterhouse before it died, its meat would have been on the market. Unless the U.S. government carries out overall inspections on cows there, the country's monitoring of mad cow disease won't be trustworthy."

The page-long letter explained how the U.S. health authorities detected the infection between July 6 and 13.

However, it still did not have the results of an epidemiologic survey, including the cow's age estimation, details on the farm and information on other cows raised there.

Seoul and Washington agreed that the latter immediately launch an epidemiologic investigation and notify the results in case of additional BSE outbreaks in the United States.

Song claimed the U.S. government is breaking its promise to the Korean government.

Diseases & welfare 

Infected US beef could have been on sale 

Posted : 2017-08-22 17:07Updated : 2017-08-22 19:42 

"The Korean health authorities should stop importing U.S. beef, until the epidemiologic survey results come out," he said. "Also, the requirement for the U.S. beef import should be as strict as that of China, which prohibits the importing of untraceable U.S. beef." 

 Hopes for FTA renegotiation

In addition to the controversy, livestock farmers in the two countries have lobbied each of their governments which began talks Tuesday over possible revisions to their bilateral Korea-U.S. free trade agreement (KORUS FTA).

The Hanwoo Association in Korea has urged the agriculture ministry to make it easier to take measures to safeguard against U.S. beef and delay the plan to eliminate tariffs on the product. Hanwoo refers to Korean beef. The Korean farmers also want stricter requirements for U.S. beef imports, including a ban in the case of a BSE outbreak.

They said the Korean government should take measures to increase the consumption of Korean beef.

The U.S. farmers, on the other hand, opposed the renegotiation of the KORUS FTA.

National Cattlemen's Beef Association and U.S. Meat Export Federation sent a letter last month to a U.S. agriculture minister, demanding it stop the procedures to revise the agreement.

They are known to have raked in huge profits from Korean consumers since the deal.

The share of U.S. beef in the Korean market has continued to grow, surpassing that of the Australian beef, according to the agriculture ministry here.


''US accused of not sharing enough data''

this was an understatement of mass proportions. this is what USDA inc and the OIE do. it's all about money, a few more body bags will not matter. in reality, the USDA OIE et al are guilty of poisoning the public around the world with the BSE MRR policy, a legal tool used to trade TSE prion disease around the globe, legally. this was done knowingly, with will, and with severe negligence, criminal negligence, but i would stop short of with malice, for now. but USDA inc and OIE are walking a fine line now towards that legality, imo. you can only ignore science for so long with junk science, blame it on ignorance for just so long, then it becomes criminal. that's my ruling anyway. ...Terry S. Singeltary Sr.


THURSDAY, AUGUST 17, 2017 

JAVMA NEWS Atypical BSE found in Alabama cow September 01, 2017


2017

TUESDAY, JULY 18, 2017 

USDA announces Alabama case of Bovine Spongiform Encephalopathy Alabama



THURSDAY, JULY 20, 2017 

USDA OIE Alabama Atypical L-type BASE Bovine Spongiform Encephalopathy BSE animal feeds for ruminants rule, 21 CFR 589.200



SUNDAY, JULY 23, 2017

atypical L-type BASE Bovine Amyloidotic Spongiform Encephalopathy BSE TSE PRION



SUNDAY, JULY 23, 2017

Experimental Infection of Cattle With a Novel Prion Derived From Atypical H-Type Bovine Spongiform Encephalopathy



MONDAY, AUGUST 21, 2017 

Similarities of Variant Creutzfeldt-Jakob Disease Strain in Mother and Son in Spain to UK Reference Case



MONDAY, AUGUST 21, 2017

Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion



WEDNESDAY, APRIL 05, 2017

Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease



MONDAY, AUGUST 14, 2017 

Experimental transmission of the chronic wasting disease agent to swine after oral or intracranial inoculation




