S. Korea confirms first death caused by Creutzfeldt-Jakob disease
Publish By David K. Barger Updated 06/12/2012 8:41 pm in
Health&Lifestyle / no comments
SEOUL, Nov. 29 – The first death in South Korea caused by neurodegenerative
Creutzfeldt-Jakob disease was confirmed by health authorities on Tuesday.
The Center for Disorder Control (KCDC) announced that a 54-year- old woman
was diagnosed with iatrogenic Creutzfeldt-Jakob disease (iCJD) after she died in
July this year.
She is believed to have been infected during her brain surgery 23 years ago
when she had dead brain tissue replaced with a graft of a dura mater product
named Lyodura. The victim did not show symptoms until the occurrence of
paralysis in her face and toe in June last year.
The KCDC said the transplanted dura mater originated from the body of a CJD
patient. The center said it will track down potential patients who received
similar transplants with Lyoduras around 1987.
Some 400 cases of iCDJ have been reported in 20 countries, 200 of which
were caused after dura mater transplant operations. KCDC, meanwhile, stressed
that there is no correlation between this case and the Variant Creutzfeldt-Jakob
disease, which is often referred to as human mad cow disease.
> S. Korea confirms first death caused by Creutzfeldt-Jakob disease
???
CONFUCIUS CONFUSED AGAIN ?
Thursday, December 8, 2011
S. Korea confirms second case of iatrogenic Creutzfeldt-Jakob disease
48-year-old man 2011/12/08 11:08 KST
Wednesday, November 30, 2011
First iCJD Death Confirmed in Korea
Development of Policy and Strategy for the Control of Creutzfeldt-Jakob
Disease in Korea
Choi SI, Jeong BH, Kim YS.
Korean J Epidemiol
2005 Jun 27(1):81-89. Korean.
Total References:16 Cited Korean References:2 Times Cited:0
PURPOSE: Through the understanding of the current status of transmissible
spongiform encephalopathy(TSE), this study was conducted to contribute to the
development of policy and strategy for the control of TSE in Korea in order to
keep Korea as a bovine spongiform encephalopathy(BSE)- and variant
Creutzfeldt-Jakob disease(vCJD)-free country. BSE and vCJD cases have not been
found in Korea.
During 2001-2004, the number of patients who have been diagnosed as a
definite or probable CJD was 121, which are consisted of 62 male and 59
female(average age: 63 years old). The occurrence of the patients was 5-59
people per year until 2003 and has been gradually increasing due to the recent
increase in the diagnostic rate rather than the increase of the incidence.
In 2004, the annual occurrence of sporadic CJD(sCJD) in Korea was 1 people
per million, which is similar to the average occurrence rate of the world. Two
cases of chronic wasting disease(CWD) in deer were found in Chungcheongbuk-do,
one in August 2001 and one in October 2001. After that, 4 more CWD-affected deer
have been reported in Kyungsangnam-do area in November 2004.
We have also examined the possibility that Korean CJD occurred as a result
of dietary exposure to BSE. Fortunately, all of Korean CJD patients were not
vCJD cases. However, if BSE occurs in Korea, there is a great potential for most
of the Korean population to be easily infected with BSE due to their highly
susceptible genotype to BSE infection as well as their traditional food habit.
In 2003, the total number of people who left Korea was almost identical with the
total number of people who entered Korea. However, we could not analyze the
number of people who visited or stayed in the UK and Europe during 1980s~1990s,
in which BSE was prevalent in Europe, because there was no statistical data
available.
Affiliation:
Ilsong Institute of Life Science, Hallym University, Anyang.
yskim@hallym.ac.kr Department of Microbiology, Hallym University College of
Medicine, Chunchon.
J Korean Med Sci. 2010 July; 25(7): 1097–1100.
Published online 2010 June 16. doi: 10.3346/jkms.2010.25.7.1097
PMCID: PMC2890893 Familial Creutzfeldt-Jakob Disease with V180I Mutation
fCJD due to the V180I, as our patient's, is extremely rare, with all
reported cases have come from Japan with one from France (11, 12), and two in
the United states in a non-Asian (Geschwind et al. unpublished results) (13). To
our knowledge this is the first reported case in South Korea.
Korean Med Sci. 1998 Jun;13(3):234-240. Published online 2009 June 22.
Copyright © 1998 The Korean Academy of Medical Sciences
Molecular analysis of prion protein gene (PRNP) in Korean patients with
Creutzfeldt-Jakob disease
B H Jeong, W K Ju, K Huh, E A Lee, I S Choi, J H Im, E K Choi and Y S Kim
Institute of Environment & Life Science and Department of Microbiology,
College of Medicine, Hallym University, Chunchon, Korea. This
Abstract
Creutzfeldt-Jakob disease (CJD), a relatively uncommon human dementia, is
caused by an unconventional slow infectious agent. Several cases of CJD,
clinically or histopathologically diagnosed, have been reported in Korea. In
order to confirm the diagnosis of CJD and also differential diagnosis of
sporadic and familial types of CJD in Korea, we studied two patients who had
symptoms of CJD. The histopathological and immunohistochemical studies showed
spongiform neurodegeneration and expression of abnormal isoform of prion protein
(PrPSc) in astrocytes. Thus, these two patients were diagnosed CJD. To
investigate whether these patients were sporadic or familial type of CJD, the
molecular analyses of the prion protein gene (PRNP) were done by restriction
fragment length polymorphism (RFLP) and DNA sequencing. In the cases of a
healthy Korean and two CJD patients, no point mutation was detected in the known
hot spots (178, 180, 200, 210, and 232) and they exhibited wild type PRNP
sequences. We concluded that both patients have a sporadic type of CJD, but not
familial type.