TUESDAY, APRIL 18, 2017 

*** EXTREME USA FDA PART 589 TSE PRION FEED LOOP HOLE STILL EXIST, AND PRICE OF POKER GOES UP ***



TUESDAY, MARCH 28, 2017 

*** Passage of scrapie to deer results in a new phenotype upon return passage to sheep ***



SPONTANEOUS ATYPICAL BOVINE SPONGIFORM ENCEPHALOPATHY

***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***



MONDAY, JULY 17, 2017 

National Scrapie Eradication Program May 2017 Monthly Report Fiscal Year 2017



TUESDAY, JULY 18, 2017 

MINK FARMING USA TRANSMISSIBLE MINK ENCEPHALOPATHY TSE PRION DISEASE SURVEILLANCE AND TESTING




TUESDAY, AUGUST 8, 2017 

Concurrence With OIE Risk Designations for Bovine Spongiform Encephalopathy [Docket No. APHIS-2016-0092]



WEDNESDAY, JULY 26, 2017 

APHIS USDA Emerging Animal Disease Preparedness and Response Plan July 2017


 
2001 FDA CJD TSE Prion Singeltary Submission 

*** U.S.A. 50 STATE BSE MAD COW CONFERENCE CALL Jan. 9, 2001 

THURSDAY, AUGUST 17, 2017 

*** Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States revisited 2017 ***



FRIDAY, AUGUST 11, 2017 

*** Infectivity in bone marrow from sporadic CJD patients ***

Bioassays in transgenic mice expressing the human prion protein revealed the presence of unexpectedly high levels of infectivity in the bone marrow from seven out of eight sCJD cases. These findings may explain the presence of blood-borne infectivity in sCJD patients. They also suggest that the distribution of prion infectivity in peripheral tissues in sCJD patients could be wider than currently believed, with potential implications for the iatrogenic transmission risk of this disease. 

 

SATURDAY, JULY 15, 2017 

National Prion Center could lose all funding just as concern about CWD jumping to humans rises



 THURSDAY, JULY 13, 2017 

TEXAS CREUTZFELDT JAKOB DISEASE CJD TSE PRION



THURSDAY, JUNE 22, 2017 

National Prion Disease Pathology Surveillance Center Cases Examined(1) (May 18, 2017)



According to the Ohio-based CJD Foundation, CJD strikes roughly one out of a million people.

“But that number is deceptive,” said CJD Foundation President Florence Kranitz, “because CJD is often underreported and underdiagnosed, and it doesn’t affect infants, children or young adults — so for adults over 55, we think the number is closer to one in 9,000.” 





TUESDAY, AUGUST 1, 2017 

BSE INQUIRY DFA 17 Medicines and medical devices



TUESDAY, AUGUST 1, 2017 

Could Insulin be contaminated with and potentially spread, Transmissible Spongiform Encephalopathy TSE Prion, what if?



DFA 18 


DFA 16

MID 1995 TO THE FINAL DAYS farmers with BSE, teenagers with cjd,



Tracking spongiform encephalopathies in North America

Xavier Bosch

Published: August 2003


Summary;

“My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem.”

49-year-old Singeltary is one of a number of people who have remained largely unsatisfied after being told that a close relative died from a rapidly progressive dementia compatible with spontaneous Creutzfeldt-Jakob disease (CJD). So he decided to gather hundreds of documents on transmissible spongiform encephalopathies (TSE) and realised that if Britons could get variant CJD from bovine spongiform encephalopathy (BSE), Americans might get a similar disorder from chronic wasting disease (CWD) the relative of mad cow disease seen among deer and elk in the USA. Although his feverish search did not lead him to the smoking gun linking CWD to a similar disease in North American people, it did uncover a largely disappointing situation.

Singeltary was greatly demoralised at the few attempts to monitor the occurrence of CJD and CWD in the USA. Only a few states have made CJD reportable. Human and animal TSEs should be reportable nationwide and internationally, he complained in a letter to the Journal of the American Medical Association (JAMA 2003; 285: 733). "I hope that the CDC does not continue to expect us to still believe that the 85% plus of all CJD cases which are sporadic are all spontaneous, without route or source."

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

Singeltary, Sr et al. JAMA.2001; 285: 733-734. Vol. 285 No. 6, February 14, 2001 JAMA

Diagnosis and Reporting of Creutzfeldt-Jakob Disease

To the Editor: In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical cases. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationwide and internationally.

Terry S. Singeltary, Sr Bacliff, Tex

1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323.


Until recently, CWD was thought to be confined to the wild in a small region in Colorado. But since early 2002, it has been reported in other areas, including Wisconsin, South Dakota, and the Canadian province of Saskatchewan. Indeed, the occurrence of CWD in states that were not endemic previously increased concern about a widespread outbreak and possible transmission to people and cattle.

To date, experimental studies have proven that the CWD agent can be transmitted to cattle by intracerebral inoculation and that it can cross the mucous membranes of the digestive tract to initiate infection in lymphoid tissue before invasion of the central nervous system. Yet the plausibility of CWD spreading to people has remained elusive.

Part of the problem seems to stem from the US surveillance system. CJD is only reported in those areas known to be endemic foci of CWD. Moreover, US authorities have been criticised for not having performed enough prionic tests in farm deer and elk.

Although in November last year the US Food and Drug Administration issued a directive to state public-health and agriculture officials prohibiting material from CWD-positive animals from being used as an ingredient in feed for any animal species, epidemiological control and research in the USA has been quite different from the situation in the UK and Europe regarding BSE.

"Getting data on TSEs in the USA from the government is like pulling teeth", Singeltary argues. "You get it when they want you to have it, and only what they want you to have."

Norman Foster, director of the Cognitive Disorders Clinic at the University of Michigan (Ann Arbor, MI, USA), says that "current surveillance of prion disease in people in the USA is inadequate to detect whether CWD is occurring in human beings"; adding that, "the cases that we know about are reassuring, because they do not suggest the appearance of a new variant of CJD in the USA or atypical features in patients that might be exposed to CWD. However, until we establish a system that identifies and analyses a high proportion of suspected prion disease cases we will not know for sure". The USA should develop a system modelled on that established in the UK, he points out.

Ali Samii, a neurologist at Seattle VA Medical Center who recently reported the cases of three hunters "two of whom were friends" who died from pathologically confirmed CJD, says that "at present there are insufficient data to claim transmission of CWD into humans"; adding that "[only] by asking [the questions of venison consumption and deer/elk hunting] in every case can we collect suspect cases and look into the plausibility of transmission further". Samii argues that by making both doctors and hunters more aware of the possibility of prions spreading through eating venison, doctors treating hunters with dementia can consider a possible prion disease, and doctors treating CJD patients will know to ask whether they ate venison.

CDC spokesman Ermias Belay says that the CDC "will not be investigating the [Samii] cases because there is no evidence that the men ate CWD-infected meat". He notes that although "the likelihood of CWD jumping the species barrier to infect humans cannot be ruled out 100%" and that "[we] cannot be 100% sure that CWD does not exist in humans& the data seeking evidence of CWD transmission to humans have been very limited". 




26 March 2003 

Terry S. Singeltary, retired (medically) CJD WATCH 

I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to comment on the CDC's attempts to monitor the occurrence of emerging forms of CJD. Asante, Collinge et al [1] have reported that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest sporadic CJD. However, CJD and all human TSEs are not reportable nationally. CJD and all human TSEs must be made reportable in every state and internationally. I hope that the CDC does not continue to expect us to still believe that the 85%+ of all CJD cases which are sporadic are all spontaneous, without route/source. We have many TSEs in the USA in both animal and man. CWD in deer/elk is spreading rapidly and CWD does transmit to mink, ferret, cattle, and squirrel monkey by intracerebral inoculation. With the known incubation periods in other TSEs, oral transmission studies of CWD may take much longer. Every victim/family of CJD/TSEs should be asked about route and source of this agent. To prolong this will only spread the agent and needlessly expose others. In light of the findings of Asante and Collinge et al, there should be drastic measures to safeguard the medical and surgical arena from sporadic CJDs and all human TSEs. I only ponder how many sporadic CJDs in the USA are type 2 PrPSc? 