J Korean Med Sci. 1991 Sep;6(3):273-278. Published online 2009 May 26.
Copyright © 1991 The Korean Academy of Medical Sciences
A case of Creutzfeldt-Jakob disease
Jae Kwan Cha, Myung Ho Kim, Suck Jun Oh and Eun Kyung Hong Department of
Neurology, College of Medicine, Hanyang University, Seoul, Korea. Abstract
Creutzfeldt-Jakob disease (CJD) is presumably caused by a slow infectious
pathogen or prion. The principal clinical features of Creutzfeldt-Jakob disease
are dementia, pyramidal and extrapyramidal symptoms and signs, cerebellar
dysfunction, and myoclonus. The patient rapidly deteriorates, declines to a
vegetative state, becomes comatous, and is ultimately dead within several
months. The authors present a case of Creutzfeldt-Jakob disease, proved by
clinical findings, typical serial EEG, and pathologic features.
Keywords: Creutzfeldt-Jakob disease.
SEE OTHER iCJD cases recently ;
6 December 2012
HONG KONG CHP closely monitors a probable case of sporadic
Creutzfeldt-Jakob Disease
The Centre for Health Protection (CHP) of the Department of Health today
(December 6) received a report from the health authority of Macao concerning a
probable case of sporadic Creutzfeldt-Jakob Disease (CJD) affecting a
51-year-old female Macao resident who had undergone a brain operation in a
private hospital in Hong Kong.
According to the health authority of Macao, the woman who developed
progressive dementia with limbs spasm, unstable gait, muscle twitching and
visual disturbance suggestive of CJD, has been admitted to a hospital in Macao
on October 30. Her clinical diagnosis was sporadic CJD and the patient is now in
severe condition.
Investigation by the Macao health authority revealed that the woman had
received a brain surgery in a private hospital in Hong Kong on September 19.
Upon receipt of the report, the CHP acted in accordance with the
international practice and advised the hospital to contact the patients who had
undergone procedures using the same set of instruments as the patient since
September 19.
According to the current understanding, the transmission risk is extremely
low. The contact tracing is a precautionary measure.
A CHP spokesman said, "CJD is a rare disease that affects the brain and is
thought to be caused by the build-up of an abnormal, transmissible protein
called 'prion' in the brain."
The spokesman said surgical instruments used on the patient should have
been sterilised but may not be enough to eradicate the prions which are the
causing agents of the disease. Contact tracing conducted by the hospital is
under way.
The clinical feature of CJD is characterised by dementia and difficulties
in walking. Early symptoms include memory loss, unsteady gait and loss of
co-ordination of limbs. These dementia-like symptoms will worsen and twitching
of limbs and trunk will occur. Besides, visual disturbance, abnormal behaviour
and seizures can occur. Most patients die within one to two years after onset of
symptoms.
Since CJD is not transmitted through casual contact, isolation of patients
is not necessary. To prevent the disease from spreading, tissue or organ
transplant from any CJD patients or re-use of potentially contaminated surgical
instruments should be avoided.
Ends/Thursday, December 6, 2012
Scientific Committee on Emerging and Zoonotic Diseases
Epidemiology of Creutzfeldt-Jakob Disease in Hong Kong
Tuesday, July 31, 2012
11 patients may have been exposed to fatal disease Creutzfeldt-Jakob
Disease CJD Greenville Memorial Hospital
Thursday, August 02, 2012
CJD case in Saint John prompts letter to patients Canada
CJD case in Saint John prompts letter to patients
Friday, August 24, 2012
Iatrogenic prion diseases in humans: an update
Friday, November 23, 2012
sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA,
AND CANADA
Sunday, December 2, 2012
CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE
BLEW IT’
Thursday, December 06, 2012
Hong Kong CHP closely monitors a probable case of sporadic
Creutzfeldt-Jakob Disease
Sunday, June 17, 2012
MBC’s PD Notebook infamous mad cow program victorious in final lawsuits
South Korea
Why Americans, As Well as Koreans, Should Be Worried About Mad Cow Tainted
USA Beef
By Terry S. Singeltary Sr.
May 15, 2008
Straight to the Source
Tuesday, May 13, 2008
Concerned Americans against Mad Cow Disease STATEMENT OF SOLIDARITY with
Koreans May 13, 2008
Wednesday, February 10, 2010
The Honorable Ms. Kim Min-sun Anti-US Beef Actress Prevails in Court
Saturday, April 10, 2010
TOYOTA VS MAD COW DISEASE USA OIE BSE MRR IMPORT AND EXPORT TRADE WARS
Tuesday, November 08, 2011
Can Mortality Data Provide Reliable Indicators for Creutzfeldt-Jakob
Disease Surveillance? A Study in France from 2000 to 2008
Vol. 37, No. 3-4, 2011 Original Paper Conclusions:These findings raise
doubt about the possibility of a reliable CJD surveillance only based on
mortality data.
Terry S. Singeltary Sr. on the Creutzfeldt-Jakob Disease Public Health
Crisis
full text with source references ;
Friday, November 23, 2012
sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA,
AND CANADA
Saturday, October 6, 2012
TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM
ENCEPHALOPATHIES 2011 Annual Report
Tuesday, November 6, 2012
Transmission of New Bovine Prion to Mice, Atypical Scrapie, BSE, and
Sporadic CJD, November-December 2012 update
Sunday, December 2, 2012
CANADA 19 cases of mad cow disease SCENARIO 4: ‘WE HAD OUR CHANCE AND WE
BLEW IT’
TSS