2 January 2000 British Medical Journal U.S. 

Scientist should be concerned with a CJD epidemic in the U.S., as well 



15 November 1999 British Medical Journal hvCJD in the USA * BSE in U.S. 





FRIDAY, JULY 28, 2017 

Korean government should suspend the import of U.S. beef by amending terms of trade




kind regards, terry

Friday, July 28, 2017

Korean government should suspend the import of U.S. beef by amending terms of trade


Subject: Re-Korea urged to stop US beef imports

Greetings Professor Woo Hee-jong, Seoul National University College of Veterinary Science, and the Honorable People of Korea, 

i wish to kindly comment on the following statement from Professor Woo Hee-jong about the follow statements in this article please;


Diseases & welfare 

Korea urged to stop US beef imports 

Posted : 2017-07-28 12:36 Updated : 2017-07-28 18:29 

 By Park Jae-hyuk

The Korean government should suspend the import of U.S. beef by amending terms of trade, a group of experts said Wednesday.

Amid growing concern on the safety of U.S. beef after an outbreak of mad cow disease, or bovine spongiform encephalopathy (BSE), in Alabama, the experts refuted the government's argument, presenting scientific evidence at a press conference in Seoul.

"The Korean government groundlessly claims, without any epidemiological survey by the U.S. government, that an atypical case of BSE is not dangerous to humans," said Prof. Woo Hee-jong of the Seoul National University College of Veterinary Science. "The terms of trade are unfair as well."

The professor urged the Moon Jae-in administration to confidently request a renegotiation of the deal with the U.S. government if it really respects the will of the candlelit protestors who played a big role in ousting the scandal-laden former President Park Geun-hye.

"An atypical case of BSE may be more dangerous to people, as it also contaminates a cow's lean meat, not only its brain or spinal cord," said Woo Seoc-kyun, vice representative of the Center for Health and Social Change.

"Under the U.S. inspection system, the infected 11-year-old cow might have been sold to consumers, if it had not died before slaughter."

He also noted that although Taiwan added more parts of beef to its list of import bans without any agreement with the U.S. government, it did not face any challenges through the World Trade Organization.

Veterinarian Hong Ha-il said the U.S. government still allows farmers to feed cows with feed containing parts of animals if the feed does not contain specified risk materials (SRM).

Hong also doubted the U.S. government's arguments about the infected cow's age.

"The U.S. government merely estimated its age with abrasion loss of the cow's teeth," he said. "I think it wants to emphasize the cow was born before 2008, when the U.S. government began to ban animal feed made with SRM."

The veterinarian said Washington, not Seoul, should prove the safety of its cows.

Although Song Ki-ho of the Lawyers for a Democratic Society admitted that other countries have yet to prohibit U.S. beef after the latest outbreak of BSE, the experts emphasized that most of those countries are exporters of their beef, unlike Korea.

"BSE occurred in Japan, Canada and Europe as well. Such countries may find it difficult to carry out import bans on U.S. beef," said Cho Neung-hee, a director for MBC's PD Notebook, who spotlighted the issue in 2008.

"Such countries as Australia, Taiwan and China confidently exercised their rights to suspend the import of suspicious U.S. beef during previous BSE outbreaks."


Website opens on mad cow disease after Moon's order The Ministry of Agriculture, Food and Rural Affairs has established a special website on mad cow disease, following President Moon Jae-in’s order to give people details about it. T...


Greetings Professor Woo Hee-jong, Seoul National University College of Veterinary Science, and the Honorable People of Korea, 


i wish to kindly comment on the following statement from Professor Woo Hee-jong ;


"The Korean government groundlessly claims, without any epidemiological survey by the U.S. government, that an atypical case of BSE is not dangerous to humans," said Prof. Woo Hee-jong of the Seoul National University College of Veterinary Science. "The terms of trade are unfair as well."

"An atypical case of BSE may be more dangerous to people, as it also contaminates a cow's lean meat, not only its brain or spinal cord," said Woo Seoc-kyun, vice representative of the Center for Health and Social Change.

"Under the U.S. inspection system, the infected 11-year-old cow might have been sold to consumers, if it had not died before slaughter."

He also noted that although Taiwan added more parts of beef to its list of import bans without any agreement with the U.S. government, it did not face any challenges through the World Trade Organization.

Veterinarian Hong Ha-il said the U.S. government still allows farmers to feed cows with feed containing parts of animals if the feed does not contain specified risk materials (SRM).

Hong also doubted the U.S. government's arguments about the infected cow's age.

"The U.S. government merely estimated its age with abrasion loss of the cow's teeth," he said. "I think it wants to emphasize the cow was born before 2008, when the U.S. government began to ban animal feed made with SRM."

The veterinarian said Washington, not Seoul, should prove the safety of its cows.

snip...end


YES SIR! 

OUTSTANDING DEDUCTION SIR! 

everything you stated is the truth, and science shows this.

I have documented it all for you below.

plus, see the HISTORY at the bottom of a letter sent to me back in 2007 from Korea, asking me to come and speak about this very important on TSE Prion disease;

Date: Jan 26, 2007 

Dear Terry S. Singeltary Sr. 

My name in Seoungwon Lee and I work for National Assemblywoman (MP) Sang-Jeong Sim, in South Korea. Below is a message from Mr. Kwon. Please get back to us regarding the letter. Thank you. Seoungwon Lee Legislative Assistant National Assembly Republic of Korea

Dear Terry S. Singeltary Sr....snip...end...see history at bottom.

2017

TUESDAY, JULY 18, 2017 

USDA announces Alabama case of Bovine Spongiform Encephalopathy Alabama


THURSDAY, JULY 20, 2017 

USDA OIE Alabama Atypical L-type BASE Bovine Spongiform Encephalopathy BSE animal feeds for ruminants rule, 21 CFR 589.200


SUNDAY, JULY 23, 2017

atypical L-type BASE Bovine Amyloidotic Spongiform Encephalopathy BSE TSE PRION


SUNDAY, JULY 23, 2017

Experimental Infection of Cattle With a Novel Prion Derived From Atypical H-Type Bovine Spongiform Encephalopathy


Needless Conflict...


Saturday, July 23, 2016

BOVINE SPONGIFORM ENCEPHALOPATHY BSE TSE PRION SURVEILLANCE, TESTING, AND SRM REMOVAL UNITED STATE OF AMERICA UPDATE JULY 2016


Tuesday, July 26, 2016

Atypical Bovine Spongiform Encephalopathy BSE TSE Prion UPDATE JULY 2016


Monday, June 20, 2016

Specified Risk Materials SRMs BSE TSE Prion Program



***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***
 


MONDAY, JULY 17, 2017 

National Scrapie Eradication Program May 2017 Monthly Report Fiscal Year 2017


TUESDAY, JULY 18, 2017 

MINK FARMING USA TRANSMISSIBLE MINK ENCEPHALOPATHY TSE PRION DISEASE SURVEILLANCE AND TESTING



IN the USA, the failed ruminant mad cow feed ban is even much worse then the UK and EU. 

Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

Location: Virus and Prion Research

Title: Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease

Author item Moore, Sarah item Kunkle, Robert item Kondru, Naveen item Manne, Sireesha item Smith, Jodi item Kanthasamy, Anumantha item West Greenlee, M item Greenlee, Justin

Submitted to: Prion Publication Type: Abstract Only Publication Acceptance Date: 3/15/2017 Publication Date: N/A Citation: N/A Interpretive Summary:

Technical Abstract: Aims: Chronic wasting disease (CWD) is a naturally-occurring, fatal neurodegenerative disease of cervids. We previously demonstrated that disease-associated prion protein (PrPSc) can be detected in the brain and retina from pigs challenged intracranially or orally with the CWD agent. In that study, neurological signs consistent with prion disease were observed only in one pig: an intracranially challenged pig that was euthanized at 64 months post-challenge. The purpose of this study was to use an antigen-capture immunoassay (EIA) and real-time quaking-induced conversion (QuIC) to determine whether PrPSc is present in lymphoid tissues from pigs challenged with the CWD agent.

Methods: At two months of age, crossbred pigs were challenged by the intracranial route (n=20), oral route (n=19), or were left unchallenged (n=9). At approximately 6 months of age, the time at which commercial pigs reach market weight, half of the pigs in each group were culled (<6 challenge="" groups="" month="" pigs="" remaining="" the="">6 month challenge groups) were allowed to incubate for up to 73 months post challenge (mpc). The retropharyngeal lymph node (RPLN) was screened for the presence of PrPSc by EIA and immunohistochemistry (IHC). The RPLN, palatine tonsil, and mesenteric lymph node (MLN) from 6-7 pigs per challenge group were also tested using EIA and QuIC.

Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 5="" 6="" at="" by="" detected="" eia.="" examined="" group="" in="" intracranial="" least="" lymphoid="" month="" months="" of="" one="" pigs="" positive="" prpsc="" quic="" the="" tissues="" was="">6 months group, 5/6 pigs in the oral <6 4="" and="" group="" months="" oral="">6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%). Conclusions:

This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge.

CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease.

Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains.


CONFIDENTIAL

EXPERIMENTAL PORCINE SPONGIFORM ENCEPHALOPATHY

While this clearly is a cause for concern we should not jump to the conclusion that this means that pigs will necessarily be infected by bone and meat meal fed by the oral route as is the case with cattle. ...


we cannot rule out the possibility that unrecognised subclinical spongiform encephalopathy could be present in British pigs though there is no evidence for this: only with parenteral/implantable pharmaceuticals/devices is the theoretical risk to humans of sufficient concern to consider any action.


 Our records show that while some use is made of porcine materials in medicinal products, the only products which would appear to be in a hypothetically ''higher risk'' area are the adrenocorticotrophic hormone for which the source material comes from outside the United Kingdom, namely America China Sweden France and Germany. The products are manufactured by Ferring and Armour. A further product, ''Zenoderm Corium implant'' manufactured by Ethicon, makes use of porcine skin - which is not considered to be a ''high risk'' tissue, but one of its uses is described in the data sheet as ''in dural replacement''. This product is sourced from the United Kingdom.....


 snip...see much more here ;

WEDNESDAY, APRIL 05, 2017

Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease


WEDNESDAY, APRIL 05, 2017

*** Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease ***


THURSDAY, JULY 13, 2017 

*** EFSA BSE Sixty cases of mad cow disease since 2001 breached feed ban likely the cause 

Scientists investigate origin of isolated BSE cases


Discussion: The C, L and H type BSE cases in Canada exhibit molecular characteristics similar to those described for classical and atypical BSE cases from Europe and Japan. 

*** This supports the theory that the importation of BSE contaminated feedstuff is the source of C-type BSE in Canada.

*** It also suggests a similar cause or source for atypical BSE in these countries. ***

P.9.21

Molecular characterization of BSE in Canada

Jianmin Yang 1 , Sandor Dudas 2 , Catherine Graham 2 , Markus Czub 3 , Tim McAllister 1 , Stefanie Czub 1 1 Agriculture and Agri-Food Canada Research Centre, Canada; 2 National and OIE BSE Reference Laboratory, Canada; 3 University of Calgary, Canada

Background: Three BSE types (classical and two atypical) have been identified on the basis of molecular characteristics of the misfolded protein associated with the disease. To date, each of these three types have been detected in Canadian cattle. Objectives: This study was conducted to further characterize the 16 Canadian BSE cases based on the biochemical properties of there associated PrPres.

Methods: Immuno-reactivity, molecular weight, glycoform profiles and relative proteinase K sensitivity of the PrPres from each of the 16 confirmed Canadian BSE cases was determined using modified Western blot analysis.

Results: Fourteen of the 16 Canadian BSE cases were C type, 1 was H type and 1 was L type. The Canadian H and L-type BSE cases exhibited size shifts and changes in glycosylation similar to other atypical BSE cases. PK digestion under mild and stringent conditions revealed a reduced protease resistance of the atypical cases compared to the C-type cases. N terminal-specific antibodies bound to PrPres from H type but not from C or L type. The C-terminal-specific antibodies resulted in a shift in the glycoform profile and detected a fourth band in the Canadian H-type BSE.

Discussion: The C, L and H type BSE cases in Canada exhibit molecular characteristics similar to those described for classical and atypical BSE cases from Europe and Japan. This supports the theory that the importation of BSE contaminated feedstuff is the source of C-type BSE in Canada. It also suggests a similar cause or source for atypical BSE in these countries.

see page 176 of 201 pages...tss


*** Singeltary reply ; Molecular, Biochemical and Genetic Characteristics of BSE in Canada Singeltary reply;


***however in 1 C-type challenged animal, Prion 2015 Poster Abstracts S67 PrPsc was not detected using rapid tests for BSE.

***Subsequent testing resulted in the detection of pathologic lesion in unusual brain location and PrPsc detection by PMCA only.

*** IBNC Tauopathy or TSE Prion disease, it appears, no one is sure ***

Posted by Terry S. Singeltary Sr. on 03 Jul 2015 at 16:53 GMT


*** PLEASE SEE THIS URGENT UPDATE ON CWD AND FEED ANIMAL PROTEIN ***

Sunday, March 20, 2016

Docket No. FDA-2003-D-0432 (formerly 03D-0186) Use of Material from Deer and Elk in Animal Feed ***UPDATED MARCH 2016*** Singeltary Submission


SEE MAD COW FEED VIOLATIONS AFER MAD COW FEED VIOLATIONS ;


Tuesday, April 19, 2016

Docket No. FDA-2013-N-0764 for Animal Feed Regulatory Program Standards Singeltary Comment Submission


TUESDAY, JANUARY 17, 2017 

FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEEDVIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE 2016 to 2017 BSE TSE PRION



Chronic wasting disease continues to spread Disease of cervids causing local population declines


PRION 2017 DECIPHERING NEURODEGENERATIVE DISORDERS 

 Subject: PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS VIDEO

PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS

PRION 2017 CONFERENCE VIDEO



Chronic Wasting Disease CWD TSE Prion to Humans, who makes that final call, when, or, has it already happened?

TUESDAY, JUNE 13, 2017

PRION 2017 CONFERENCE ABSTRACT First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress


TUESDAY, JULY 04, 2017

*** PRION 2017 CONFERENCE ABSTRACTS ON CHRONIC WASTING DISEASE CWD TSE PRION ***


TUESDAY, JUNE 13, 2017

PRION 2017 CONFERENCE ABSTRACT Chronic Wasting Disease in European moose is associated with PrPSc features different from North American CWD


URINE

SUNDAY, JULY 16, 2017

*** Temporal patterns of chronic wasting disease prion excretion in three cervid species ***


WEDNESDAY, JULY 26, 2017

Chronic wasting disease continues to spread Disease of cervids causing local population declines


WEDNESDAY, JULY 26, 2017 

APHIS USDA Emerging Animal Disease Preparedness and Response Plan July 2017


THURSDAY, JUNE 22, 2017 

World Organisation for Animal Health (OIE) to establish liaison office in College Station, Texas



THURSDAY, JULY 13, 2017 
 
TEXAS CREUTZFELDT JAKOB DISEASE CJD TSE PRION
 
 
National Prion Center could lose all funding just as concern about CWD jumping to humans rises
 
SATURDAY, JULY 15, 2017 
 
*** National Prion Center could lose all funding just as concern about CWD jumping to humans rises
 
 
SATURDAY, JULY 22, 2017 
 
Why the U.S. Needs to Continue Prion Disease Surveillance, instead of reducing funding to zero
 

*** U.S.A. 50 STATE BSE MAD COW CONFERENCE CALL Jan. 9, 2001 
 

2001 FDA CJD TSE Prion Singeltary Submission

HISTORY

USDA VS KOREA typical or atypical BSe

FRIDAY, MAY 9, 2008 

USDA VS KOREA typical or atypical BSe

Honorable people of Korea,

a kind and warm greetings from Texas.

i cannot sit here and allow my government to lie to the korean people. i have been following the issue of Transmissible Spongiform Encephalopathy for over a decade, since the death of my mother to the Heidenhain Variant of Creutzfeldt Jakob Disease, confirmed. i have followed this on a daily basis since 12-14-97. there is so much i want to tell you, that the USDA and the FDA are not telling you.

i almost got to see your beautiful country, but in the last minute, my trip was cancelled. i was asked to come speak a year or so ago ;

Name: Terry S. Singeltary Sr. 

Date: Jan 26, 2007 

Dear Terry S. Singeltary Sr. 

My name in Seoungwon Lee and I work for National Assemblywoman (MP) Sang-Jeong Sim, in South Korea. Below is a message from Mr. Kwon. Please get back to us regarding the letter. Thank you. Seoungwon Lee Legislative Assistant National Assembly Republic of Korea

Dear Terry S. Singeltary Sr.

Greetings from Korea.

I have learned about what you and your family have been through a internet. Being the father of a small family, I can only imagine the sense of loss that you and your family still must feel regarding your mother.

Through the internet, many people here in Korea have learnt about the story of your family and it has created a great deal of concern. Your experience had particular relevance for the citizens here, for the Korean government, in connection to the free trade agreement it is negotiating with the United States, is about to restart the sale of the unsafe American beef to the general public.

The Korean government has already imported the first load American beef and is currently going through the inspection period. There has been a great deal of controversy regarding the safety of these products, and a precipitous increase in public interest regarding the causes and symptoms of vCJD.

It is in this context that we are preparing a session together with National Assembly members and relevant NGOs to hear from those who have had direct experience with the human variant of BSE. We are very interested in hearing about the symptoms that your mother showed, your views on the response from the US government to the many deaths that resulted from this disease, the reaction from the general public, and any other area that you would wish to speak about. There would also be experts and academics in the area to speak at the session as well. We believe that it would greatly contribute to raising awareness about the issue, as well as help politicians and civic activists to consider the repercussions of the beef import issue.

We would like to request your help in this regard. We are planning for the session to be held in Seoul on the 23rd of this November. We would very much like to have you present in order to help prevent such tragic incidents from happening in Korea. We would, of course, pay for the trip and accommodations for the duration of your stay. If you were to participate, we could also meet with members from the agricultural committee of the National Assembly and from other related organizations to urge more interest to the issue.

Please do not hesitate to offer suggestions or ask us any questions that you might have. We look forward to a positive response and to meeting you in Seoul.

Thank you. Sincerely, Sim Sang-Jeong Head of the Democratic Labor Party Parliamentary Committee on the Korea-US FTA Member of the National Assembly Republic of Korea






kindest regards, 

Terry S. Singeltary Sr.
Bacliff, Texas USA 77518